Influenza A/Philippines/2/82 outbreak in a nursing home: Limitations of influenza vaccination in the aged

Arroyo, Julio C.; Postic, Boško; Brown, Abraham M.; Harrison, K; Birgenheier, Robert; Dowda, H

doi:10.1016/0196-6553(84)90005-1

Cited by 37 publications

(8 citation statements)

References 15 publications

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“…Medical and neonatal ICUs, transplant units, chronic-care wards, and nursing homes are at increased risk for nosocomial outbreaks of influenza, which are characterized by abrupt onset and rapid spread [23][24][25][26].…”

Section: Epidemiology Of Influenza Diseasementioning

confidence: 99%

Influenza in the Intensive Care Unit

Oliveirã

Lee

Colice

2003

J Intensive Care Med

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Influenza remains an important epidemic viral infection. Thousands of deaths occur and billions of dollars are spent each year with influenza-related illnesses. Morbidity and mortality are largely attributed to respiratory complications that may require intensive care unit (ICU) admission. Medical and neonatal ICUs, transplant units, chronic-care wards, and nursing homes are at increased risk for nosocomial outbreaks of influenza, which are characterized by abrupt onset and rapid spread. In this article, the authors review the current concepts, recent advances, and management strategies in influenza-associated pneumonia. Pertinent issues to the critical care practitioner are discussed in detail.

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Section: Epidemiology Of Influenza Diseasementioning

confidence: 99%

Influenza in the Intensive Care Unit

Oliveirã

Lee

Colice

2003

J Intensive Care Med

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“…Outbreaks are usually due to influenza A, although outbreaks caused by influenza B may also occur (36,61,124). Influenza outbreaks frequently affect a high proportion of nursing home residents, as many as 50 to 100%; many staff members may also be ill (7,59,70,156). The case/fatality ratios are also high: 10 to 35% of ill residents (124).…”

Section: Outbreaks Of Infectionmentioning

confidence: 99%

Infections and antibiotic resistance in nursing homes

1996

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Infections occur frequently in nursing home residents. The most common infections are pneumonia, urinary tract infection, and skin and soft tissue infection. Aging-associated physiologic and pathologic changes, functional disability, institutionalization, and invasive devices all contribute to the high occurrence of infection. Antimicrobial agent use in nursing homes is intense and usually empiric. All of these factors contribute to the increasing frequency of antimicrobial agent-resistant organisms in nursing homes. Programs that will limit the emergence and impact of antimicrobial resistance and infections in nursing homes need to be developed.

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“…Most work evaluating influenza control measures has focused on vaccination and antivirals, reported direct vaccine effectiveness in a single LTCF after a seasonal outbreak, [5][6][7][8][9][10][11][12][13][14][15][16] or used a randomized controlled trial (RCT) design where individuals or facilities randomized to receive an intervention were compared with those receiving a placebo or the standard of care. [17][18][19][20][21] While these studies are essential to establishing the effectiveness of interventions, several gaps in our understanding of the effectiveness of control measures remain.…”

Section: Introductionmentioning

confidence: 99%

Influenza outbreak control practices and the effectiveness of interventions in long‐term care facilities: a systematic review

Rainwater-Lovett

Chun

Lessler

2013

Influenza Resp Viruses

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Summary Background Evaluation of influenza control measures frequently focuses on the efficacy of chemoprophylaxis and vaccination while the effectiveness of non-pharmaceutical interventions (NPI) receives less emphasis. While influenza control measures are frequently reported for individual outbreaks, there have been few efforts to characterize the real-world effectiveness of these interventions across outbreaks. Objectives To characterize influenza case and outbreak definitions and control measures reported by long-term care facilities (LTCFs) of elderly adults, and estimate the reduction in influenza-like illness (ILI) attack rates due to chemoprophylaxis and NPI. Methods We conducted a literature search in PubMed including English-language studies reporting influenza outbreaks among elderly individuals in LTCFs. A Bayesian hierarchical logistic regression model estimated the effects of control measures on ILI attack rates. Results Of 654 articles identified in the literature review, 37 articles describing 60 influenza outbreaks met the inclusion criteria. Individuals in facilities where chemoprophylaxis was used were significantly less likely to develop influenza A or B than those in facilities with no interventions (odds ratio [OR] 0.48, 95% CI: 0.28, 0.84). Considered by drug class, adamantanes significantly reduced infection risk (OR 0.22, 95% CI: 0.12, 0.42) while neuraminidase inhibitors did not show a significant effect. Although NPI showed no significant effect, the results suggest that personal protective equipment may produce modest protective effects. Conclusions Our results indicate pharmaceutical control measures have the clearest reported protective effect in LTCFs. Non-pharmaceutical approaches may be useful; however, most data were from observational studies and standardized reporting or well-conducted clinical trials of NPI are needed to more precisely measure these effects.

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Influenza A/Philippines/2/82 outbreak in a nursing home: Limitations of influenza vaccination in the aged

Cited by 37 publications

References 15 publications

Influenza in the Intensive Care Unit

Influenza in the Intensive Care Unit

Infections and antibiotic resistance in nursing homes

Influenza outbreak control practices and the effectiveness of interventions in long‐term care facilities: a systematic review

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