A comprehensive disaster-reduction demonstration community (CDRDC) is imperative for building community resilience when confronted with disasters. However, the temporal characteristics and spatial heterogeneity of CDRDC in China are rarely involved in relevant research, and the influencing factor selection dimension is relatively singular. Based on the list of CDRDCs in China from 2008 to 2020, this study analyzed the spatial–temporal evolution pattern of CDRDCs at different scales and explored the correlation between CDRDCs and influencing factors such as population, GDP, disaster frequency and natural disaster risk. We also deduced the theoretical distribution and the key development areas of CDRDCs, analyzed the problems faced by the establishment of CDRDCs in different regions of China, and put forward targeted optimization countermeasures for community-based disaster mitigation. The results are as follows: (1) The distribution of CDRDCs shows significant regional differences, with 50% concentrated in the eastern region. (2) The number of CDRDCs is closely related to population, GDP, and natural disaster risk, but it has a poor correlation with disaster frequency. (3) The capital circle, the Yangtze River Delta, the Pearl River Delta, eastern Fujian, and eastern Hubei will be the key development areas of CDRDCs in the future. The research results can provide a theoretical basis and technical support for the layout optimization of CDRDCs in China.