Influencing factors associated with lymph node status in patients with cutaneous melanoma: An Asian population study

Chu, Pen–Yuan; Chen, Yifan; Li, Cheng-Yuan; Wang, Tien‐Hsiang; Chiu, Yu–Jen; Ma, Hsu

doi:10.1097/jcma.0000000000000809

Cited by 4 publications

(6 citation statements)

References 36 publications

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“…Nodal status is the most important prognostic factor in melanoma, for which lymph node status assessment is crucial. 2 Here, we investigated the accuracy of PET/CT in evaluating the regional lymph node status and detecting distal metastases among Asians with acral melanoma. However, PET/CT showed poor sensitivity for the local lymph node status assessment, with a sensitivity of only 41.4% and specificity of 88.5%.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7] To evaluate regional nodal status, sentinel lymph node biopsy has become common in patients with melanoma without clinically palpable nodes. 2 According to American Society of Clinical Oncology and Society of Surgical Oncology, sentinel lymph node biopsy may be considered for tumor thickness between 0.8 and 1 mm or <0.8 mm with ulceration (T1b) and is often recommended when the tumor thickness exceeds 1 mm. 8 However, sentinel lymph node biopsy is invasive; thus, it features morbidities including, seroma, lymphedema, and infection.…”

Section: Introductionmentioning

confidence: 99%

“…1 The staging of melanoma is crucial because different stages require different treatments and feature different prognoses. 2 Surgical excision with adequate margins is the primary curative treatment for localized melanoma. If malignant cells are also present in the regional lymph nodes, nodal basin surveillance or complete lymph node dissection for local control has been recommended.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic value of 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography imaging in acral melanoma–predominant Asian patients

Chen,

Chu,

et al. 2023

Journal of the Chinese Medical Association

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Background: Tumor staging is crucial for melanoma, of which acral melanoma is the predominant subtype in Asians. 18F-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) and 18F-FDG-PET/computed tomography (18F-FDG-PET/CT) serve as non-invasive imaging tools for tumor staging. However, the literature is scarce on the diagnostic value of PET for acral melanoma. Methods: From January 1, 2006, to November 30, 2022, a total of 352 patients were diagnosed with melanoma at our hospital. Of them, 90 were diagnosed with cutaneous melanoma and underwent preoperative PET/CT for staging and sentinel lymph node biopsy or complete lymph node dissection. Staging of PET/CT was confirmed by histopathology or following imaging. The lymph node biopsy, distant metastasis status, and PET/CT imaging results were analyzed. Results: Of all the 90 patients with cutaneous melanoma, 72 of them were diagnosed as acral melanoma(80.0%). Compared with the histopathologic results, the lymph nodes were true-positive, true-negative, false-positive, and false-negative in 12, 54, seven, and 17 cases, respectively. The sensitivity of PET/CT for local lymph nodes was 41.4% (95% confidence interval [CI], 23.5–61.1%), while its specificity was 88.5% (95% CI, 77.8–95.3%). As for the detection of distal metastasis, the PET results were true-positive, true-negative, false-positive, and false-negative in six, 65, 15, and four cases, respectively. The sensitivity of PET for distal metastasis detection was 60.0% (95% CI, 26.2–87.8%), while its specificity was 81.3% (95% CI, 71.0–89.1%). Conclusion: Although non-invasive, PET/CT has relatively low sensitivity in regional lymph node evaluations and fair sensitivity in distal metastasis detection in Asian patients with acral melanoma. Thus, PET/CT may be more useful in patients with clinically palpable nodes or more advanced disease stage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnostic value of 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography imaging in acral melanoma–predominant Asian patients

Chen,

Chu,

et al. 2023

Journal of the Chinese Medical Association

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“…In MEN1 patients, this malignancy is either a possible consequence of the MEN1 gene defects, with loss of heterozygosity, or due to other gene and epigenetic anomalies (non- MEN1 ), and/or related to environmental factors such as persistent exposure to sunlight, etc. [ 120 , 121 , 122 , 123 , 124 , 125 ]. Therefore, close examination of skin lesions in patients with MEN1 might prove useful.…”

Section: Discussionmentioning

confidence: 99%

Approach of Multiple Endocrine Neoplasia Type 1 (MEN1) Syndrome–Related Skin Tumors

et al. 2022

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Non-endocrine findings in patients with MEN1 (multiple endocrine neoplasia) syndrome also include skin lesions, especially tumor-type lesions. This is a narrative review of the English-language medical literature including original studies concerning MEN1 and dermatological issues (apart from dermatologic features of each endocrine tumor/neuroendocrine neoplasia), identified through a PubMed-based search (based on clinical relevance, with no timeline restriction or concern regarding the level of statistical significance). We identified 27 original studies involving clinical presentation of patients with MEN1 and cutaneous tumors; eight other original studies that also included the genetic background; and four additional original studies were included. The largest cohorts were from studies in Italy (N = 145 individuals), Spain (N = 90), the United States (N = 48 and N = 32), and Japan (N = 28). The age of patients varied from 18 to 76 years, with the majority of individuals in their forties. The most common cutaneous tumors are angiofibromas (AF), collagenomas (CG), and lipomas (L). Other lesions are atypical nevi, basocellular carcinoma, squamous cell carcinoma, acrochordons, papillomatosis confluens et reticularis, gingival papules, and cutaneous T-cell lymphoma of the eyelid. Non-tumor aspects are confetti-like hypopigmentation, café-au-lait macules, and gingival papules. MEN1 gene, respective menin involvement has also been found in melanomas, but the association with MEN1 remains debatable. Typically, cutaneous tumors (AF, CG, and L) are benign and are surgically treated only for cosmetic reasons. Some of them are reported as first presentation. Even though skin lesions are not pathognomonic, recognizing them plays an important role in early identification of MEN1 patients. Whether a subgroup of MEN1 subjects is prone to developing these types of cutaneous lesions and how they influence MEN1 evolution is still an open issue.

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“…6 However, in Asian countries, melanoma is often diagnosed at more advanced stages, resulting in lower response rates to targeted therapy and immunotherapy, which, in turn, leads to a disproportionately high mortality rate. [7][8][9][10][11] These unique challenges are influenced by racial and regional differences in the disease profile. To address these challenges, substantial research efforts have been made in the development of melanoma treatment in Asian populations.…”

Section: Introductionmentioning

confidence: 99%

Comparative transcriptomic analysis reveals differences in gene expression and regulatory pathways between nonacral and acral melanoma in Asian individuals

Chiu,

Li,

Wang

et al. 2024

The Journal of Dermatology

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Melanoma predominantly occurs in White individuals, which is associated with factors such as exposure to UV radiation and skin pigmentation. Despite its low incidence, melanoma is the primary cause of skin cancer–related death in Asia, typically in areas with low sun exposure. In our previous whole‐exome sequencing study, we identified mutational signature 12 as the most prevalent variant in Asian patients, differing from the common UV‐associated mutational signature 7 observed in White individuals. We also observed major differences between acral melanoma (AM) and nonacral melanoma (NAM) in terms of signatures 7, 21, and 22. Notably, few studies have investigated the genomic differences between AM and NAM in Asian individuals. Therefore, in this study, we conducted transcriptomic sequencing to examine the disparities in RNA expression between AM and NAM. Ribosomal RNA depletion was performed to enhance the detection of functionally relevant coding and noncoding transcripts. Ingenuity pathway analysis revealed significant differences in gene expression and regulatory pathways between AM and NAM. The results also indicate that the genes involved in cell cycle signaling or immune modulation and programmed cell death protein 1/programmed cell death 1 ligand 1 signaling were differentially expressed in NAM and AM. In addition, high CDK4 expression and cell cycle variability were observed in AM, with high immunogenicity in NAM. Overall, these findings provide further insights into the pathogenesis of melanoma and serve as a reference for future research on this major malignant disease.

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Influencing factors associated with lymph node status in patients with cutaneous melanoma: An Asian population study

Cited by 4 publications

References 36 publications

Diagnostic value of 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography imaging in acral melanoma–predominant Asian patients

Diagnostic value of 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography imaging in acral melanoma–predominant Asian patients

Approach of Multiple Endocrine Neoplasia Type 1 (MEN1) Syndrome–Related Skin Tumors

Comparative transcriptomic analysis reveals differences in gene expression and regulatory pathways between nonacral and acral melanoma in Asian individuals

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