Influência do corticoide na cicatrização do manguito rotador de ratos – Estudo biomecânico

Dau, Leonardo; Abagge, Marcelo; Fruehling, Vagner Messias; Sola, Wilson Carlos; Lavrador, José Marcos; Cunha, Luiz Antônio Munhoz da

doi:10.1016/j.rbo.2013.10.002

Cited by 4 publications

(1 citation statement)

References 18 publications

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“… 8 , 9 , 12 However, local steroid injections also include the risk of tendon injury progression and other adverse effects. 13 – 16 Therefore, new therapeutic targets for painful RCT are needed.…”

Section: Introductionmentioning

confidence: 99%

Increased nerve growth factor expression in the synovial tissues of patients with rotator cuff tears

et al. 2021

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Background Rotator cuff tears (RCTs) are often associated with severe shoulder pain. Non-steroidal anti-inflammatory drugs, not recommended for long-term use, do not effectively manage RCT-induced pain, resulting in reduced quality of life. To improve management, a better understanding of the fundamental properties of RCT pain is needed. Here, we aimed to compare the expression levels of nerve growth factor (NGF) and cyclooxygenase-2 (COX-2) mRNA in the synovial tissues of patients with RCT-induced pain and patients with non-painful recurrent shoulder dislocation (RSD). Methods The study included 32 patients with RCT who underwent arthroscopic rotator cuff repair and 28 patients with non-painful RSD who underwent arthroscopic Bankart repair. Synovial tissue samples were harvested from subacromial bursa and rotator interval of RCT patients and from the rotator interval of RSD patients. Samples were analyzed quantitatively expression levels for NGF and COX2 mRNA and NGF protein. Results NGF mRNA and protein levels were significantly higher in the rotator interval of RCT patients than in the rotator interval of RSD patients ( p = 0.0017, p = 0.012, respectively), while COX2 mRNA levels did not differ significantly between the two patient groups. In RCT patients, COX2 mRNA was more highly expressed in the rotator interval than in the subacromial bursa ( p = 0.038), whereas the mRNA and protein levels of NGF did not differ between the two tissues. The expression of NGF mRNA in the synovium of the rotator interval was significantly correlated with the numeric rating scale of pain (ρ = 0.38, p = 0.004). Conclusion NGF mRNA and protein levels were elevated in patients with painful RCT compared with those in patients with non-painful RSD, whereas COX-2 levels were comparable in the two patient groups. These findings provide insights into novel potential strategies for clinical management of RCT.

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