Influencia de los anticuerpos antiperoxidasa tiroidea en los valores de TSH de gestantes y en las complicaciones materno-fetales

Martínez, Paula Fernández; García, Rocío Aguado; Galindo, David E. Barajas; Moreno, Ana Hernández; Ramos, Mirian Alejo; Arias, Sara; Ballesteros-Pomar, María D.; Rodríguez, Isidoro M Cano

doi:10.1016/j.endinu.2018.05.004

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…Further studies should be performed on better characterized groups of patients to evaluate the course of IgG-anti-F(ab')2 antibodies along pregnancy and their role in spontaneous abortion or other pregnancy complications. Considering the risks to the fetus in pregnant women with anti-thyroide antibodies [4][5][6][7], we recommend performing the screening for thyroid pathology together with the other screenings [23][24][25].…”

Section: Igg-anti-f(ab)2 Atbs Titer Is Higher In Women With a Normal Course Of Pregnancy Compared To Women Who Experienced A Spontaneous mentioning

confidence: 99%

“…The prevalence of these atbs in general population varies from 10-15% for anti-TPO to 3-6% for anti-TG and 1% for Trabs [1,4]. The most frequent consequences of the presence of anti-thyroid atbs are autoimmune thyroiditis and hypothyroidia, but in pregnancy the intrauterine milieu caused by the presence of these atbs could lead to impairment of various functions in the future child cardiometabolic syndrome, thyroid disease, IQ deficiencies [4,5,6], or pregnancy complications [7]. Other diseases found to be associated with anti-thyroid atbs are breast cancer [8], helicobacter pylori infections [9], systemic sclerosis [10], hyperprolactinemia [11], etc.…”

Section: Introductionmentioning

confidence: 99%

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IgG anti-(Fab�)2 Antibodies in Early Pregnancy Sera of Women with Anti-thyroid Antibodies and Normal Outcome or Spontaneous Abortions

Motoi¹,

Dobrescu²,

Carabineanu³

et al. 2020

Rev. Chim.

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Anti-thyroid antibodies (atbs) (anti-TPO, anti-TG, anti-TRH receptor) are autoatbs that recognize specific antigens that belong to thyroid structures. Several mechanisms were proposed to explain the breaking of immunotolerance to thyroid antigens. Our previous studies showed that IgG-anti-F(ab�)2 atbs exert immunosuppresives effect in vitro and inverse correlate with autoatbs in certain autoimmune diseases. Relying on sera from pregnant women with and without anti-thyroid atbs, respectively with or without spontaneous pregnancy loss we intended to analyze the IgG-anti-F(ab)2 atbs titers in sera of these categories of patients. The lot of patients consists of 126 pregnant women out of which 47 had a normal course of pregnancy and 79 experienced spontaneous abortion. Anti-TPO, anti-TG, and IgG-anti-F(ab�)2 atbs titers were measured in sera of these women. Although a difference was found between IgG-anti-F(ab�)2 atbs titer in pregnant women with positive versus negative anti-thyroid atbs, this was not statistically significant. IgG-anti-F(ab)2 atbs titer is higher in women with a normal course of pregnancy compared to women spontaneous pregnancy loss. Differently from other autoimmune diseases, our data show that IgG-anti-F(ab�)2 atbs are not inversely correlated to anti-thyroid atbs titers. Higher IgG-anti-(Fab�)2 atbs titers were found in pregnant women with normal course of pregnancy compared with those with pregnancy loss.

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Section: Igg-anti-f(ab)2 Atbs Titer Is Higher In Women With a Normal Course Of Pregnancy Compared To Women Who Experienced A Spontaneous mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

IgG anti-(Fab�)2 Antibodies in Early Pregnancy Sera of Women with Anti-thyroid Antibodies and Normal Outcome or Spontaneous Abortions

Motoi¹,

Dobrescu²,

Carabineanu³

et al. 2020

Rev. Chim.

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Prevalence of Components of Metabolic Syndrome Among Adults with the Presence of Autoimmune Thyroid Condition in an Iodine-Sufficient Region

Pan¹,

Zhang²,

Zhou

et al. 2020

Biol Trace Elem Res

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Evaluating the Progression to Hypothyroidism in Preconception Euthyroid Thyroid Peroxidase Antibody–Positive Women

Gill

Cheed

Morton

et al. 2022

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context Thyroid peroxidase antibody (TPOAb) positivity is prevalent in women of reproductive age and pre-disposes to thyroid dysfunction, namely hypothyroidism, which has adverse effects on pregnancy. Objectives To report the rate of development of abnormal thyroid function among initially euthyroid TPOAb positive women recruited into TABLET trial. To identify factors associated with the development of hypothyroidism. To compare outcomes between euthyroid and treated hypothyroid individuals. Design Observational cohort study. Setting Forty-nine UK hospitals between 2011-2016. Participants Euthyroid TPOAb-positive women aged 16-40years with a history of miscarriage or subfertility planning pregnancy, randomized to levothyroxine 50mcg daily or placebo. Main Outcome Measures Abnormal thyroid function, conception rate and live birth (LBR) ≥34weeks. Results 70/940 (7.4%) TPOAb-positive women developed subclinical (SCH) or overt (OH) hypothyroidism: 27/470 taking levothyroxine and 43/470 on placebo (relative risk (RR) 0.63; 95%CI 0.39-1.00; p = 0.05); 83% of cases emerging pre-pregnancy. Baseline median serum TSH concentrations and TPOAb titres were significantly higher in those who developed hypothyroidism compared to those who did not (p < 0.001). Treated SCH/OH demonstrated a higher failure-to-conceive rate compared to euthyroid women (adjusted RR 2.02 [1.56-2.62]; p < 0.001). The LBR ≥34weeks was similar in the treated SCH/OH and euthyroid groups (adjusted RR 1.09 [0.77-1.55]; p = 0.6). Conclusions Approximately 7% of euthyroid TPOAb-positive women will develop hypothyroidism within 1year preconception, or in pregnancy. Conception rates are lower in women with treated SCH/OH compared to euthyroid women, but live birth rates are comparable. Thyroid function in TPOAb-positive women should be monitored regularly, when trying to conceive, to ensure prompt diagnosis and appropriate treatment initiation. Precis Approximately 7% of euthyroid TPOAb positive women will develop hypothyroidism within 1 year preconception or in pregnancy. The risk is greater in women with higher baseline TSH concentrations. Prompt diagnosis and treatment of thyroid dysfunction ensures pregnancy outcomes are comparable to euthyroid individuals.

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Influencia de los anticuerpos antiperoxidasa tiroidea en los valores de TSH de gestantes y en las complicaciones materno-fetales

Cited by 4 publications

References 20 publications

IgG anti-(Fab�)2 Antibodies in Early Pregnancy Sera of Women with Anti-thyroid Antibodies and Normal Outcome or Spontaneous Abortions

IgG anti-(Fab�)2 Antibodies in Early Pregnancy Sera of Women with Anti-thyroid Antibodies and Normal Outcome or Spontaneous Abortions

Prevalence of Components of Metabolic Syndrome Among Adults with the Presence of Autoimmune Thyroid Condition in an Iodine-Sufficient Region

Evaluating the Progression to Hypothyroidism in Preconception Euthyroid Thyroid Peroxidase Antibody–Positive Women

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