Influencia de la leptina y la adiponectina sobre el cáncer de próstata

Abstract

Resumen.-OBJETIVO: Numerosos estudios han estudiado la asociación entre la obesidad, las sustancias secretadas por el tejido adiposo (leptina y adiponectina)

Complex relationship between sex hormones, insulin resistance and leptin in men with and without prostatic disease

“…The hypothesis considering that high leptin concentrations can influence evolution from latent PCa to a clinically detectable entity, is biologically possible. In vitro and in vivo studies show that this adipokine could promote angiogenesis, being an important factor for growing and dissemination of various kinds of neoplasias, including PCa [42,43]. These studies suggest that leptin should act as a promoter of tumor growth, favoring angiogenesis, vascular cells proliferation and inhibiting apoptosis, allowing progression, invasion and metastasis [43].…”

“…In vitro and in vivo studies show that this adipokine could promote angiogenesis, being an important factor for growing and dissemination of various kinds of neoplasias, including PCa [42,43]. These studies suggest that leptin should act as a promoter of tumor growth, favoring angiogenesis, vascular cells proliferation and inhibiting apoptosis, allowing progression, invasion and metastasis [43]. Singh et al evaluated the relationship between leptin and PCa, and its association with obesity.…”

Serum Adiponectin Level and Different Kinds of Cancer: A Review of Recent Evidence

“…The risk of endometrial cancer in women who had high circulating adiponectin levels was less than those with lower adiponectin levels [34]. Also, it seems that the risk of prostate cancer and benign prostatic hyperplasia in men with low adiponectin level is higher than others [44, 46]. Several cohort and case-control studies suggest an inverse relationship between serum levels of adiponectin, genomic changes, and colorectal cancer risk [36, 48].…”

“…HMW may be considered as a growth inhibitor for proliferation and prostate cancer cells [45]. Also in a study, serum adiponectin was called as a potential antiprostate cancer [46]. In another case-control study, adiponectin concentrations in patients with prostate cancer were less than controls [39].…”

Expression of AdipoR1 and AdipoR2 Receptors as Leptin-Breast Cancer Regulation Mechanisms

“…Adiponectin is a protein produced exclusively in white adipose tissue [ 8 ] and is considered as a protection hormone, carrying out an important role in the regulation of glucose through a potent sensitizing effect towards insulin, which affects the uptake of glucose in the muscle and participates in the homeostasis of lipids [ 9 ]. Its plasmatic concentration has an inversely proportional relationship towards obesity, body mass index, accumulation of visceral fat, and insulin resistance [ 10 , 11 ]. It carries out its function through two specific receptors, AdipoR1 and AdipoR2, which are receptors coupled to G proteins with six transmembrane domains.…”