2017
DOI: 10.1155/2017/4862016
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Expression of AdipoR1 and AdipoR2 Receptors as Leptin-Breast Cancer Regulation Mechanisms

Abstract: The development of breast cancer is influenced by the adipose tissue through the proteins leptin and adiponectin. However, there is little research concerning AdipoR1 and AdipoR2 receptors and the influence of leptin over them. The objective of this work was to analyze the expression of AdipoR1 and AdipoR2, modulated by differential concentrations of leptin in an obesity model (10 ng/mL, 100 ng/mL, and 1000 ng/mL) associated with breast cancer in MCF-7 and HCC1937 cell lines. Each cell line was characterized t… Show more

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Cited by 12 publications
(12 citation statements)
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“…Interestingly, synergistic pathway cross-talk most likely exists between the STAT3 and PPARA as they converge on upregulation of nuclear expression of CPT1 [228,229] driving FAO as an energy source in breast cancer-adipose associations. While adiponectin signaling functionally inhibits CPT1 activity (Figure 3), and has been correlated with of inhibition of STAT3 signalling in cancer, the differential expression of adiponectin receptors in the presence of leptin may reduce this inhibition, allowing for STAT3 mediation of adipocytokine signalling and promotion of breast cancer phenotypes allowing adipose tissue to create a fostering niche for cancer to thrive [230][231][232].…”
Section: Of 24mentioning
confidence: 99%
“…Interestingly, synergistic pathway cross-talk most likely exists between the STAT3 and PPARA as they converge on upregulation of nuclear expression of CPT1 [228,229] driving FAO as an energy source in breast cancer-adipose associations. While adiponectin signaling functionally inhibits CPT1 activity (Figure 3), and has been correlated with of inhibition of STAT3 signalling in cancer, the differential expression of adiponectin receptors in the presence of leptin may reduce this inhibition, allowing for STAT3 mediation of adipocytokine signalling and promotion of breast cancer phenotypes allowing adipose tissue to create a fostering niche for cancer to thrive [230][231][232].…”
Section: Of 24mentioning
confidence: 99%
“…NAP1L3 is overexpressed in breast cancer [280]. CCH1 , which is a voltage-gated high-affinity calcium channel with several homologs that were UES, including: CACNA1A , underexpressed in breast, colorectal, esophageal, gastric, and brain cancers; CACNA1B , underexpressed in breast and brain cancers; CACNA1C , underexpressed in brain, bladder, lung, lymphoma, prostate, and renal cancers; CACNA1E , underexpressed in breast, brain, gastric, leukemia, lung, and prostate cancers; and CACNA1F , underexpressed in lymphoma [274] ; IZH1 , a yeast membrane protein involved in zinc ion homeostasis, having a human homolog, PAQR1/ADIPOR1 that encodes the adiponectin receptor protein 1, which is differentially regulated in breast cancers [278,279] ; FAT1 , a yeast fatty acid transporter and very long-chain fatty acyl-CoA synthetase that corresponds to SLC27A2 (very long-chain acyl Co-A synthetase), which is underexpressed in lung cancer [275], and SLC27A3 (long-chain fatty acid transport), which is hypermethylated in melanoma [276]; FOL2/GCH1 , a GTP-cyclohydrolase that catalyzes the first step in folic acid biosynthesis. Downregulation of GCH1 occurs in esophageal squamous cell carcinoma [277].…”
Section: Resultsmentioning
confidence: 99%
“…Increased expression of leptin and its receptors was demonstrated in breast cancer cell lines and in human breast cancer tissues, since leptin and its receptors play important roles in apoptosis, cell proliferation and differentiation, mTOR (mammalian target of rapamycin) signaling, glucose regulation, inflammation, neurogenesis and gynecological diseases [3,4,[21][22][23]. Majority of the studies investigating the role of leptin and its receptors in breast cancer development were conducted with serum samples, mammary fat pad tissue or MT samples [21][22][23][24]. However, to the best of our knowledge, there is no previous study examining the association between the leptin and leptin receptor expression in liver and MT development.…”
Section: Discussionmentioning
confidence: 99%