Influência das modificações pós-traducionais de histonas H3K4ME2, H3K4ME3 e H3K14AC no prognóstico e na sobrevida do carcinoma de células escamosas bucal
Abstract:Studies on epigenetics in oral squamous cell carcinoma (OSCC) are rare. Post-translational histone modifications (MPTHs) are essential regulators of gene expression and are deregulated in cancers. In this research we investigated the expression of demethylation of H3K4 (H3K4me2), trimethylation of H3K4 (H3K4me3) and acetylation of H3K14 (H3K14ac) in OSCC and their relationship with metastasis and survival. Paraffin-embedded tissue samples of 90 OSCC patients were raised and submitted to immunohistochemical sta… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.