Influences of Sr, Zn and Mg Dopants on Osteoclast Differentiation and Resorption

Roy, Mousumi; Fielding, Gary; Bose, Susmita

doi:10.1002/9781118511466.ch22

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…78,79 The effects of Sr on bones, muscles and heart have been studied systemically, [79][80][81] and it is already considered to be a promising element and therefore introduced into new Mg alloys for biomedical applications. 82,83 New Mg alloys such as Mg-Sr [72][73][74] and Mg-Zr-Sr 56 have been developed that take into consideration the biocompatible benets of Sr and Zr. It has been demonstrated that an appropriate amount of Sr and Zr can improve the mechanical properties, corrosion behavior and biocompatibility of Mg alloys.…”

Section: Biodegradable Mg Alloysmentioning

confidence: 99%

Effects of alloying elements on the corrosion behavior and biocompatibility of biodegradable magnesium alloys: a review

et al. 2014

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Section: Biodegradable Mg Alloysmentioning

confidence: 99%

Effects of alloying elements on the corrosion behavior and biocompatibility of biodegradable magnesium alloys: a review

et al. 2014

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“…26 Zn is also a trace element for optional enzymes in the human body. 34 Sr can significantly improve the osteoblastic activity and bone formation in vivo, 35 and thus it has been used as a biocompatible alloying element of Mg alloys. 28 In addition, adverse consequences of overdoses of Zn on growth, development, and health have been reported.…”

Section: Introductionmentioning

confidence: 99%

“…The alloying element of Zr can improve the ductility, refine the grain size, and smoothen the grain boundaries of the Mg matrix, 33 and enhance the biomechanical properties and corrosion resistance of Mg alloys. 34 Sr can significantly improve the osteoblastic activity and bone formation in vivo, 35 and thus it has been used as a biocompatible alloying element of Mg alloys. 36,37 Considering the benefits in the biomechanical properties, biocorrosion and biocompatibility of Zr and Sr, a novel series of Mg-Zr-Sr alloys have been developed considering the various benefits of Sr and Zr in Mg alloys.…”

Section: Introductionmentioning

confidence: 99%

Effects of zirconium and strontium on the biocorrosion of Mg–Zr–Sr alloys for biodegradable implant applications

Ding

Lin³

et al. 2015

J. Mater. Chem. B

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The successful applications of magnesium (Mg) alloys as biodegradable orthopedic implants are mainly restricted due to their rapid degradation rate in the physiological environment, leading to a loss of mechanical integrity. This study systematically investigated the degradation behaviors of novel Mg-Zr-Sr alloys using electrochemical techniques, hydrogen evolution, and weight loss in simulated body fluid (SBF). The microstructure and degradation behaviors of the alloys were characterized using optical microscopy, XRD, SEM, and EDX. The results indicate that Zr and Sr concentrations in Mg alloys strongly affected the degradation rate of the alloys in SBF. A high concentration of 5 wt% Zr led to acceleration of anodic dissolution, which significantly decreased the biocorrosion resistance of the alloys and their biocompatibility. A high volume fraction of Mg 17 Sr 2 phases due to the addition of excessive Sr (over 5 wt%) resulted in enhanced galvanic effects between the Mg matrix and Mg 17 Sr 2 phases, which reduced the biocorrosion resistance. The average Sr release rate is approximately 0.15 mg L À1 day À1 , which is much lower than the body burden and proves its good biocompatibility. A new biocorrosion model has been established to illustrate the degradation of alloys and the formation of degradation products on the surface of the alloys. It can be concluded that the optimal concentration of Zr and Sr is less than 2 wt% for as-cast Mg-Zr-Sr alloys used as biodegradable orthopedic implants. Fig. 16 Schematic model for biocorrosion propagation of Mg-Zr-Sr alloys in SBF: (a) dissolution of the Mg matrix due to galvanic effects; (b) the partially protective film of Mg(OH) 2 ; (c) dissolution of Mg(OH) 2 due to deterioration by Cl À ; (d) formation of HA; (e) corrosive residues escaping from the Mg matrix.

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Influences of Sr, Zn and Mg Dopants on Osteoclast Differentiation and Resorption

Cited by 2 publications

References 13 publications

Effects of alloying elements on the corrosion behavior and biocompatibility of biodegradable magnesium alloys: a review

Effects of alloying elements on the corrosion behavior and biocompatibility of biodegradable magnesium alloys: a review

Effects of zirconium and strontium on the biocorrosion of Mg–Zr–Sr alloys for biodegradable implant applications

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