Influences of quorum‐quenching probiotic bacteria on the gut microbial community and immune function in weaning pigs

Kim, Jonggun; Kim, Jaepil; Kim, Young-Hoon; Oh, Sangnam; Song, Min Ho; Choe, Jae Gol; Whang, Kwang Youn; Kim, Kwang Hyun; Oh, Sejong

doi:10.1111/asj.12954

Cited by 28 publications

(20 citation statements)

References 29 publications

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“…A healthy gut microbiome is paramount to adequate systemic immune health. Several studies have demonstrated that microbial supplementation bolsters gut health and immune function in the presence of infection [23][24][25][26][27][28]. Modulation of gut immunity during the critical windows of weaning and creep feeding has the most influence on innate immunity and may maximize pig growth performance [29].…”

Section: Discussionmentioning

confidence: 99%

Dietary substitution of soybean oil with coconut oil in the absence of dietary antibiotics supports growth performance and immune function in nursery and grower pigs

Braundmeier-Fleming

Skenandore

Gil

et al. 2020

J Animal Sci Biotechnol

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Background: We hypothesized that supplementation of nursery and grower pig diets with coconut oil in the absence of antibiotics would yield maintenance of glucose homeostasis, growth performance, and immune function similar to what is achieved with nursery and grower pig diets containing antibiotics. Pigs received the same base treatment diets from d24 (weaning) to d71 of age and had blood and fecal samples collected on d24, d31, d45 and d71 for measurement of whole blood glucose, serum insulin, cortisol and cytokines, and fecal microbiome. Pigs had weekly weights and daily feed consumption measured throughout the study. Animals were euthanized at d71 and subcutaneous fat and ileal contents were collected for assessment for fatty acids and microbiome, respectively. Diet treatments consisted of 2% soybean oil plus antibiotics (ABX; n = 22), 2% soybean oil without antibiotics (NABX; n = 22), and 2% coconut oil without antibiotics (COC; n = 22). Statistical analysis examined the effect of diet within each timepoint using a repeated measures ANOVA. Results: Pigs fed COC diet had decreased serum insulin levels, maintained feed intake, feed conversion and weight gain, and, based on serum cytokines and fecal microbiome, were immunologically similar to ABX-fed pigs. However, NABX-fed pigs performed similarly to the ABX-fed pigs in all parameters except for serum cytokines. Additionally, there was no difference in the incidence of diarrhea between any of the diet treatments. Conclusions: This study demonstrates that dietary antibiotics are not necessary to maintain growth performance in nursery and grower pigs. However, dietary antibiotics appear to modulate circulating cytokine levels. Dietary coconut oil is neither harmful nor helpful to growth performance or immune function in nursery and grower pigs but does modulate serum insulin levels. Therefore, while coconut oil fed at 2% by weight is a suitable substitute for dietary antibiotics, this study suggests that no substitute for dietary antibiotics is needed at all.

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Section: Discussionmentioning

confidence: 99%

Dietary substitution of soybean oil with coconut oil in the absence of dietary antibiotics supports growth performance and immune function in nursery and grower pigs

Braundmeier-Fleming

Skenandore

Gil

et al. 2020

J Animal Sci Biotechnol

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“…Disruption of QS signaling may act as an antivirulence approach. For example, the addition of the probiotic Lactobacillus acidophilus to the feed of weaning pigs harboring EHEC in their gut inhibited the activity of AI-2 and prevented biofilm formation, without affecting the growth of EHEC (77). AI may also dictate the presence of a certain microbial species, thereby changing the overall metabolic landscape of the gut.…”

Section: Preventing Initial Colonizationmentioning

confidence: 99%

Taming the Beast: Interplay between Gut Small Molecules and Enteric Pathogens

2019

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The overuse of antibiotics has led to the evolution of drug-resistant bacteria that are becoming increasingly dangerous to human health. According to the Centers for Disease Control and Prevention, antibiotic-resistant bacteria cause at least 2 million illnesses and 23,000 deaths in the United States annually. Traditionally, antibiotics are bactericidal or bacteriostatic agents that place selective pressure on bacteria, leading to the expansion of antibiotic-resistant strains. In addition, antibiotics that are effective against some pathogens can also exacerbate their pathogenesis and may lead to severe progression of the disease. Therefore, alternative strategies are needed to treat antibiotic-resistant bacterial infections. One novel approach is to target bacterial virulence to prevent or limit pathogen colonization, while also minimizing tissue damage and disease comorbidities in the host. This review focuses on the interactions between enteric pathogens and naturally occurring small molecules in the human gut as potential therapeutic targets for antivirulence strategies. Individual small molecules in the intestines modulate enteric pathogen virulence and subsequent intestinal fitness and colonization. Targeted interruption of pathogen sensing of these small molecules could therefore attenuate their virulence. This review highlights the paths of discovery for new classes of antimicrobials that could potentially mitigate the urgent problem of antibiotic resistance.

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“…Probiyotik özelliklerin değerlendirilme işlemleri tamamlandıktan sonra, ilgili suşlar in vivo testlere tabi tutulmaktadır (De Melo Pereira et al, 2018). Probiyotiklerle ilgili olarak fare, sıçan ve domuzlarda in vivo testlerin yapıldığı çeşitli çalışmalar mevcuttur (Sarkar et al, 2016;Kim et al, 2018;Walcher et al, 2018). Ancak, çoğu kez artan maliyet ve etik nedenlerden dolayı in vivo testler yapılamamaktadır.…”

Section: Bağırsak Yüzeyine Tutunmaunclassified

Probiyotikler ve Belirlenmelerinde Kullanılan in vitro Testler

Bilginer¹,

Çeti̇n²

2019

Atatürk Üniversitesi Ziraat Fakültesi Dergisi

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ÖZ: Fonksiyonel gıdalara ve sağlıklı beslenmeye olan ilginin her geçen gün artması ile birlikte probiyotikler, bilim dünyasının önemli çalışma alanlarından biri haline gelmiştir. İnsan ve probiyotikler arasındaki mutual ilişkinin zamanla yeni boyutlar kazanması, konu üzerindeki çalışma sayısını ve probiyotik ürünlere olan ilgiyi daha da artırmaktadır. Probiyotik bir ürün üretmeden önce, o üründe kullanılacak mikroorganizmaların probiyotik olup olmadığının tespitinde ve güvenlik değerlendirmelerinde, in vitro ve in vivo testlerden faydalanılmaktadır. Bu derlemede, muhtemel probiyotik suşun insan gastrointestinal sistemiyle uyumuna yönelik olarak kullanılan; mide ortamına direnç, safra tuzuna tolerans, antibiyotik direnci, antagonistik etki, kolesterol asimilasyonu, bağırsak yüzeyine yapışma ve model gastrointestinal sistemler hakkında özet bilgi verilmeye çalışılmıştır.

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Influences of quorum‐quenching probiotic bacteria on the gut microbial community and immune function in weaning pigs

Cited by 28 publications

References 29 publications

Dietary substitution of soybean oil with coconut oil in the absence of dietary antibiotics supports growth performance and immune function in nursery and grower pigs

Dietary substitution of soybean oil with coconut oil in the absence of dietary antibiotics supports growth performance and immune function in nursery and grower pigs

Taming the Beast: Interplay between Gut Small Molecules and Enteric Pathogens

Probiyotikler ve Belirlenmelerinde Kullanılan in vitro Testler

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