Influences of protein ingestion on glucagon‐like peptide (<scp>GLP</scp>)‐1‐immunoreactive endocrine cells in the chicken ileum

Monir, Mohammad M.; Hiramatsu, Kohzy; Matsumoto, Sachiko; Nishimura, Kinya; Takemoto, Chihiro; Shioji, Tomomi; Watanabe, Takafumi; Kita, Kazumi; Yonekura, Shinichi; Roh, Sang Gun

doi:10.1111/asj.12177

Cited by 14 publications

(22 citation statements)

References 33 publications

(72 reference statements)

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“…The mRNA of proglucagon, which acts as the precursor of GLP-1, is highly expressed in the ileum of the chicken alimentary tract (Honda et al, 2017). In chickens, GLP-1 is stored in the secretory granules of L cells, which are mainly distributed in the distal ileum (Hiramatsu et al, 2003(Hiramatsu et al, , 2005Nishimura et al, 2013) and is secreted in response to dietary protein and amino acids (Monir et al, 2014a;Nishimura et al, 2015). GLP-1 secreted from L cells binds to its specific receptor, GLP-1R.…”

Section: Introductionmentioning

confidence: 99%

Glucagon-like Peptide-1 Receptor Expression in the Pancreatic D Cells of Three Avian Species; White Leghorn Chickens, Northern Bobwhites, and Common Ostriches

et al. 2018

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Glucagon-like peptide (GLP)-1 is released from the intestinal L cells in response tofood ingestion and stimulates insulin secretion from the pancreatic B cells, by binding to its specific receptor (GLP-1R), which is expressed on the pancreatic B cells in the mammalian pancreas. Previously, we demonstrated that chicken GLP-1R was expressed on the pancreatic D cells by using a specific antibody against chicken GLP-1R. In the present study, we compared the localization of GLP-1R in the pancreases of three avian species; white leghorn chicken, northern bobwhite, and common ostrich, using the double immunofluorescence technique. We found that the types of pancreatic islets in the northern bobwhite pancreas were similar to those found

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Section: Introductionmentioning

confidence: 99%

Glucagon-like Peptide-1 Receptor Expression in the Pancreatic D Cells of Three Avian Species; White Leghorn Chickens, Northern Bobwhites, and Common Ostriches

et al. 2018

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“…Our previous studies in chicken small intestine showed that the L cells were open-typed endocrine cells that were covered apically with microvilli (Nishimura et al, 2013) and they were influenced by protein ingestion (Monir et al, 2014a). Protein is digested to amino acids and absorbed by enterocytes of the small intestine where the L cells are distributed (Hiramatsu et al, 2003.…”

Section: Discussionmentioning

confidence: 99%

Amino Acid Supplementation to Diet Influences the Activity of the L Cells in Chicken Small Intestine

et al. 2015

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Glucagon-like peptide-1 (GLP-1) is secreted by L cells in the small intestine in response to food ingestion. The influence of supplementation to diet with the amino acids, methionine (Met) and lysine (Lys), on the L cells in chicken small intestine was investigated using immunohistochemical and morphometrical techniques. Many endocrine cells showing immunoreactivity for GLP-1 antiserum were observed in the control, crude protein (CP) 0%, CP 0%＋Met and CP 0%＋Lys groups. The GLP-1-immunoreactive cells in all the groups were "open-typed" endocrine cells as viewed under light and electron microscopes. Differences in the shape and distributional pattern of GLP-1-immunoreactive cells were not observed between the control and experimental groups. Frequencies of the occurrence of GLP-1-immunoreactive cells in the CP 0%＋Met and CP 0%＋Lys groups were significantly lower than that of the CP 0% group, but significant differences were not recognized between the control group and the CP 0%＋Met and CP 0%＋Lys groups. Secretory granules in the control group were round to oval in shape. Elongated secretory granules were observed in the experimental groups, but not in the control group. Ratios of GLP-1-immunoreactive cells with elongated secretory granules in the CP 0%＋Met and CP 0%＋Lys groups were decreased compared with that in the CP 0% group. The size of round secretory granules in the control group was larger than that in all the groups. However, sizes of round secretory granules in the CP 0%＋Met and CP 0%＋Lys groups were larger than that in the CP 0% group. These morphological results indicate that amino acids may be a signal that influences on the secretion of GLP-1 in chicken small intestine.

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“…However, restriction feeding significantly increased GLP-1-immunoreactive cells in the chicken small intestine (Monir et al, 2014c). Multiple regression analysis indicated a significant correlation between the daily protein intake and frequencies of occurrence of GLP-1-immunoreactive cells (Monir et al, 2014a). GLP-2 colocalized with GLP-1 in the same secretory granules in the ileum (Nishimura et al, 2013).…”

Section: Al 2003)mentioning

confidence: 91%

“…Lines of evidence have suggested that GLP-2 acts as one of the common hormones secreted by L cells in the small intestine in chickens. For example, GLP-2 colocalized with GLP-1 in the same secretory granules in chicken intestinal L cells (Monir et al, 2014b;Nishimura et al, 2013), and dietary protein and restriction feeding positively and negatively stimulated GLP-1-immunoreactive cells, respectively (Monir et al, 2014a, c). It is therefore possible that GLP-2 functioning as endocrine and neural signals may transmit intestinal nutrient sensing to the central nervous system to suppress food intake in chickens as well as in mammals.…”

Section: Introductionmentioning

confidence: 99%

Glucagon-like Peptide-2 Functions as an Anorexigenic Peptide not only in the Central Nervous System but also in the Peripheral Circulation in Broiler Chicks

et al. 2015

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Brain-gut peptides play important roles in the appetite regulatory system in mammals. Glucagon-like peptide (GLP)-1, GLP-2, and oxyntomodulin (OXM) are processed from the same precursor, proglucagon, in both brain and intestines in mammals and birds. We previously showed that intracerebroventricular administration of these three peptides significantly suppressed food intake in chicks. However, peripheral roles of chicken GLP-2 have not yet been investigated, although GLP-2 plays important roles both in central and peripheral regulation of food intake in mammals. The aim of this study is to investigate whether GLP-2 functions as an anorexigenic peptide in both brain and peripheral circulation in chicks. Intracerebroventricular administration of GLP-2 significantly suppressed food intake in chicks. Twenty-four hours of fasting significantly decreased the mRNA level of proglucagon in the medulla oblongata of chicks. These results suggest that GLP-2 functions as anorexigenic peptides in the central nervous system in chicks. In addition, intravenous administration of GLP-2 significantly suppressed food intake in chicks. Lines of evidence suggest that dietary nutrients stimulate the secretion of GLP-2 from L cells in the small intestine in chickens. These findings suggest that GLP-2 functions as both central and peripheral anorexigenic signals in chicks.

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Influences of protein ingestion on glucagon‐like peptide (GLP)‐1‐immunoreactive endocrine cells in the chicken ileum

Abstract: ABSTRACT

Cited by 14 publications

References 33 publications

Glucagon-like Peptide-1 Receptor Expression in the Pancreatic D Cells of Three Avian Species; White Leghorn Chickens, Northern Bobwhites, and Common Ostriches

Glucagon-like Peptide-1 Receptor Expression in the Pancreatic D Cells of Three Avian Species; White Leghorn Chickens, Northern Bobwhites, and Common Ostriches

Amino Acid Supplementation to Diet Influences the Activity of the L Cells in Chicken Small Intestine

Glucagon-like Peptide-2 Functions as an Anorexigenic Peptide not only in the Central Nervous System but also in the Peripheral Circulation in Broiler Chicks

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