Influences of physical and chemical crosslinking techniques on electrospun type A and B gelatin fiber mats

Preparation of Starch/Gelatin Blend Microparticles by a Water-in-Oil Emulsion Method for Controlled Release Drug Delivery

“…The starch/gelatin blend solution was crosslinked with a glutaraldehyde solution before the blend microparticle formation. The resulting microparticles were washed with 0.1 M glycine, followed by deionized water to eliminate the aldehyde residue [14] before being kept in a desiccator before characterisation of their properties and drug release testing.…”

Physical stabilisation of electrospun poly(vinyl alcohol) nanofibres: comparative study on methanol and heat-based crosslinking

“…Despite having advantageous properties, it suffers from instability in water and hence this is a major challenge to its full application potential [7]. Crosslinking of electrospun PVA nanofibres is carried out to remove this problem by many researchers [1,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Crosslinking forms a three-dimensional network by joining polymer chains with one another and therefore increases fibre stability as well as other physical properties.…”

Novel electrospun gelatin/oxycellulose nanofibers as a suitable platform for lung disease modeling

“…Still, gelatin nanofibers dissolve in water so that they require crosslinking process to improve their hydrolytic stability along with enhancing their mechanical properties [35]. Variety of chemical and physical modalities are available to achieve crosslinking of gelatin including aldehydes (formaldehyde, glutaraldehyde, and glyceraldehyde) [36], genipin [37], polyepoxides [38], acyl azide [39], isocyanates [40], carbodiimides [41,42], enzymatically or naturally derived crosslinking agents [43], dehydrothermal treatment (DHT) and ultraviolet or gamma irradiation [44].…”