Novel electrospun gelatin/oxycellulose nanofibers as a suitable platform for lung disease modeling

Pavliňáková, Veronika; Vojtová, Lucy; Pavliňák, David; Vojtek, Libor; Sedláková, Veronika; Hyršl, Pavel; Alberti, Milan; Jaroš, Josef; Hampl, Aleš; Jančář, J.

doi:10.1016/j.msec.2016.05.059

Cited by 30 publications

(9 citation statements)

References 53 publications

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“…However, gelatin is difficult to use in specific in vivo affected areas where stress is repeatedly loaded, since it has a significant strength limitation. Various coupling or cross-linking agents such as glutaraldehyde (GA), formaldehyde, and methacryloyl derivatives have been used to strengthen the hydrolytic and enzymatic stabilities [13,14] and the mechanical properties of gelatins. Although it has been reported that GA treatment increases the mechanical strength and resistance to degradation of gelatin [15,16], the cytocompatibility of GA-treated gelatin tends to be reduced [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Cellular Orientation on Repeatedly Stretching Gelatin Hydrogels with Supramolecular Cross-Linkers

et al. 2019

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The cytocompatibility of biological and synthetic materials is an important issue for biomaterials. Gelatin hydrogels are used as biomaterials because of their biodegradability. We have previously reported that the mechanical properties of gelatin hydrogels are improved by cross-linking with polyrotaxanes, a supramolecular compound composed of many cyclic molecules threaded with a linear polymer. In this study, the ability of gelatin hydrogels cross-linked by polyrotaxanes (polyrotaxane–gelatin hydrogels) for cell cultivation was investigated. Because the amount of polyrotaxanes used for gelatin fabrication is very small, the chemical composition was barely altered. The structure and wettability of these hydrogels are also the same as those of conventional hydrogels. Fibroblasts adhered on polyrotaxane–gelatin hydrogels and conventional hydrogels without any reduction or apoptosis of adherent cells. From these results, the polyrotaxane–gelatin hydrogels have the potential to improve the mechanical properties of gelatin without affecting cytocompatibility. Interestingly, when cells were cultured on polyrotaxane–gelatin hydrogels after repeated stress deformation, the cells were spontaneously oriented to the stretching direction. This cellular response was not observed on conventional hydrogels. These results suggest that the use of a polyrotaxane cross-linking agent can not only improve the strength of hydrogels but can also contribute to controlling reorientation of the gelatin.

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Section: Introductionmentioning

confidence: 99%

Cellular Orientation on Repeatedly Stretching Gelatin Hydrogels with Supramolecular Cross-Linkers

et al. 2019

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“…Oxycellulose has wide applications as medical supplies, for instance, oxycellulose can be used for drug delivery, [ 28 ] or used to wrap liquefied fat during transsphenoidal surgery, [ 29 ] or to fabricate gelatin/oxycellulose nanofibers which is a promising scaffold for lung disease modeling and anticancer drug testing. [ 30 ]…”

Section: Resultsmentioning

confidence: 99%

Revisiting Alkaline Pretreatment of Lignocellulose: Understanding the Structural Evolution of Three Components

Zhu

Liu

et al. 2020

Advanced Sustainable Systems

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chemicals (for instance, monophenols) is difficult because of its structural heterogeneity and bio-recalcitrance nature. [3] Therefore, valorization of lignocellulose is mostly started with its fractionation into three components, which is of great importance for the exploration of the maximum potential value of lignocellulose. To date, many methods have been used to fractionate or/and convert lignocellulose, such as acidic pretreatment, [4] alkaline pretreatment, [5-9] reductive catalytic fractionation (RCF), [10-12] oxidative catalytic fractionation (OCF), [13] organosolv pretreatment, [14] ionic liquids pretreatment, [15,16] and deep eutectic solvent extraction (DES). [17,18] Wherein, alkaline pretreatment is one of the most used and efficient pretreatment, which has been widely employed in pulping industry and researches. [5] Nowadays, many alkaline pretreatment technologies have been developed, such as ammonia pretreatment, lime (Ca(OH) 2) pretreatment, sodium hydroxide (NaOH) and sodium carbonate (Na 2 CO 3) pretreatments. By using these methods, hemicellulose and lignin can be dissolved in the alkaline solution, while cellulose can be obtained as solid residue. In general, the fractionation rate of the lignin increases accordingly with the hydroxyl ions concentration. [5,19] Therefore, strong base, i.e., NaOH pretreatment has the highest efficiency on delignification, and so as the hemicellulose dissolution, when compared to other alkaline pretreatments. Thus, NaOH pretreatment has been drawing increasing attention for over hundred years by researchers and is widely used in industrial production. [5-9] However, the products in the downstream are complicated and unknown in the NaOH pretreatment. In recent years, conversion of lignin has been drawing increasing attentions and lignin is reported to be converted into many value-added chemicals that have variety of applications, by up-to-date technologies. [12,20-22] To extract more value from lignocellulose, not only conversion of carbohydrate, but also valorization of lignin should be taken into account. Before their valorization, chemical characters of carbohydrate and lignin should be clear. However, most of the researches aimed to obtain carbohydrates and to enzymatic hydrolysis of carbohydrates. [6-8] Chemical structure of three components after NaOH pretreatment, especially lignin, remains unclear. In this work, pine (softwood), comprising mainly of G-type

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“…Such nanofiber properties as great porosity and high surface area make this nanomaterial interesting for applications focusing on filtration, fibrous reinforcements in synthetic or biological composites, electronic devices, or tissue engineering [1]. The nanofibers themselves are tender material and are very sensitive to mechanical manipulation.…”

Section: Introductionmentioning

confidence: 99%

Diffuse Coplanar Surface Barrier Discharge Plasma Treatment as a Part of Technology for Manufacturing of Nanofiber-Based Filters

Galmiz

Fleischer

Pavliňák

et al. 2021

NANOCON 2021 Conference Proeedings

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Nanofiber membranes are made of synthetic polymers mainly by electrospinning technology. The key point for creating a functional nanofiber membrane for water and air filters is to meet basic key properties such as filtration efficiency, mechanical resistance, and resistance to fouling and chemicals. Design and manufacturing of the advanced nanofiber-based filters urgently require new environment-friendly and cost-effective surface treatments without the use of organic solvents and caustic solutions. To address this need, as an alternative, the atmospheric-pressure plasma treatment offers to be used for surface activation of polymer textile materials serving as a substrate for electrospun nanofiber. Nanofiber carriers represented by polypropylene non-woven were pre-treated by dielectric barrier discharge in continuous mode to improve the adhesion between the produced nanofibers and substrate. The increased adhesive forces to carrier substrate were confirmed by two peeling tests. The fact that the robust and effective atmospheric-pressure diffuse coplanar surface barrier discharge technology, primarily developed and optimized for the plasma treatment of textile and fibrous material, can be easily implemented in the industrial production lines predetermines this technology for in-line a large throughput manufacturing of advanced nanofiber-based filters.

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Novel electrospun gelatin/oxycellulose nanofibers as a suitable platform for lung disease modeling

Cited by 30 publications

References 53 publications

Cellular Orientation on Repeatedly Stretching Gelatin Hydrogels with Supramolecular Cross-Linkers

Cellular Orientation on Repeatedly Stretching Gelatin Hydrogels with Supramolecular Cross-Linkers

Revisiting Alkaline Pretreatment of Lignocellulose: Understanding the Structural Evolution of Three Components

Diffuse Coplanar Surface Barrier Discharge Plasma Treatment as a Part of Technology for Manufacturing of Nanofiber-Based Filters

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