Influences of ionic dissolution products of dicalcium silicate coating on osteoblastic proliferation, differentiation and gene expression

Sun, Junying; Li, Wei; Liu, Xuanyong; Li, Jianyou; Li, Baoe; Wang, Guocheng; Meng, Fanbin

doi:10.1016/j.actbio.2008.10.011

Cited by 153 publications

(113 citation statements)

References 38 publications

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“…The key determining factor for these differences is thought to be the Si ions and the higher amount of Ca ions released from CaSiO 3 ceramics than b-TCP ceramics [53]. Sun et al [18] reported that Ca and Si ions released from plasma-sprayed Ca 2 SiO 4 coatings enhanced the expression of osteoblast differentiation markers including alkaline phosphatase, osteocalcin and type I collagen. Therefore, it is plausible to suggest that the enhanced HOB differentiation seen on the HT and SP coatings is due to the release of Ca and Si ions from the coatings.…”

Section: Discussionmentioning

confidence: 99%

Nanostructured glass–ceramic coatings for orthopaedic applications

Wang

Liu

et al. 2011

J. R. Soc. Interface.

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Glass -ceramics have attracted much attention in the biomedical field, as they provide great possibilities to manipulate their properties by post-treatments, including strength, degradation rate and coefficient of thermal expansion. In this work, hardystonite (HT; Ca 2 ZnSi 2 O 7 ) and sphene (SP; CaTiSiO 5 ) glass -ceramic coatings with nanostructures were prepared by a plasma spray technique using conventional powders. The bonding strength and Vickers hardness for HT and SP coatings are higher than the reported values for plasma-sprayed hydroxyapatite coatings. Both types of coatings release bioactive calcium (Ca) and silicon (Si) ions into the surrounding environment. Mineralization test in cell-free culture medium showed that many mushroom-like Ca and phosphorus compounds formed on the HT coatings after 5 h, suggesting its high acellular mineralization ability. Primary human osteoblasts attach, spread and proliferate well on both types of coatings. Higher proliferation rate was observed on the HT coatings compared with the SP coatings and uncoated Ti-6Al-4V alloy, probably due to the zinc ions released from the HT coatings. Higher expression levels of Runx2, osteopontin and type I collagen were observed on both types of coatings compared with Ti-6Al-4V alloy, possibly due to the Ca and Si released from the coatings. Results of this study point to the potential use of HT and SP coatings for orthopaedic applications.

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Section: Discussionmentioning

confidence: 99%

Nanostructured glass–ceramic coatings for orthopaedic applications

Wang

Liu

et al. 2011

J. R. Soc. Interface.

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“…Recently, silicate-based bioceramics have received significant attention in bone tissue engineering due to the ability for regulating the cell behaviors [12–17]. β-Ca 2 SiO 4 ceramic is one of the bioactive ceramics [18] and can significantly induce the formation of hydroxyapatite layer on its surface in simulated body fluid (SBF) [19,20], showing the excellent bioactivity.…”

Section: Introductionmentioning

confidence: 99%

3D printed porous β-Ca₂SiO₄scaffolds derived from preceramic resin and their physicochemical and biological properties

Liu

et al. 2018

Science and Technology of Advanced Materials

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Silicate bioceramic scaffolds are of great interest in bone tissue engineering, but the fabrication of silicate bioceramic scaffolds with complex geometries is still challenging. In this study, three-dimensional (3D) porous β-Ca2SiO4 scaffolds have been successfully fabricated from preceramic resin loaded with CaCO3 active filler by 3D printing. The fabricated β-Ca2SiO4 scaffolds had uniform interconnected macropores (ca. 400 μm), high porosity (>78%), enhanced mechanical strength (ca. 5.2 MPa), and excellent apatite mineralization ability. Importantly, the results showed that the increase of sintering temperature significantly enhanced the compressive strength and the scaffolds sintered at higher sintering temperature stimulated the adhesion, proliferation, alkaline phosphatase activity, and osteogenic-related gene expression of rat bone mesenchymal stem cells. Therefore, the 3D printed β-Ca2SiO4 scaffolds derived from preceramic resin and CaCO3 active fillers would be promising candidates for bone tissue engineering.

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“…High levels of Lrp5 are associated with high bone mass and promote osteoblast proliferation [32] ; while the over-expression of Dkk1 causes reduced osteoblast differentiation and subsequent mineralization [33] . It was reported that biomaterials containing Si could induce BMP-2 expression in osteoblast-like cells [34] . Moreover, Zhang et al [35] proved that BMP-2 could stimulate Lrp5 expression and inhibit Dkk1 expression in MC3T3-E1 cells.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Performance of Osteoblasts by Silicon Incorporated Porous TiO2 Coating

Wang

Qiao

et al. 2012

Journal of Materials Science & Technology

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Influences of ionic dissolution products of dicalcium silicate coating on osteoblastic proliferation, differentiation and gene expression

Cited by 153 publications

References 38 publications

Nanostructured glass–ceramic coatings for orthopaedic applications

Nanostructured glass–ceramic coatings for orthopaedic applications

3D printed porous β-Ca₂SiO₄scaffolds derived from preceramic resin and their physicochemical and biological properties

Enhanced Performance of Osteoblasts by Silicon Incorporated Porous TiO2 Coating

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Influences of ionic dissolution products of dicalcium silicate coating on osteoblastic proliferation, differentiation and gene expression

Cited by 153 publications

References 38 publications

Nanostructured glass–ceramic coatings for orthopaedic applications

Nanostructured glass–ceramic coatings for orthopaedic applications

3D printed porous β-Ca2SiO4scaffolds derived from preceramic resin and their physicochemical and biological properties

Enhanced Performance of Osteoblasts by Silicon Incorporated Porous TiO2 Coating

Contact Info

Product

Resources

About

3D printed porous β-Ca₂SiO₄scaffolds derived from preceramic resin and their physicochemical and biological properties