Nanostructured glass–ceramic coatings for orthopaedic applications

Wang, Guocheng; Lu, Zufu; Liu, Xuanyong; Zhou, Xiaomeng; Ding, Chuanxian; Zreiqat, Hala

doi:10.1098/rsif.2010.0680

Cited by 37 publications

(34 citation statements)

References 55 publications

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“…The surface modified technology was a good way to improve alloys' surface morphology, chemical composition and microstructure, which were thought to be important factors for implants' biological performance [10,11]. Calcium-phosphate ceramic are usually coated on the titanium alloys for its bioactivity on bone formation and bonding [12].…”

Section: Introductionmentioning

confidence: 99%

The in vitro and in vivo performance of a strontium-containing coating on the low-modulus Ti35Nb2Ta3Zr alloy formed by micro-arc oxidation

Liu

Cheng

Wahafu

et al. 2015

J Mater Sci: Mater Med

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The β-titanium alloy is thought to be a promising alloy using as orthopedic or dental implants owing to its characteristics, which contains low elastic modulus, high corrosion resistance and well biocompatibility. Our previous study has reported that a new β-titanium alloy Ti35Nb2Ta3Zr showed low modulus close to human bone, equal tissue compatibility to a traditional implant alloy Ti6Al4V. In this study, micro-arc oxidation (MAO) was applied on the Ti35Nb2Ta3Zr alloy to enhance its surface characteristics and biocompatibility and osseointegration ability. Two different coatings were formed, TiO2 doped with calcium-phosphate coating (Ca-P) and calcium-phosphate-strontium coating (Ca-P-Sr). Then we evaluated the effects of the MAO coatings on the Ti35Nb2Ta3Zr alloy through in vitro and in vivo tests. As to the characteristics of the coatings, the morphology, chemical composition, surface roughness and contact angle of MAO coatings were tested by scanning electron microscopy, energy dispersive spectroscopy, atomic force microscopy, and video contact-angle measurement system respectively. Besides, we performed MTT assay, ALP test and cell morphology-adhesion test on materials to evaluate the MAOed coating materials' biocompatibility in vitro. The in vivo experiment was performed through rabbit model. Alloys were implanted into rabbits' femur shafts, then we performed micro-CT, histological and sequential fluorescent labeling analysis to evaluate implants' osseointegration ability in vivo. Finally, the Ca-P specimens and Ca-P-Sr specimens exhibited a significant enhancement in surface roughness, hydrophilicity, cell proliferation, cell adhesion. More new bone was found around the Ca-P-Sr coated alloy than Ca-P coated alloy and Ti35Nb2Ta3Zr alloy. In conclusion, the MAO treatment improved in vitro and in vivo performance of Ti35Nb2Ta3Zr alloy. The Ca-P-Sr coating may be a promising modified surface formed by MAO for the novel β-titanium alloy Ti35Nb2Ta3Zr.

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Section: Introductionmentioning

confidence: 99%

The in vitro and in vivo performance of a strontium-containing coating on the low-modulus Ti35Nb2Ta3Zr alloy formed by micro-arc oxidation

Liu

Cheng

Wahafu

et al. 2015

J Mater Sci: Mater Med

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“…However, owing to the rather passive properties of Ti, the osseointegration of Ti can be improved and the early effect of the implants remains unsatisfying [3][4][5]. Therefore, creating a bioactive surface for the TC is helpful to promote cell-material interactions and improve osseointegration of the implants [6,7].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and in vitro evaluation of stable collagen/hyaluronic acid biomimetic multilayer on titanium coatings

Xie

Tan

et al. 2013

J. R. Soc. Interface.

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Layer-by-layer (LBL) self-assembly technique has been proved to be a highly effective method to immobilize the main components of the extracellular matrix such as collagen and hyaluronic acid on titanium-based implants and form a polyelectrolyte multilayer (PEM) film by electrostatic interaction. However, the formed PEM film is unstable in the physiological environment and affects the long-time effectiveness of PEM film. In this study, a modified LBL technology has been developed to fabricate a stable collagen/hyaluronic acid (Col/HA) PEM film on titanium coating (TC) by introducing covalent immobilization. Scanning electron microscopy, diffuse reflectance Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy were used to characterize the PEM film. Results of Sirius red staining demonstrated that the chemical stability of PEM film was greatly improved by covalent crosslinking. Cell culture assays further illustrated that the functions of human mesenchymal stem cells, such as attachment, spreading, proliferation and differentiation, were obviously enhanced by the covalently immobilized Col/ HA PEM on TCs compared with the absorbed Col/HA PEM. The improved stability and biological properties of the Col/HA PEM covalently immobilized TC may be beneficial to the early osseointegration of the implants.

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“…To overcome these drawbacks, the design of the chemical composition and topography of the TiO 2 coating can be considered. Chemically, the biocompatible trace elements including Sr, Si and Zn have been utilized and their beneficial effects on the improvement of biological performance of implant have been proved [5][6][7]. Physically, it was reported that topography of implants can influence the cell behaviors including activation, adhesion, orientation, morphology and movement [8].…”

Section: Introductionmentioning

confidence: 99%