Influences of Genetic and Environmental Factors on Chronic Migraine: A Narrative Review

Yeh, Po-Kuan; An, Yu-Chin; Hung, Kuo-Sheng; Yang, Fu-Chi

doi:10.1007/s11916-024-01228-4

Cited by 6 publications

(2 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Environmental factors play a significant role in triggering headaches, particularly migraines, and can contribute to the progression from episodic to chronic migraines, especially in genetically predisposed individuals. Stress, sleep disturbances, hormonal changes, weather patterns, dietary factors, and sensory stimuli are among the critical triggers [19]. Additionally, noise exposure has been linked to increased pain severity and decreased tolerance to aversive stimuli in headache patients [20].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Exploring Headaches in Pediatric Behçet Disease: Prevalence, Clinical Impact, and Management

Santangelo,

Corsello,

Gizzi

et al. 2024

JCM

View full text Add to dashboard Cite

Behçet’s Disease (BD), also recognized as Behçet Syndrome, manifests uniquely in pediatric populations as Pediatric Behçet’s Disease (PBD), characterized by multisystemic inflammatory symptoms including recurrent oral and genital aphthae, and diverse ocular, vascular, and neurological involvements. This review elucidates the prevalence, burden, and management strategies of headaches in children with PBD, focusing on both primary headaches, such as migraine and tension-type headaches, and secondary headaches linked to systemic disease manifestations. It explores the pathophysiological underpinnings specific to PBD-related headaches and discusses the intricate relationship between systemic inflammatory processes and neurological symptoms. By examining the literature from 2004 to 2024, this study highlights the high frequency of headache in PBD patients, underscoring its diagnostic and clinical significance. We aim to provide a detailed understanding of headache management in PBD, emphasizing tailored therapeutic strategies that address the unique challenges faced by this patient population. This review also underscores the importance of comprehensive clinical evaluations to optimize outcomes and mitigate long-term sequelae, proposing that awareness and understanding of headache in PBD can significantly enhance both diagnosis and management.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Primary headaches represent the most prevalent complaints among the pediatric population, significantly impacting physical and psychological well-being. Migraine and TTH rank as the most common types, followed by chronic headaches and probable medicationoveruse headaches [13,[19][20][21][22][23].…”

Section: Primary Headaches In Bdmentioning

confidence: 99%

Exploring Headaches in Pediatric Behçet Disease: Prevalence, Clinical Impact, and Management

Santangelo,

Corsello,

Gizzi

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

Lack of association between TRPV1 gene polymorphisms and risk of migraine chronification: a case-control study and meta-analysis

Giacon,

Cargnin,

Allena

et al. 2024

Neurol Sci

View full text Add to dashboard Cite

Objective To confirm a previously reported association of TRPV1 rs8065080 with the risk of transformation from episodic (EM) to chronic migraine (CM) and to extend knowledge about the role of other TRPV1 single nucleotide polymorphisms (SNPs), we first investigated the impact of three TRPV1 SNPs (rs8065080, rs222747 and rs222749) on the risk of migraine chronification in a case-control study. A systematic review and meta-analysis were then conducted to summarize the accumulated findings. Methods Genotyping of the selected TRPV1 SNPs was performed using TaqMan real-time PCR in 167 EM and 182 CM participants. Crude and adjusted odds ratios with associated 95% confidence intervals were calculated in the log-additive, dominant, and recessive genetic models. A comprehensive literature search was performed in PubMed, Web of Knowledge, Cochrane Library, and OpenGrey until February 2024. Results In our case-control study, no association was found between TRPV1 SNPs and the risk of migraine chronification, both in the unadjusted logistic regression models and after adjustment for confounding clinical variables. The results of the meta-analysis with a total of 241 participants with EM and 223 with CM confirmed no association between TRPV1 SNPs and the risk of migraine chronification in any of the genetic models tested. Conclusion The results of the present case-control study and meta-analysis exclude a major role of TRPV1 rs8065080, rs222747, and rs222749 as risk factors for migraine chronification. However, further research is needed to investigate the gene-gene and gene-environment interactions of TRPV1 SNPs on the risk of transformation from episodic to chronic migraine.

show abstract

Migraine and gastroesophageal reflux disease: Disentangling the complex connection with depression as a mediator

Shen,

Bian,

Huang

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Objective Gastroesophageal reflux disease (GERD) and migraine are public health concerns worldwide. No observational study has conclusively elucidated the causal relationship between these two conditions. We employed Mendelian randomization (MR) methods to explore the potential causal links between GERD and migraine. Methods Genome-wide association studies were subjected to MR to infer the causality between GERD and migraine. Bidirectional two-sample MR was performed to establish causal relationships. Multivariable MR analysis was conducted to adjust potential confounding factors, and mediation MR analysis was utilized to assess the role of depression between GERD and migraine as a mediator. We primarily utilized the inverse variance weighted method (IVW) and sensitivity analysis methods, including MR-Egger, weighted median, and leave-one-out methods. We assessed heterogeneity and pleiotropy to ensure the reliability of the results. Results Bidirectional two-sample MR revealed a positive causal effect of GERD on migraine (IVW: OR = 1.49, 95% CI: 1.34–1.66, p = 3.70E-13). Migraine did not increase the risk of GERD (IVW: OR = 1.07, 95% CI: 0.98–1.17, p = 0.1139). Multivariable MR indicated that the positive causal effect of GERD on migraine remained after adjustment for factors, such as smoking, alcohol consumption, obesity, type 2 diabetes, and depression. Mediation MR revealed that depression mediated 28.72% of GERD’s effect on migraine. MR analysis was supported by all sensitivity analyses and was replicated and validated in another independent dataset on migraine. Conclusion Our findings elucidate the positive causal effect of GERD on migraine and underscores the mediating role of depression in increasing the risk of migraine due to GERD. Effective control of GERD, particularly interventions targeting depression, may aid in preventing the occurrence of migraine. Future research should delve deeper into the specific pathophysiological mechanisms through which GERD affects migraine risk, facilitating the development of more effective drug targets or disease management strategies.

show abstract

Influences of Genetic and Environmental Factors on Chronic Migraine: A Narrative Review

Cited by 6 publications

References 97 publications

Exploring Headaches in Pediatric Behçet Disease: Prevalence, Clinical Impact, and Management

Exploring Headaches in Pediatric Behçet Disease: Prevalence, Clinical Impact, and Management

Lack of association between TRPV1 gene polymorphisms and risk of migraine chronification: a case-control study and meta-analysis

Migraine and gastroesophageal reflux disease: Disentangling the complex connection with depression as a mediator

Contact Info

Product

Resources

About