Lack of association between TRPV1 gene polymorphisms and risk of migraine chronification: a case-control study and meta-analysis
Martina Giacon,
Sarah Cargnin,
Marta Allena
et al.
Abstract:Objective
To confirm a previously reported association of TRPV1 rs8065080 with the risk of transformation from episodic (EM) to chronic migraine (CM) and to extend knowledge about the role of other TRPV1 single nucleotide polymorphisms (SNPs), we first investigated the impact of three TRPV1 SNPs (rs8065080, rs222747 and rs222749) on the risk of migraine chronification in a case-control study. A systematic review and meta-analysis were then conducted to summarize the accumulated findings.
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