Influence on horse´s pulmonary function using a modified "Open-Lung-Concept"-Ventilation with different oxygen-concentration during general anaesthesia

Schulte-Bahrenberg, Sabine; Hopster, Klaus; Kästner, Sabine; Rohn, Karl; Ohnesorge, Bernhard

doi:10.21836/pem20110318

Cited by 4 publications

(6 citation statements)

References 12 publications

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“…It could be hypothesized that the potential impact of dorsal recumbency on atelectasis and venous admixture development minimizes the benefit of reducing FIO 2 . Similar conclusions were obtained in horses undergoing laparotomy with mechanical ventilationand receiving 0.35, 0.55 or 0.9 FIO 2 (Schulte- Bahrenberg et al 2011). In the present study, the number of horses was targeImpact of low inspired oxygen fraction on oxygenation in clinical horses under general anesthesia O. L. Levionnois et al Pferdeheilkunde 32 (2016) 465 ted at 20 horses per group to detect the effect of FIO 2 .…”

Section: Discussionsupporting

confidence: 80%

“…However, many contributing factors have been identified for the development of peri-anesthetic pulmonary atelectasis in healthy horses, like body weight, thoracic conformation (Mansel andClutton 2008, Moens et al 1995), fasting time, abdominal distension and positioning, or mode of ventilation (Gleed and Dobson 1988). Therefore, the use of intermediate FIO 2 (< 0.5) may not be sufficient to improve the pulmonary mismatch between ventilation and perfusion in horses under clinical conditions (Schulte-Bahrenberg et al 2011). It is also not known if less intra-operative atelectasis could contribute to improve blood oxygenation during recovery (Marntell et al 2005).…”

Section: Introductionmentioning

confidence: 99%

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Impact of low inspired oxygen fraction on oxygenation in clinical horses under general anesthesia

Levionnois¹,

Zuehlke²,

Kuhn³

et al. 2016

PHK

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Summary:The objective was to compare the use of 0.3 and >0.95 oxygen inspired fraction during general anesthesia in horses. Forty client-owned adult horses were anesthetized in dorsal or in lateral recumbency with isoflurane in oxygen and randomly allocated to receive inspiratory fraction of oxygen >0.95 (group HIGH) or 0.3 (group LOW). Mechanical ventilation was provided using pressure controlled mode. Arterial blood gas analysis was performed before, during and after general anesthesia. The group LOW obtained lower intra-operative PaO 2 values but better indices of venous admixture than the group HIGH. The PaO 2 further decreased during the recovery, without significant differences between groups. Even though the use of lower oxygen inspired fraction (0.3) tended to improve pulmonary function during general anesthesia, it markedly decreased safety as a result of hypoxemia. During the recovery, no difference was observed between groups for the arterial oxygenation such that lower intra-anesthetic oxygen inspired fraction did not provide any advantages.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Impact of low inspired oxygen fraction on oxygenation in clinical horses under general anesthesia

Levionnois¹,

Zuehlke²,

Kuhn³

et al. 2016

PHK

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“…Mechanical ventilation for horses in the mOLC group was performed with a predefined PEEP of 10 to 12 cmH 2 O and was not individually titrated for each horse, as recommended in the literature (Agrò and others 2004, Wettstein and others 2006, Papadakos and Lachmann 2007). This simplified method proved to be effective in previous studies (Hopster 2007, Schulte‐Bahrenberg 2008). As an indication of adequate gas exchange in the lung, a p a O 2 of 18.7 kPa was considered to be the lower limit based on the presumption that the p a O 2 increases linearly to the FiO 2 .…”

Section: Discussionmentioning

confidence: 71%

Influence of modified open lung concept ventilation on the cardiovascular and pulmonary function of horses during total intravenous anaesthesia

et al. 2010

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The influence of a modified open lung concept (mOLC) on pulmonary and cardiovascular function during total intravenous anaesthesia (TIVA) in horses was evaluated. Forty-two warmblood horses (American Society of Anesthesiologists class 1 to 2), scheduled for elective surgery (mean [sd] weight 526 [65] kg, age 6.4 [5.4] years) were randomly divided into three groups: ventilation with mOLC, intermittent positive-pressure ventilation (IPPV), and spontaneous breathing. Premedication (0.8 mg/kg xylazine), induction (2.2 mg/kg ketamine and 0.05 mg/kg diazepam) and maintenance of anaesthesia with TIVA (1.4 mg/kg/hour xylazine, 5.6 mg/kg/hour ketamine and 131.1 mg/kg/hour guaifenesin), with inhalation of 35 per cent oxygen in air, were identical in all horses. Heart rate, respiratory rate, mean arterial blood pressure (MAP), pH, and arterial partial pressure of oxygen (p(a)O(2)) and carbon dioxide (p(a)CO(2)) were evaluated. Data were collected every 10 minutes from 20 to 90 minutes anaesthesia time. Factorial analysis of variance and Tukey's post hoc test were used for statistical analysis (a=5 per cent). Horses in the mOLC-ventilated group had an overall significantly higher p(a)O(2) (16.9 [1.0] v 11.7 [1.34] v 10.5 [0.57] kPa) and lower MAP (93.1 [5.47] v 107.1 [6.99] v 101.2 [5.45] mmHg) than the IPPV and spontaneously breathing groups, respectively.

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“…The fraction of inspired oxygen (FiO 2 ) settings during general anaesthesia do not seem to affect recovery quality or the PaO 2 during recovery [340,345,348]. However, horses receiving pulsed delivery of inhaled nitric oxide (NO) during general anaesthesia had better oxygenation and ventilation perfusion (V/Q) matching during recovery [342].…”

Section: Respiratory System In Recoverymentioning

confidence: 99%

“…(1) Intranasal phenylephrine reduces post anesthetic upper airway obstruction in horses [335] (2) An evaluation of apnea or spontaneous ventilation in early recovery following mechanical ventilation in the anesthetized horse [336] (3) Cardiopulmonary effects associated with head-down position in halothane-anesthetized ponies with or without capnoperitoneum [337] (4) High inspired oxygen concentrations increase intrapulmonary shunt in anaesthetized horses [338] (5) Intermittent positive pressure ventilation with constant positive end-expiratory pressure and alveolar recruitment manoeuvre during inhalation anaesthesia in horses undergoing surgery for colic, and its influence on the early recovery period [339] (6) Influence on horse's pulmonary function using a modified "Open-Lung-Concept"-Ventilation with different oxygen-concentration during general anaesthesia [340] (7) Effects of hypercapnic hyperpnea on recovery from isoflurane or sevoflurane anesthesia in horses [341] (8) Oxygenation and plasma endothelin-1 concentrations in healthy horses recovering from isoflurane anaesthesia administered with or without pulse-delivered inhaled nitric oxide [ Table 11. Total of publications giving information about the effects of "other factors" on the recovery phase.…”

mentioning

confidence: 99%

Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature

Gozalo-Marcilla

Ringer

2021

Animals

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Recovery remains the most dangerous phase of general anaesthesia in horses. The objective of this publication was to perform a structured literature review including levels of evidence (LoE) of each study with the keywords “recovery anaesthesia horse”, entered at once, in the search browsers PubMed and Web of Science. The two authors independently evaluated each candidate article. A final list with 444 articles was obtained on 5 April 2021, classified as: 41 “narrative reviews/expert opinions”, 16 “retrospective outcome studies”, 5 “surveys”, 59 “premedication/sedation and induction drugs”, 27 “maintenance with inhalant agents”, 55 “maintenance with total intravenous anaesthesia (TIVA)”, 3 “TIVA versus inhalants”, 56 “maintenance with partial intravenous anaesthesia (PIVA)”, 27 “other drugs used during maintenance”, 18 “drugs before/during recovery”, 18 “recovery systems”, 21 “respiratory system in recovery”, 41 “other factors”, 51 “case series/reports” and 6 “systems to score recoveries”. Of them, 167 were LoE 1, 36 LoE 2, 33 LoE 3, 110 LoE 4, 90 LoE 5 and 8 could not be classified based on the available abstract. This review can be used as an up-to-date compilation of the literature about recovery after general anaesthesia in adult horses that tried to minimise the bias inherent to narrative reviews.

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Influence on horse´s pulmonary function using a modified "Open-Lung-Concept"-Ventilation with different oxygen-concentration during general anaesthesia

Cited by 4 publications

References 12 publications

Impact of low inspired oxygen fraction on oxygenation in clinical horses under general anesthesia

Impact of low inspired oxygen fraction on oxygenation in clinical horses under general anesthesia

Influence of modified open lung concept ventilation on the cardiovascular and pulmonary function of horses during total intravenous anaesthesia

Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature

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