Influence of zolpidem, a novel hypnotic, on the intermediate-stage and paradoxical sleep in the rat

Gottesmann, Claude; Trefouret, Sylvie; Depoortere, H.

doi:10.1016/0091-3057(94)90023-x

Cited by 13 publications

(3 citation statements)

References 4 publications

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“…Zolpidem, a non-benzodiazepine reduces sleep latency and decreases REMS in humans [47]. In animal studies, it has been shown that zolpidem increases slow wave sleep [48] and decreases REMS [49]. GABA B receptors, acting through second messenger systems to modulate potassium and calcium channels, mediate a slow and prolong neuronal activity.…”

Section: Discussionmentioning

confidence: 99%

Gamma-aminobutyric acid (GABA) receptor mediates suanzaorentang, a traditional Chinese herb remedy, -induced sleep alteration

Tsai

Chen

et al. 2006

J Biomed Sci

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The sedative-hypnotic medications, including benzodiazepines and non-benzodiazepines, are the most common treatments for insomnia. However, concerns regarding patterns of inappropriate use, dependence and adverse effects have led to caution in prescribing those sedative-hypnotic medications. On the other hand, a traditional Chinese herb remedy, suanzaorentang, has been efficiently and widely used in clinic for insomnia relief without severe side effects in Asia. Although suanzaorentang has been reported to improve sleep disruption in insomniac patients, its mechanism is still unclear. The present study was designed to elucidate the effects of oral administration of suanzaorentang on physiological sleep-wake architectures and its underlying mechanism in rats. We found that oral administration of suanzaorentang at the beginning of the dark onset dose-dependently increased non-rapid eye movement sleep (NREMS) during the dark period, but had no significant effect on rapid eye movement sleep (REMS). Our results also indicated that intracerebroventricular (ICV) administration of gamma-aminobutyric acid (GABA) receptor type A antagonist, bicuculline, significantly blocked suanzaorentang-induced enhancement in NREMS during the dark period, but GABA(B) receptor antagonist, 2-hydroxysaclofen had no effect. These results implicated that this traditional Chinese herb remedy, suanzaorentang increases spontaneous sleep activity and its effects may be mediated through the GABA(A) receptors, but not GABA(B) receptors.

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Section: Discussionmentioning

confidence: 99%

Gamma-aminobutyric acid (GABA) receptor mediates suanzaorentang, a traditional Chinese herb remedy, -induced sleep alteration

Tsai

Chen

et al. 2006

J Biomed Sci

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“…In the cat also, the IS substitutes for PS under barbiturates ( Gottesmann et al 1984 ). More recently, we studied the IS and PS evolution under benzodiazepines (BDZs), second‐generation hypnotics ( Gandolfo et al 1994 ) and under zolpidem ( Gottesmann et al 1994 ) and zopiclone ( Gauthier et al 1997 ), a new generation of hypnotics.…”

Section: Introductionmentioning

confidence: 99%

The intermediate stage and paradoxical sleep in the rat: influence of three generations of hypnotics

Gottesmann

Gandolfo

Arnaud

et al. 1998

Eur J of Neuroscience

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Paradoxical sleep in the rat, cat and mouse is preceded and sometimes followed by a short-lasting intermediate stage characterized by high-amplitude anterior cortex spindles and low-frequency hippocampal theta rhythm. Several neurophysiological arguments suggest that the intermediate stage corresponds to a brief functional disconnection of the forebrain from the brainstem. This paper is devoted to the review of quantitative and qualitative influences of three generations of hypnotics on the intermediate stage-paradoxical sleep couple. Barbiturates, first-generation hypnotics, extend the intermediate stage at the expense of paradoxical sleep. Three benzodiazepines are compared, two with a short half-life (triazolam and midazolam) and one with a long half-life (diazepam). They also decrease sleep occurrence latency and increase the intermediate stage at the expense of paradoxical sleep, except for midazolam, which increases both the intermediate stage and paradoxical sleep at low dose. Zolpidem and zopiclone, hypnotics of third generation, decrease paradoxical sleep but the intermediate stage never substitutes for paradoxical sleep. The results are discussed in relationship to the functional aspects of this turning-point period of sleep.

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“…IS has been described as occupying approximately 1% of the circadian cycle, while occurring 75% of the time prior to and 15% after paradoxical sleep (PS), and having a characteristic spindle pattern in the electrocorticogram (ECoG) (Terrier and Gottesmann, 1978). Studies have included the introduction of benzodiazepines (BZD) to help identify the neurophysiological mechanisms involved in the maintenance of the thalamocortical spindle oscillations that define IS (Gandolfo et al, 1994;Gottesmann et al, 1994). These studies demonstrate that IS sleep is a measurable sleep stage that is maintained by the hyperpolarization of GABA A containing thalamocortical neurons.…”

Section: Introductionmentioning

confidence: 99%

An evaluation of the use of seizure prone rats when investigating intermediate stage sleep

Morrissey

Anch

Duntley

2005

Journal of Neuroscience Methods

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Influence of zolpidem, a novel hypnotic, on the intermediate-stage and paradoxical sleep in the rat

Cited by 13 publications

References 4 publications

Gamma-aminobutyric acid (GABA) receptor mediates suanzaorentang, a traditional Chinese herb remedy, -induced sleep alteration

Gamma-aminobutyric acid (GABA) receptor mediates suanzaorentang, a traditional Chinese herb remedy, -induced sleep alteration

The intermediate stage and paradoxical sleep in the rat: influence of three generations of hypnotics

An evaluation of the use of seizure prone rats when investigating intermediate stage sleep

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