Influence of Water-Soluble Polymers on the Dissolution of Nifedipine Solid Dispersions with Combined Carriers.

Suzuki, Hideshi; Sunada, Hisakazu

doi:10.1248/cpb.46.482

Cited by 116 publications

(47 citation statements)

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“…Recently, combined carriers have been used and a higher increase in drug dissolution was reported. 6,7 However, those reported solid dispersions were still a very low percentage of drugs loading in the system, which required an extremely high amount of carrier. High drug-loaded solid dispersion with high drug dissolution enhancement is not an easy task since the drug presented in such a system is in complete crystal has high crystallinity.…”

Section: Introductionmentioning

confidence: 99%

Dissolution improvement of high drug-loaded solid dispersion

Okonogi¹,

Puttipipatkhachorn

2006

AAPS PharmSciTech

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This study focused on an investigation of a high drugloaded solid dispersion system consisting of drug, carrier, and surfactant. Solid dispersions of a water-insoluble ofloxacin (OFX) with polyethylene glycol (PEG) of different molecular weights, namely binary solid dispersion systems, were prepared at drug to carrier not less than 5:5. Polysorbate 80, a nonionic surfactant, was incorporated into the binary solid dispersion systems as the third component to obtain the ternary solid dispersion systems. The powder x-ray diffraction and differential scanning calorimetric studies indicated that crystalline OFX existed in the solid dispersions with high drug loading. However, a decreased crystallinity of the solid dispersions obtained revealed that a portion of OFX was in an amorphous state. The results indicated a remarkably improved dissolution of drug from the ternary solid dispersion systems when compared with the binary solid dispersion systems. This was because of polysorbate 80, which improved wettability and solubilized the non-molecularly dispersed or crystalline fraction of OFX.

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Section: Introductionmentioning

confidence: 99%

Dissolution improvement of high drug-loaded solid dispersion

Okonogi¹,

Puttipipatkhachorn

2006

AAPS PharmSciTech

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“…In this study, the selected stabilizers including partially hydrolyzed PVA which has been shown to increase drug concentration in vivo (Suzuki and Sunada 1998 ) , P407 which has been shown to alter surface properties of crystals, and SDS which is a nonpolymeric anionic surfactant. SDS may be used to facilitate wetting and dissolution rates.…”

Section: Resultsmentioning

confidence: 99%

Pharmaceutical Cryogenic Technologies

Yang¹,

Owens²,

Williams

2011

Formulating Poorly Water Soluble Drugs

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Poor bioavailability associated with poorly water-soluble compounds remains a challenging issue in drug development. Particle engineering may be used to improve the physicochemical properties of poorly water-soluble compounds, thereby enhancing the bioavailability. Cryogenic technologies, including spray freeze drying (SFD), spray freezing into liquid (SFL), and thin fi lm freezing (TFF), are "bottom-up" precipitation processes to generate amorphous nanostructured aggregates with signifi cantly enlarged surface area, higher dissolution rates, and supersaturation, via rapidly inducing nucleation followed by particle growth arrest through stabilization via polymers and solidifi cation of the solvent. This chapter provides detailed description of each cryogenic process, formulation guidelines, and characterization analyses. Finally, examples of cryogenically engineered drug compositions with improved in vitro and in vivo macroscopic performance are provided to illustrate the potential benefi ts of cryogenic technologies, especially TFF.

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“…The commons side effect is nausea and the less common side effects are vomiting and cramp [106]. On the other hand, solid dispersion, in which compounds are dispersed into water-soluble carriers, has been generally used to improve the dissolution properties and the bioavailability of drugs that are poorly soluble in water [107][108][109][110][111]. MC has the hydroxyl group in a structure and is interactive with the carboxylic acid of carboxyvinyl polymer (CP), as well as poly(ethylene oxide) (PEO).…”

Section: Methylcellulosementioning

confidence: 99%

Pharmaceutical significance of cellulose: A review

Kamel¹,

Ali²,

Jahangir³

et al. 2008

Express Polym. Lett.

375

191

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Abstract. The amalgamation of polymer and pharmaceutical sciences led to the introduction of polymer in the design and development of drug delivery systems. Polymeric delivery systems are mainly intended to achieve controlled or sustained drug delivery. Polysaccharides fabricated into hydrophilic matrices remain popular biomaterials for controlled-release dosage forms and the most abundant naturally occurring biopolymer is cellulose; so hdroxypropylmethyl cellulose, hydroxypropyl cellulose, microcrystalline cellulose and hydroxyethyl cellulose can be used for production of time controlled delivery systems. Additionally microcrystalline cellulose, sodium carboxymethyl cellulose, hydroxypropylmethyl cellulose, hydroxyethyl cellulose as well as hydroxypropyl cellulose are used to coat tablets. Cellulose acetate phthalate and hydroxymethyl cellulose phthalate are also used for enteric coating of tablets. Targeting of drugs to the colon following oral administration has also been accomplished by using polysaccharides such as hdroxypropylmethyl cellulose and hydroxypropyl cellulose in hydrated form; also they act as binders that swell when hydrated by gastric media and delay absorption. This paper assembles the current knowledge on the structure and chemistry of cellulose, and in the development of innovative cellulose esters and ethers for pharmaceuticals.

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Influence of Water-Soluble Polymers on the Dissolution of Nifedipine Solid Dispersions with Combined Carriers.

Cited by 116 publications

References 0 publications

Dissolution improvement of high drug-loaded solid dispersion

Dissolution improvement of high drug-loaded solid dispersion

Pharmaceutical Cryogenic Technologies

Pharmaceutical significance of cellulose: A review

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