Influence of Volatile Anaesthetics on Lung Cells and Lung Surfactant

Stephanova, E.; Valtcheva-Sarker, R.; Topouzova-Hristova, Tanya; Lalchev, Zdravko

doi:10.1080/13102818.2007.10817481

Cited by 8 publications

(5 citation statements)

References 57 publications

(54 reference statements)

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“…The mean layer thickness of the e-cigarette liquids on the lung epithelium was compared with the thickness of the surfactant film that covers both the alveolar and the bronchial regions. This is meaningful information because the lung surfactant is the first barrier encountered by inhaled noxious agents, and its damage leads to severe respiratory problems (Hamm et al, 1996;Hohlfeld et al, 1997;Stephanova et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Aerosol deposition doses in the human respiratory tree of electronic cigarette smokers

Manigrasso

Buonanno

Fuoco

et al. 2015

Environmental Pollution

121

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Section: Introductionmentioning

confidence: 99%

Aerosol deposition doses in the human respiratory tree of electronic cigarette smokers

Manigrasso

Buonanno

Fuoco

et al. 2015

Environmental Pollution

121

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“…Lung surfactant, located between the alveolar lumen and the epithelial cell membranes, is the first barrier to any toxic agents that may penetrate into the respiratory system. [ 18 ] Sevoflurane may reduce cooperative interactions among phospholipids in the lung surfactant monolayer. Moreover, fluidification of the condensed phases promoted by sevoflurane could potentially impair the ability of surfactant films to sustain the lowest surface tension.…”

Section: Discussionmentioning

confidence: 99%

Negative-pressure-related diffuse alveolar hemorrhage after monitored anesthesia care for vertebroplasty: a case report

Hwang²,

Lee

et al. 2021

J Med Case Reports

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Background Diffuse alveolar hemorrhage (DAH) is a rare, life-threatening condition that can present as a spectrum of nonspecific symptoms, ranging from cough, dyspnea, and hemoptysis to severe hypoxemic respiratory failure. Perioperative DAH is frequently caused by negative pressure pulmonary edema resulting from acute airway obstruction, such as laryngospasm, although hemorrhage itself is rare. Case presentation This case report describes an unexpected hemoptysis following monitored anesthesia care for vertebroplasty. A 68-year-old Asian woman, with a compression fracture of the third lumbar vertebra was admitted for vertebroplasty. There were no noticeable events during the procedure. After the procedure, the patient was transferred to the postanesthesia care unit (PACU), at which sudden hemoptysis occurred. The suspected airway obstruction may have developed during transfer or immediate arrive in PACU. In postoperative chest x-ray, newly formed perihilar consolidation observed in both lung fields. The patients was transferred to a tertiary medical institution for further evaluation. She diagnosed with DAH for hemoptysis, new pulmonary infiltrates on chest x-ray and anemia. The patient received supportive care and discharged without further events. Conclusions Short duration of airway obstruction may cause DAH, it should be considered in the differential diagnosis of postoperative hemoptysis of unknown etiology.

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“…23 Furthermore, inhaled anesthetic agents are associated with a reduction in surface tension lowering capacity and exert damage on surfactant-producing alveolar epithelial cells. 24 These variations in the use of anesthetic and surgical techniques would be difficult to control for, but future studies designed to compare standardized surgical and anesthetic protocols are required in order to adequately elucidate the individual contributions of each of these factors.…”

Section: Discussionmentioning

confidence: 99%