Influence of vitamin E and selenium supplement on antibody production in horses

Baalsrud, Karen J.; Øvernes, Gunnar

doi:10.1111/j.2042-3306.1986.tb03694.x

Cited by 41 publications

(16 citation statements)

References 12 publications

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“…This may relate to the longer period of time that the LS horses had received a low-Se diet at the time of this vaccine challenge (approximately 14 mo when aeeounting for initial depletion phase), compared with the previously reported study where the vaccine challenge was administered after 7 mo on the low-Se diet (Brummer et al, 2011). This may indicate an adaptation to the lower dietary Se intake, possibly through eompensation by other eomponents of the antioxidant system, such as vitamin E. Similar to the eurrent study, Baalsrud and Ovemes (1986) reported comparable antibody production in response to vaccination between horses on a Se-supplemented (0.5 mg Se/kg DM) or a low-Se and low-vitamin E control diet (0.03 mg Se/kg DM, 18 mg a-tocopheryl acetate/kg DM). However, horses receiving a combination of Se and vitamin E supplementation (0.5 mg/kg DM, 80 mg a-tocopheryl acetate/kg DM) reportedly had improved antibody production compared with the low-Se and vitamin E control group (Baalsrud and Ovemes, 1986).…”

Section: Discussionsupporting

confidence: 51%

“…This may indicate an adaptation to the lower dietary Se intake, possibly through eompensation by other eomponents of the antioxidant system, such as vitamin E. Similar to the eurrent study, Baalsrud and Ovemes (1986) reported comparable antibody production in response to vaccination between horses on a Se-supplemented (0.5 mg Se/kg DM) or a low-Se and low-vitamin E control diet (0.03 mg Se/kg DM, 18 mg a-tocopheryl acetate/kg DM). However, horses receiving a combination of Se and vitamin E supplementation (0.5 mg/kg DM, 80 mg a-tocopheryl acetate/kg DM) reportedly had improved antibody production compared with the low-Se and vitamin E control group (Baalsrud and Ovemes, 1986). Therefore, it is plausible that the adequate vitamin E status of our horses allowed for a normal antibody response to vaccination, even in the horses of low Se status.…”

Section: Discussionmentioning

confidence: 59%

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The effect of selenium supplementation on vaccination response and immune function in adult horses1

Brummer

Hayes

Adams

et al. 2013

Journal of Animal Science

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Selenium status has been reported to affect immune function across many different species. Yet few studies have focused on the effect of Se status on the equine immune system. This study examined the effect of Se supplementation on vaccination response and immune function in mature horses. Twenty-eight horses were blocked by age and sex and were randomly allocated to 1 of 4 dietary treatment groups: low Se (LS), adequate Se (AS), Se-yeast (SP), and sodium selenite (SS). For 35 wk, horses allocated to LS, SP, and SS received a low-Se diet (0.06 mg/kg DM) with the intention to lower Se stores, whereas AS received an adequate Se diet (0.12 mg/kg DM). A 29-wk repletion phase was as follows: LS and AS were kept on the diets fed during the depletion period, whereas SP and SS received the depletion diet plus their respective Se supplements to achieve a dietary Se concentration of 0.3 mg/kg DM. The Se status of the horses was monitored using whole blood Se and glutathione peroxidase (GSH-Px) activity as indicators. At wk 22 and 25 of the repletion phase, horses were vaccinated intramuscularly with 10 mg ovalbumin (OVA). Horses were also vaccinated against equine influenza at wk 25. Blood samples were collected for 7 wk after initial vaccination for serum separation and at 0, 3, and 5 wk postvaccination for peripheral blood mononuclear cell (PBMC) isolation and whole blood cytokine mRNA evaluation. At wk 22 of the repletion phase, both Se and GSH-Px were greater for SP and SS compared with AS and LS (P < 0.001). Serum vitamin E was similar between treatments. Response to OVA vaccination, evaluated as OVA-specific IgG production, cytokine mRNA expression of PBMC stimulated with OVA in vitro, and lymphocyte proliferation, was unaffected by Se status. Similarly, memory response to the influenza vaccine was not affected by Se status. However, decreased mRNA expression of selected cytokines was observed in PBMC stimulated with phorbol 12-myristate 13-acetate for LS compared with AS, SP, and SS (P < 0.05). Whole blood mRNA expression of IL-10 was greater for SS compared with LS, AS, and SP (P = 0.043). Although the OVA and influenza vaccination responses were unaffected by Se status, other measures of immune function did indicate that low Se status could adversely affect cell-mediated immunity.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 59%

The effect of selenium supplementation on vaccination response and immune function in adult horses1

Brummer

Hayes

Adams

et al. 2013

Journal of Animal Science

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“…at most, 42 iu/kg DM. However, higher concentrations !ly different, P c 0.05 may be required to ensure immunocompetence (Baalsrud and Overnes 1986;NRC 1989).…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamin E status on lipid peroxidation in exercised horses

McMeniman

Hintz

1992

Equine Veterinary Journal

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“…In horses fed diets low in vitamin E and selenium, the role of α‐tocopherol in the humoral immune response was demonstrated by vaccination against tetanus toxoid and equine influenza virus . An increased IgG response occurred in horses receiving either vitamin E or vitamin E and selenium.…”

Section: Chemical Structure and Propertiesmentioning

confidence: 99%

A Comparative Review of Vitamin E and Associated Equine Disorders

Finno

Valberg

2012

Veterinary Internal Medicne

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Vitamin E is a primary chain-breaking antioxidant that prevents cyclic propagation of lipid peroxidation. Across species, vitamin E is essential for normal neuromuscular function by acting as a potent antioxidant, as well as by modulating the expression of certain genes, inhibiting platelet aggregation and stabilizing plasma membranes. This review focuses on vitamin E structure, absorption, metabolism, current equine dietary recommendations, the interplay between antioxidants and exercise, a discussion of the necessity of vitamin E supplementation in the horse above the Nutritional Research Council (NRC) 2007 requirements, and a review of equine diseases that are associated with a vitamin E deficiency. Particular emphasis is placed on the proteins involved in vitamin E absorption, transport, and metabolism as potential candidates for vitamin E-associated diseases across species.

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Influence of vitamin E and selenium supplement on antibody production in horses

Cited by 41 publications

References 12 publications

The effect of selenium supplementation on vaccination response and immune function in adult horses1

The effect of selenium supplementation on vaccination response and immune function in adult horses1

Effect of vitamin E status on lipid peroxidation in exercised horses

A Comparative Review of Vitamin E and Associated Equine Disorders

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