Influence of vitamin C on the elicitation of allergic contact dermatitis to <i>p</i>‐phenylenediamine

Basketter, David A.; White, Ian R.; Kullavanijaya, Preya; Tresukosol, Poohglin; Wichaidit, Mingkwan; McFadden, John

doi:10.1111/cod.12576

Cited by 19 publications

(15 citation statements)

References 15 publications

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“…This is directly related to its co-factor activity for the synthesis of collagen, with impaired wound healing an early indicator of hypovitaminosis C [ 68 , 168 ]. Vitamin C turnover at wound sites, due to both local inflammation and the demands of increased collagen production, means that supplementation is useful, and both topical application and increased nutrient intake have been shown to be beneficial [ 166 , 169 , 170 ]. Supplementation with both vitamin C and vitamin E improved the rate of wound healing in children with extensive burns [ 171 ], and plasma vitamin C levels in smokers, abstaining smokers and non-smokers were positively associated with the rate of wound healing [ 162 ].…”

Section: Challenges To the Maintenance Of Skin Health And Potentiamentioning

confidence: 99%

The Roles of Vitamin C in Skin Health

2017

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The primary function of the skin is to act as a barrier against insults from the environment, and its unique structure reflects this. The skin is composed of two layers: the epidermal outer layer is highly cellular and provides the barrier function, and the inner dermal layer ensures strength and elasticity and gives nutritional support to the epidermis. Normal skin contains high concentrations of vitamin C, which supports important and well-known functions, stimulating collagen synthesis and assisting in antioxidant protection against UV-induced photodamage. This knowledge is often used as a rationale for the addition of vitamin C to topical applications, but the efficacy of such treatment, as opposed to optimising dietary vitamin C intake, is poorly understood. This review discusses the potential roles for vitamin C in skin health and summarises the in vitro and in vivo research to date. We compare the efficacy of nutritional intake of vitamin C versus topical application, identify the areas where lack of evidence limits our understanding of the potential benefits of vitamin C on skin health, and suggest which skin properties are most likely to benefit from improved nutritional vitamin C intake.

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Section: Challenges To the Maintenance Of Skin Health And Potentiamentioning

confidence: 99%

The Roles of Vitamin C in Skin Health

2017

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“…In view of the fact that many consumers, including those sensitised, prefer to nevertheless dye their hair (even if expecting symptoms of ACD after doing so [ 161 ]), alternative preventive strategies are being developed. One approach is to protect the surrounding glabrous skin by the application of a topical antioxidant (ascorbic acid) prior to hair dyeing, as has been quite successfully tried in 2 proof-of-principle studies [ 162 , 163 ]. The other approach is the development of presumably less-sensitising derivatives of e.g., p -phenylenediamine (PPD).…”

Section: Resultsmentioning

confidence: 99%

Contact Allergy: A Review of Current Problems from a Clinical Perspective

Uter

Werfel

White

et al. 2018

IJERPH

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Contact allergy is common, affecting 27% of the general population in Europe. Original publications, including case reports, published since 2016 (inclusive) were identified with the aim of collating a full review of current problems in the field. To this end, a literature search employing methods of systematic reviewing was performed in the Medline® and Web of Science™ databases on 28 January 2018, using the search terms (“contact sensitization” or “contact allergy”). Of 446 non-duplicate publications identified by above search, 147 were excluded based on scrutiny of title, abstract and key words. Of the remaining 299 examined in full text, 291 were deemed appropriate for inclusion, and main findings were summarised in topic sections. In conclusion, diverse sources of exposures to chemicals of widely-differing types and structures, continue to induce sensitisation in man and may result in allergic contact dermatitis. Many of the chemicals are “evergreen” but others are “newcomers”. Vigilance and proper investigation (patch testing) are required to detect and inform of the presence of these haptens to which our populations remain exposed.

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“…Vitamin C can also reduce allergies often encountered in dermatology. A case report concluded that it reduced the allergic contact dermatitis caused by hair dyes ( Basketter et al, 2016 ). The main component of hair dye is p -phenylenediamine.…”

Section: Vitamin C-related Skin Diseasesmentioning

confidence: 99%

Role of Vitamin C in Skin Diseases

Wang

Jiang

et al. 2018

Front. Physiol.

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Vitamin C (ascorbic acid) plays an important role in maintaining skin health and can promote the differentiation of keratinocytes and decrease melanin synthesis, leading to antioxidant protection against UV-induced photodamage. Normal skin needs high concentrations of vitamin C, which plays many roles in the skin, including the formation of the skin barrier and collagen in the dermis, the ability to counteract skin oxidation, and the modulation of cell signal pathways of cell growth and differentiation. However, vitamin C deficiency can cause or aggravate the occurrence and development of some skin diseases, such as atopic dermatitis (AD) and porphyria cutanea tarda (PCT). Levels of vitamin C in plasma are decreased in AD, and vitamin C deficiency may be one of the factors that contributes to the pathogenesis of PCT. On the other hand, high doses of vitamin C have significantly reduced cancer cell viability, as well as invasiveness, and induced apoptosis in human malignant melanoma. In this review, we will summarize the effects of vitamin C on four skin diseases (porphyria cutanea tarda, atopic dermatitis, malignant melanoma, and herpes zoster and postherpetic neuralgia) and highlight the potential of vitamin C as a therapeutic strategy to treat these diseases, emphasizing the clinical application of vitamin C as an adjuvant for drugs or physical therapy in other skin diseases.

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Influence of vitamin C on the elicitation of allergic contact dermatitis to p‐phenylenediamine

Abstract: The results suggest that treatment of the skin adjacent to the hair-bearing area with antioxidant could form part of a strategy to reduce the burden of cosmetic allergic contact dermatitis caused by hair dyeing.

Cited by 19 publications

References 15 publications

The Roles of Vitamin C in Skin Health

The Roles of Vitamin C in Skin Health

Contact Allergy: A Review of Current Problems from a Clinical Perspective

Role of Vitamin C in Skin Diseases

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