Influence of vitamin C on bisphenol A, nonylphenol and octylphenol induced oxidative damages in liver of male rats

Korkmaz, Ali; Ahbab, Müfide Aydoğan; Kolankaya, Dürdane; Barlas, Nurhayat

doi:10.1016/j.fct.2010.07.019

Cited by 149 publications

(126 citation statements)

References 48 publications

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“…In addition, co-administration of vitamin C did not reverse the decreased GSH content in the hepatocytes. In accordance with our results, Korkmaz et al [25] reported that vitamin C co-administration along with BPA aggravated oxidative damage in the liver of male rats. Such an effect of vitamin C in this study might be due to its prooxidant impact, where vitamin C converts Fe 3+ into Fe 2+ , which reacts with oxygen and hydrogen peroxide resulting in formation of hydroxyl radicals and superoxide anions [25,36].…”

Section: Discussionsupporting

confidence: 82%

“…In accordance with our results, Korkmaz et al [25] reported that vitamin C co-administration along with BPA aggravated oxidative damage in the liver of male rats. Such an effect of vitamin C in this study might be due to its prooxidant impact, where vitamin C converts Fe 3+ into Fe 2+ , which reacts with oxygen and hydrogen peroxide resulting in formation of hydroxyl radicals and superoxide anions [25,36]. Supporting our results, Sakagami and Satoh [37] also reported that the addition of ascorbic acid to the culture medium increased dose-dependently the oxidation potential and acted as a prooxidant for the induction of apoptotic cell death.…”

Section: Discussionsupporting

confidence: 82%

“…On the other hand, utilization of GSH by GST and GPx might cause such decreases in the GSH pool [1]. Similar to our findings, it has been reported that BPA leads to decreased GSH levels [25].…”

Section: Discussionsupporting

confidence: 81%

“…Similar to our results, the increase in the MDA content in the tissues were not observed in mice, which were intraperitoneally injected with BPA (25 and 50 mg/kg/day for 5 days) despite a marked increase of ROS production [21]. On the other hand, in other studies, BPA has been reported to cause significant increases in lipid peroxidation in the liver of male rats orally exposed to BPA at doses of 0.2, 2.0, and 20 µg/kg/day for 30 days [5] and 25 mg/kg/ day for 50 days [25]. The findings obtained in mammalian studies led us to conclude that the effect of BPA on lipid peroxidation might be changed depending on the experimental design and duration.…”

Section: Discussionmentioning

confidence: 94%

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Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Kaya¹,

Kaptaner²

2016

Acta Biologica Hungarica

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In this study, isolated hepatocytes of pearl mullet (Alburnus tarichi) were exposed to bisphenol A (BPA) at concentrations of 25, 50, 100, and 200 µM for 24 h. Moreover, an in vitro antioxidant concentration of vitamin C (50 µM) was administrated to the culture medium along with the BPA exposures. Next, the antioxidant defense system parameters were analyzed. According to the results, the highest concentration of BPA (200 µM) proved to be severely toxic for the cells. The increased activities of superoxide dismutase (SOD) and glutathione-S-transferase (GST), the fluctuated activities of glutathione peroxidase (GPx), and the decreased content of reduced glutathione (GSH) were compared to the control group after the BPA exposures. Vitamin C co-administration was found to cause further increases in the SOD, GPx, and GST activities in some of the experimental groups and vitamin C could not restore the GSH content. Malondialdehyde (MDA) levels were observed to be unaffected in all exposure groups. These results show that BPA causes alterations in the antioxidant defenses of the isolated fish hepatocytes. In addition, vitamin C co-administration along with BPA was found to be non-protective against BPA-induced oxidative stress, consequently, aggravated a negative BPA impact.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 94%

See 2 more Smart Citations

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Kaya¹,

Kaptaner²

2016

Acta Biologica Hungarica

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“…BPA can also induce free radical generation with oxidative stress, thereby reducing epididymal or testicular sperm counts, and increasing DNA damage and cell apoptosis. This has been considered an important factor in testicular structural damage and dysfunction [Anjum et al 2011;Korkmaz et al 2010;Li et al 2009;Meeker et al 2010].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Cordyceps militaris extract against bisphenol A induced reproductive damage

Wang

Chen

Jiang

et al. 2016

Systems Biology in Reproductive Medicine

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4‐tert‐Octylphenol [MAK Value Documentation in German language, 2016]

Hartwig

2016

The MAK‐Collection for Occupational Health and Safety

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4‐tert‐Octylphenol The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated 4‐tert‐octylphenol to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints with the exception of developmental toxicity. Available unpublished study reports and publications are described in detail. 4‐tert‐Octylphenol is an endocrine‐active substance that might impair fertility. Despite appropriate investigations, no such effects and no influence on fertility were seen in a two‐generation feeding study in rats after doses of up to 250 mg/kg bw. In this study and in a 90‐day study, the most sensitive effect is delayed body weight development with NOAEL and LOAEL of 15 and 20 mg/kg bw and day, respectively. In a Draize test, 4‐tert‐octylphenol is a severe eye irritant. Because there are no inhalation studies investigating possibly irritating effects on the airways, bisphenol A, which is also a strong eye irritant, is used as a read‐across and a MAK value of 0.5 ml 4‐tert‐octylphenol/m 3 (4 mg/m 3 ) is thus established. The dose taken up at this concentration is clearly below the equipotent dose for 4‐tert‐octylphenol calculated from the human LOAEL for ethinylestradiol and 17β‐estradiol. Since the critical effect of 4‐tert‐octylphenol is local, Peak Limitation Category I is assigned. In analogy to bisphenol A, an excursion factor of 1 has been set. The substance is not genotoxic. Skin contact is not expected to lead to systemic toxicity or contact sensitization.

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Influence of vitamin C on bisphenol A, nonylphenol and octylphenol induced oxidative damages in liver of male rats

Cited by 149 publications

References 48 publications

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Protective effect of Cordyceps militaris extract against bisphenol A induced reproductive damage

4‐tert‐Octylphenol [MAK Value Documentation in German language, 2016]

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