Protective effect of <i>Cordyceps militaris</i> extract against bisphenol A induced reproductive damage

Wang, Jian; Chen, Chen; Jiang, Zhihui; Wang, Meng; Jiang, Hai; Zhang, Xiaoying

doi:10.1080/19396368.2016.1182234

Cited by 41 publications

(44 citation statements)

References 37 publications

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“…Among these natural active compounds, cordycepin has been proved to be an important immunomodulatory active compound which affects the actions of immune cells and cytokine network, it could protect against ischemia–reperfusion‐induced testicular injury. Cordycepin inhibits melanoma cell growth in mice with no adverse effects (Okur et al, ; Wang et al, ; Yoshikawa et al, ; Zhou et al, ). CMP could effectively improve the immune function through protection against oxidative stress, and even could have stronger abilities of hypoglycemic effects than Cordyceps sinensis polysaccharide (Liu et al, ; Zhang et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effects of superfine grinding on the properties and qualities of Cordyceps militaris and its spent substrate

Shi

Zhang

Bhandari

et al. 2019

J Food Process Preserv

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The main purpose of this study is to study the effect of superfine grinding (SG) technology on the physicochemical properties of Cordyceps militaris (CM) and its spent substrate (SS). The results showed that the particle size of the sample powder decreased significantly under the SG treatment and reached below 15 μm finally. With the decrease in particle size, the surface tension of materials decreased and water‐holding capacity (WHC) of aqueous solution of CM and its SS powder decreased by 58.72% and 48.36%, while the water soluble index (WSI) increased to 0.73 and 0.44 g/g, respectively, also the hygroscopic property, L* value and DPPH radical scavenging capacity increased significantly. In addition, the cordycepin yield of two materials increased by 9.49% and 14.61% for 4 hr SG treatment, respectively. The results showed that the SG technology could effectively improve the physicochemical properties of CM powder and the extraction of its effective components, in addition, a new idea was opened up for the effective utilization of waste materials such as edible and medicinal fungi culture medium. Practical applicationsThis study investigated the effect of superfine grinding treatments on the physicochemical properties of the powder of Cordyceps militaris (CM) and its spent substrate (SS). The results shows the advances of superfine grinding on the particle size, surface tension, water hydration capacity, color, antioxidant capacity, and the yield of active component. And it could realize the maximum utilization of resources like medical plants and the reutilization of the waste during herb culturing, when treatments like superfine grinding was applied.

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Section: Introductionmentioning

confidence: 99%

Effects of superfine grinding on the properties and qualities of Cordyceps militaris and its spent substrate

Shi

Zhang

Bhandari

et al. 2019

J Food Process Preserv

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“…Meanwhile, Cordyceps militaris improved redox properties of CKD patients by affecting serum levels of Cys-C, MPO, NO, SOD, and MDA (Table 4, P < 0.05). The antioxidant properties of Cordyceps militaris were reported in the animal models with reproductive damage induced by bisphenol A by improving the SOD level and reducing the MDA level [52]. Comparatively, ascorbic acid has been well known to have strong antioxidant properties while a previous report showed that a significant protective effect of ascorbic acid was not observed and could not affect peak postoperative serum creatinine and the lowest postoperative creatinine clearance on the incidence of postoperative acute renal injury either [53].…”

Section: Discussionmentioning

confidence: 99%

Cordyceps militarisImproves Chronic Kidney Disease by Affecting TLR4/NF-κB Redox Signaling Pathway

Sun

Dong

Jiang

et al. 2019

Oxidative Medicine and Cellular Longevity

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Cordyceps militaris may show good promise in protecting against chronic kidney disease (CKD) but the molecular mechanism remains unclear. CKD risk is associated with the Toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB) signaling pathway. Cordycepin is the main component of Cordyceps militaris and may affect the TLR4/NF-κB pathway. Cordycepin was prepared by preparative HPLC. CKD patients were assigned into Cordyceps militaris (COG, 100 mg daily) and placebo (CG) groups. Cordycepin activity was measured using human embryo kidney cells (HEK293T). Biochemical indices, the levels of TLR4, NF-κB, cyclooxygenase-2 (COX2), tumor necrosis factor-alpha (TNF-α), and interleukin-1 beta (IL-1β), were measured by real-time qRT-PCR, or ELISA kits and or Western blot. After 3-month treatment, cordycepin reduced the levels of urinal protein, blood urea nitrogen (BUN), and creatinine by 36.7%±8.6%, 12.5%±3.2%, and 18.3%±6.6%, respectively (P<0.05). Cordyceps militaris improved lipid profile and redox capacity of CKD patients by reducing the serum levels of TG, TC, and LDL-C by 12.8%±3.6%, 15.7%±4.1%, and 16.5%±4.4% and increasing the HDL-C level by 10.1%±1.4% in the COG group when compared with the CG group, respectively (P<0.05). The serum levels of cystatin-C (Cys-C), myeloperoxidase (MPO), and malondialdehyde (MDA) were reduced by 14.0%±3.8%, 26.9%±12.3%, and 19.7%±7.9% while nitric oxide (NO) and superoxide dismutase (SOD) were increased by 12.5%±2.9% and 25.3%±13.4% in the COG group when compared with the CG group, respectively (P<0.05). Cordycepin reduced the levels of TLR4, NF-κB, COX2, TNF-α, and IL-1β in HEK293T cells too (P<0.05). However, cordycepin could not affect the levels anymore if TLR4 was silenced. Cordyceps militaris protected against CKD progression by affecting the TLR4/NF-κB lipid and redox signaling pathway via cordycepin.

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“…Rats were administered BPA via gavage at 10 mg/kg/day BPA for 14 days, and it lowered T levels and decreased testis weight and inhibited antioxidants (such as SOD2 and catalase) and co-treatment with an antioxidant (lipoic acid) was able to reverse it ( 112 ). Male adult rats were administrated via gavage of 200 mg/kg BPA for 4 weeks, and it inhibited serum LH and T levels after decreasing SOD, GPx, and GSH and increasing ROS generation and antioxidants can attenuate BPA-induced inhibition ( 113 ). Adult male Wistar albino rats (aged 3 months) were gavaged with 50, 500, and 1,000 μg/kg BPA and/or vitamin E (40 mg/kg) for 3 months, and BPA significantly lowered T levels, testis weights, and sperm count, and vitamin E could attenuate it ( 114 ).…”

Section: Action Of Bpamentioning

confidence: 99%

Bisphenols and Leydig Cell Development and Function

Zhu²,

Wang

et al. 2020

Front. Endocrinol.

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Bisphenol A (BPA) is a ubiquitous environmental pollutant, mainly from the production and use of plastics and the degradation of wastes related to industrial plastics. Evidence from laboratory animal and human studies supports the view that BPA has an endocrine disrupting effect on Leydig cell development and function. To better understand the adverse effects of BPA, we reviewed its role and mechanism by analyzing rodent data in vivo and in vitro and human epidemiological evidence. BPA has estrogen and anti-androgen effects, thereby destroying the development and function of Leydig cells and causing related reproductive diseases such as testicular dysgenesis syndrome, delayed puberty, and subfertility/infertility. Due to the limitation of BPA production, the increased use of BPA analogs has also attracted attention to these new chemicals. They may share actions and mechanisms similar to or different from BPA.

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Protective effect of Cordyceps militaris extract against bisphenol A induced reproductive damage

Cited by 41 publications

References 37 publications

Effects of superfine grinding on the properties and qualities of Cordyceps militaris and its spent substrate

Effects of superfine grinding on the properties and qualities of Cordyceps militaris and its spent substrate

Cordyceps militarisImproves Chronic Kidney Disease by Affecting TLR4/NF-κB Redox Signaling Pathway

Bisphenols and Leydig Cell Development and Function

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