Influence of variation in the catechol-O-methyltransferase gene on the clinical outcome after lumbar spine surgery for one-level symptomatic disc disease: a report on 176 cases

Rut, Marcin; Machoy-Mokrzyńska, Anna; Ręcławowicz, Daniel; Słoniewski, Paweł; Kurzawski, Mateusz; Droździk, Marek; Safranow, Krzysztof; Morawska, Michalina; Białecka, Monika

doi:10.1007/s00701-013-1895-6

Cited by 48 publications

(36 citation statements)

References 30 publications

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“…In particular, three genes have shown consistent associations with both experimental and clinical pain responses: the catechol-O-methyl transferase gene ( COMT ), the mu-opioid receptor gene ( OPRM1 ), and the GTP-cyclohydrolase gene ( GCH1 ) [115]. Regarding COMT , polymorphisms and haplotypes have been associated with laboratory pain sensitivity, and acute and chronic clinical pain [13,40], including long-term outcomes after back surgery [143]. Similarly, the A118G polymorphism of OPRM1 has been associated with experimental pain sensitivity and with clinical pain [53,71,123], including long-term outcomes of acute back pain [124].…”

Section: General Considerationsmentioning

confidence: 99%

Research design considerations for chronic pain prevention clinical trials

Gewandter

Dworkin

Turk

et al. 2015

Pain

130

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Although certain risk factors can identify individuals who are most likely to develop chronic pain, few interventions to prevent chronic pain have been identified. To facilitate the identification of preventive interventions, an IMMPACT meeting was convened to discuss research design considerations for clinical trials investigating the prevention of chronic pain. We present general design considerations for prevention trials in populations that are at relatively high risk for developing chronic pain. Specific design considerations included subject identification, timing and duration of treatment, outcomes, timing of assessment, and adjusting for risk factors in the analyses. We provide a detailed examination of 4 models of chronic pain prevention (i.e., chronic post-surgical pain, postherpetic neuralgia, chronic low back pain, and painful chemotherapy-induced peripheral neuropathy). The issues discussed can, in many instances, be extrapolated to other chronic pain conditions. These examples were selected because they are representative models of primary and secondary prevention, reflect persistent pain resulting from multiple insults (i.e., surgery, viral infection, injury, and toxic/noxious element exposure), and are chronically painful conditions that are treated with a range of interventions. Improvements in the design of chronic pain prevention trials could improve assay sensitivity and thus accelerate the identification of efficacious interventions. Such interventions would have the potential to reduce the prevalence of chronic pain in the population. Additionally, standardization of outcomes in prevention clinical trials will facilitate meta-analyses and systematic reviews and improve detection of preventive strategies emerging from clinical trials.

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Section: General Considerationsmentioning

confidence: 99%

Research design considerations for chronic pain prevention clinical trials

Gewandter

Dworkin

Turk

et al. 2015

Pain

130

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“…Andrade et al [38, 39] used >20% reduction in VAS while Rut et al [40] and Takeuchi et al [41] used >50% reduction in VAS between baseline and follow to define recovery. Specific description of change in pain state during the follow up period was reported in just two of the studies.…”

Section: Resultsmentioning

confidence: 99%

“…In both men and women, carriers of COMT rs4680 2G alleles had more pain than carriers of two A alleles at 6 months after disc herniation. Conversely, Rut et al [40] reported that carriers of two COMT rs4680 G alleles may be associated with significant positive improvement in pain recovery one year after surgery.…”

Section: Resultsmentioning

confidence: 99%

Genes associated with persistent lumbar radicular pain; a systematic review

Bjorland

Møen

Schistad

et al. 2016

BMC Musculoskelet Disord

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BackgroundThe aim of the present study was to provide an overview of the literature addressing the role of genetic factors and biomarkers predicting pain recovery in newly diagnosed lumbar radicular pain (LRP) patients.MethodsThe search was performed in Medline OVID, Embase, PsycInfo and Web of Science (2004 to 2015). Only prospective studies of patients with LRP addressing the role of genetic factors (genetic susceptibility) and pain biomarkers (proteins in serum) were included. Two independent reviewers extracted the data and assessed methodological quality.ResultsThe search identified 880 citations of which 15 fulfilled the inclusion criteria. Five genetic variants; i.e., OPRM1 rs1799971 G allele, COMT rs4680 G allele, MMP1 rs1799750 2G allele, IL1α rs1800587 T allele, IL1RN rs2234677 A allele, were associated with reduced recovery of LRP. Three biomarkers; i.e., TNFα, IL6 and IFNα, were associated with persistent LRP.ConclusionThe present results indicate that several genetic factors and biomarkers may predict slow recovery in LRP. Still, there is a need for replication of the findings. A stricter use of nomenclature is also highly necessary.Trial registrationThe review is registered PROSPERO 20th of November 2015. Registration number is CRD42015029125.

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“…According to their results, GG homozygotes are decidedly more resistant to pain stimuli than AA [24,25].…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of catechol-O-methyltransferase ( COMT rs4680:G>A ) and μ-opioid receptor ( OPRM1 rs1799971:A >G ) in relation to pain perception in combat athletes

Leźnicka¹,

Kurzawski²,

Cięszczyk³

et al. 2017

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ABSTRACT:In athletes, pain has diverse functions and a complex etiology. Its role is not limited to indicating the limits of the body, especially in areas that are exposed to maximal forces and stresses and consequently vulnerable to damage or injury. Several common single nucleotide polymorphisms (SNPs) have been recently associated with inter-individual differences in pain perception. Among several other markers, catechol-O-methyltransferase (COMT rs4680:G>A) and the µ-opioid receptor (OPRM1 rs1799971:A >G) were proposed as key factors for pain perception. The aim of the current study was to investigate the potential association between COMT and OPRM1 genotypes and pain perception as well as the relation with elite athlete status. The study involved 395 healthy men, aged 18 to 28 years; 214 combat sports athletes comprised the experimental group and 181 non-athletes comprised the control group. DNA was extracted from buccal cells donated by the subjects, and genotyping for COMT rs4680 and OPRM1 rs1799971 was carried out using realtime PCR. Measurement of the pain threshold and pain tolerance was performed using an algometer and the cold pressor test. The genotype distribution of COMT and OPRM1 polymorphisms did not differ between combat athletes and the control group (p=0.500 and p=0.390). Pain threshold and pain tolerance as both quantitative and qualitative measures did not differ with respect to OPRM1 and COMT polymorphism in either the combat or the control group for any of the analysed genetic models. CITATION:

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Influence of variation in the catechol-O-methyltransferase gene on the clinical outcome after lumbar spine surgery for one-level symptomatic disc disease: a report on 176 cases

Cited by 48 publications

References 30 publications

Research design considerations for chronic pain prevention clinical trials

Research design considerations for chronic pain prevention clinical trials

Genes associated with persistent lumbar radicular pain; a systematic review

Polymorphisms of catechol-O-methyltransferase ( COMT rs4680:G>A ) and μ-opioid receptor ( OPRM1 rs1799971:A >G ) in relation to pain perception in combat athletes

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