Genes associated with persistent lumbar radicular pain; a systematic review

Bjorland, Siri; Møen, Atle; Schistad, Ellina Iordanova; Gjerstad, Johannes; Røe, Cecilie

doi:10.1186/s12891-016-1356-5

Cited by 21 publications

(14 citation statements)

References 59 publications

(100 reference statements)

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“…Earlier data suggest that the heritability of back pain range from 30 to 45% [16]. Genetic variability, which is important for degenerative changes, inflammation or pain perception may play a role in both LBP and LRP conditions [17–21]. Genetic variants in genes encoding proteins such as vitamin D receptor (VDR), collagens (COL) and matrix metalloproteinases (MMPs) may affect degeneration of the intervertebral discs [18, 22].…”

Section: Introductionmentioning

confidence: 99%

Persistent lumbar radicular and low back pain; impact of genetic variability versus emotional distress

et al. 2019

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Objective Earlier studies documenting the effect of candidate genes on recovery have seldom taken into consideration the impact of emotional distress. Thus, we aimed to assess the modifying effect of emotional distress on genetic variability as a predictor for pain recovery in lumbar radicular (LRP) and low back pain (LBP). Results The study population comprised 201 patients and mean age was 41.7 years. The significant association between MMP9 rs17576 (B = 0.71, 95% CI 0.18 to 1.24, p = 0.009) and pain recovery remained statistically significant after adjusting for pain intensity at baseline, age, gender, smoking, body mass index, pain localization and emotional distress (B = 0.68, 95% CI 0.18 to 1.18, p = 0.008). In contrast, the association between OPRM1 (B = − 0.85, 95% CI − 1.66 to − 0.05, p = 0.038) and pain recovery was abolished in the multivariate analysis (B = − 0.72, 95% CI − 1.46 to 0.02, p = 0.058). Hence, MMP9 rs17576 and emotional distress independently seem to predict persistent back pain. The predictive effect of OPRM1 rs179971 with regard to the same outcome is probably dependent on other factors including emotional processing. Trial registration The Regional Committee for Medical Research and Ethics reference number 2014/1754

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Section: Introductionmentioning

confidence: 99%

Persistent lumbar radicular and low back pain; impact of genetic variability versus emotional distress

et al. 2019

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“…To this end, we wanted to explore whether or not the genetic polymorphisms of cytokines affect the dosage of PCIA sufentanil after radical lung cancer surgery. After reviewing the available studies, we found that IL-1A, 24,[29][30][31] IL-1β, 24,29,31,32 IL-1RN, 24,29,33 IL-6, 24,29,34,35 CXCL8, 24,29,35,36 IL-10, 24,29 TNF, 20,24,28 NFκB1, 24,29,37 REL 37 and NFκBIA 24,37 are closely related to pain. After searching the NCBI SNP database (http://www.…”

Section: Discussionmentioning

confidence: 99%

<p>Genetic Polymorphisms of Cytokines Might Affect Postoperative Sufentanil Dosage for Analgesia in Patients</p>

Guo

Yuan

Yang

et al. 2020

JPR

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To explore the effect of genetic polymorphisms of cytokines on the dosage of sufentanil for patient-controlled intravenous analgesia (PCIA) after radical lung cancer surgery. Methods: A total of 100 patients, aged 18 years and above, with ASA grade Ⅰ-Ⅱ and body mass index (BMI) 18.5 to 30, and who were scheduled for radical lung cancer surgery under total intravenous anaesthesia with PCIA of sufentanil from September 2015 to March 2016, were selected. DNA was collected from peripheral blood samples before surgery, and the iMLDRTM multiple single-nucleotide polymorphism typing kit was used to detect 16 related single-nucleotide polymorphism (SNP) sites of interleukin-1A (IL-1A), interleukin-1β (IL-1β), interleukin-1RN (IL-1RN), interleukin-6 (IL-6), C-X-C motif chemokine ligand 8 (CXCL8), interleukin-10 (IL-10), tumour necrosis factor (TNF), nuclear factor kappa-B1 (NFκB1), REL (REL protooncogene, NF-kB subunit), and nuclear factor kappa-B inhibitor alpha (NFκBIA). The general characteristics of patients, surgery and anaesthesia data, postoperative resting VAS pain scores, postoperative opioid dosages of sufentanil for PCIA and opioid-related adverse events were recorded. The effects of the examined genetic polymorphisms of the cytokines on the dosage of sufentanil were analysed. Results: Eight of 100 patients withdrew for various reasons, and, eventually, 92 patients were included. The patients' resting visual analogue scale (VAS) scores at 24 h, 48 h, and 72 h after surgery were 2.3 ± 1.2, 2.0 ± 0.9, and 1.9 ± 1.0, respectively. The total amounts of sufentanil used were 34.7 ± 10.5 μg, 65.2 ± 13.7 μg, and 94.7 ± 11.6 μg, respectively. We found that the TT genotype of NFκBIA rs696 had higher PCIA sufentanil dosages than the CC genotype and the CT genotype at 48-72 h postoperation (p=0.023, p=0.025, respectively). Conclusion:The genetic polymorphisms of the cytokine NFκBIA rs696 might affect the dosage of sufentanil for PCIA after radical lung cancer surgery. The specific mechanism needs further study.

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“…Other anti-inflammatory cytokines such as IL-1, IL-6, and COX 2 are associated with DDD and pain related to DDD [85]. Systematic Review on genes and biomarkers for pain in DDD shows that five genetic variants; i.e., OPRM1 rs1799971 G allele, COMT rs4680 G allele, MMP1 rs1799750 2G allele, IL1α rs1800587 T allele, IL1RN rs2234677 A allele, were associated with reduced recovery of lower back pain and three biomarkers; i.e., TNFα, IL6 and IFNα, were associated with persistent back pain [86]. In our endoscopic videos analysis, we found the presence of grade 2 and 3 neovascularization associated with all cases which required sinuvertebral and basivertebral nerves ablation.…”

Section: Inflammatory Processesmentioning

confidence: 99%

Lumbar Degenerative Disease Part 1: Anatomy and Pathophysiology of Intervertebral Discogenic Pain and Radiofrequency Ablation of Basivertebral and Sinuvertebral Nerve Treatment for Chronic Discogenic Back Pain: A Prospective Case Series and Review of Literature

Kim

Jang

2020

IJMS

114

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Degenerative disc disease is a leading cause of chronic back pain in the aging population in the world. Sinuvertebral nerve and basivertebral nerve are postulated to be associated with the pain pathway as a result of neurotization. Our goal is to perform a prospective study using radiofrequency ablation on sinuvertebral nerve and basivertebral nerve; evaluating its short and long term effect on pain score, disability score and patients’ outcome. A review in literature is done on the pathoanatomy, pathophysiology and pain generation pathway in degenerative disc disease and chronic back pain. 30 patients with 38 levels of intervertebral disc presented with discogenic back pain with bulging degenerative intervertebral disc or spinal stenosis underwent Uniportal Full Endoscopic Radiofrequency Ablation application through either Transforaminal or Interlaminar Endoscopic Approaches. Their preoperative characteristics are recorded and prospective data was collected for Visualized Analogue Scale, Oswestry Disability Index and MacNab Criteria for pain were evaluated. There was statistically significant Visual Analogue Scale improvement from preoperative state at post-operative 1wk, 6 months and final follow up were 4.4 ± 1.0, 5.5 ± 1.2 and 5.7 ± 1.3, respectively, p < 0.0001. Oswestery Disability Index improvement from preoperative state at 1week, 6 months and final follow up were 45.8 ± 8.7, 50.4 ± 8.2 and 52.7 ± 10.3, p < 0.0001. MacNab criteria showed excellent outcomes in 17 cases, good outcomes in 11 cases and fair outcomes in 2 cases Sinuvertebral Nerve and Basivertebral Nerve Radiofrequency Ablation is effective in improving the patients’ pain, disability status and patient outcome in our study.

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Genes associated with persistent lumbar radicular pain; a systematic review

Cited by 21 publications

References 59 publications

Persistent lumbar radicular and low back pain; impact of genetic variability versus emotional distress

Persistent lumbar radicular and low back pain; impact of genetic variability versus emotional distress

<p>Genetic Polymorphisms of Cytokines Might Affect Postoperative Sufentanil Dosage for Analgesia in Patients</p>

Lumbar Degenerative Disease Part 1: Anatomy and Pathophysiology of Intervertebral Discogenic Pain and Radiofrequency Ablation of Basivertebral and Sinuvertebral Nerve Treatment for Chronic Discogenic Back Pain: A Prospective Case Series and Review of Literature

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