Influence of Ultrasound and Physical Activity on Bone Healing

Guerino, Marcelo Renato; Santi, Francisco Pereira; Silveira, Rafael Fernando; Luciano, Eliete

doi:10.1016/j.ultrasmedbio.2008.02.006

Cited by 8 publications

(5 citation statements)

References 26 publications

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“…Between the methods available to enhance musculoskeletal disorders healing, US has suggested as a safe, practical, and effective treatment. [22,28,34,35] In our opinion, extensive clinical and experimental and long-term studies investigating biophysical mechanisms of LIPUS are required.…”

Section: Resultsmentioning

confidence: 99%

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Rashidi

2017

AJP

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Ultrasound (US) waves due to their unique features can be a treatment option for osteoporosis. Initial studies have shown promising but controversial outcomes. Several preclinical and clinical studies have been conducted on osteoporosis and studies are ongoing to find optimum US parameters, mechanisms of action, and therapeutic efficacies of these techniques for osteoporosis treatment. This paper was aimed to review the recent advances of using US waves in the treatment of osteoporosis and possible mechanisms of actions. The databases of PubMed (1980PubMed ( -2016, EMBASE (1980EMBASE ( -2016, Web of Sciences (1980-2016), and Google Scholar (1980-2016 were searched using the set terms. The obtained records were reviewed, and relevant studies were selected for comprehensive review of the current literature. Low-intensity pulsed US (LIPUS) has biological effects on the bone healing process and it can accelerate bone regeneration. Current evidence is limited on the efficacy of US waves for treatment or prevention of osteoporosis; however, the initial studies are promising. The US waves can promote osteoblast and inhibit osteoclast, enhance angiogenesis, trigger expression of different genes associated with osteogenesis. No definite dose-response existed on the clinical trials of US wave applications. The current evidence shows the therapeutic efficacy of US waves particularly LIPUS for osteoporosis treatment; however, to observe therapeutic outcomes long-term US stimulation is required. No definitive dose-response is proposed for osteoporosis. Further in vitro and clinical trials should be conducted to develop US-based techniques for the treatment of osteoporosis as a clinical treatment option.

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Section: Resultsmentioning

confidence: 99%

“…The finding suggested that LIPUS therapy, if scaled for whole body use, has clear clinical benefits for the treatment of osteoporosis. [22,[35][36][37] …”

Section: Lipus and Osteoporosismentioning

confidence: 99%

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Rashidi

2017

AJP

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“…Leung et al [28], using LIPUS equipment designed for bone healing, showed that treatment for 20 min per day at 30 mW/cm 2 increased levels of alkaline phosphatase. Guerino et al [29] suggested that an increased level of alkaline phosphatase seen with TUS is possibly associated with increased cell proliferation and mineralization.…”

Section: Discussionmentioning

confidence: 99%

The influence of low-intensity physiotherapeutic ultrasound on the initial stage of bone healing in rats: an experimental and simulation study

et al. 2016

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BackgroundLow-intensity physiotherapeutic ultrasound has been used in physical therapy clinics; however, there remain some scientific issues regarding the bone-healing process. The objective of this study was to investigate the influence of low-intensity physiotherapeutic ultrasound on the initial stage of bone healing in rats.MethodsTwenty-two male adult rats were assessed quantitatively and qualitatively using radiographic, biochemical, and histological analyses. Numerical simulations were also performed. Fractures in animals in the ultrasound group (n = 11) were treated with low-intensity ultrasound (pulsed mode, duty cycle 20 %) for 10 min daily at an intensity of 40 mW/cm2 SATA (1.0 MHz) for 10 days. Fractures in animals in the control group (n = 11) were not treated.ResultsAlkaline phosphatase levels were non-significantly higher in the ultrasound group than in the control group in the time intervals considered (t(13) = 0.440; 95 % confidence interval (CI) −13.79 to 20.82; p = 0.67). Between-group serum calcium levels were also not significantly different (t(13) = −0.842; 95 % CI −0.48 to 0.21; p = 0.42). Finally, there were no significant differences in radiological scores between the two groups (U = 118; 95 % CI −1.99 to 1.99; p = 0.72). However, the diameter of the newly formed bone tissue was greater and more evident in the ultrasound group.ConclusionsThirteen days after fracture, there was no significant between-group differences in bone-healing processes, although the increased alkaline phosphatase levels and diameter of new bone tissue need to be further investigated.

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“…A ocorrência de mobilidade nula, verificada por meio do teste manual de mobilidade da fratura nos animais submetidos ao protocolo de natação (grupos G2 e G3) em comparação com o maior grau de mobilidade evidenciada nos grupos controle e G1, corrobora a hipótese de que a atividade física acelera o processo de reparo da fratura (16,17). Destacase, ainda, que o tamanho do calo ósseo parece ser um fator determinante na ausência de mobilidade ao teste manual de mobilidade da fratura, visto que se observou calo ósseo significativamente maior no grupo G3 em comparação com o grupo controle (p < 0,05), além de haver tendência ao aumento de formação do calo ósseo em G2 (Quadro 2).…”

Section: Discussionunclassified

Efeito do exercício físico e da administração de testosterona na consolidação de fraturas de tíbia em ratos

et al. 2012

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Fisioter Mov. 2012 out/dez;25(4):777-84 ISSN 0103-5150 Fisioter. Mov., Curitiba, v. 25, n. 4, p. 777-784, out./dez. 2012 Licenciado sob uma Licença Creative Commons [T] Efeito do exercício físico e da administração de testosterona na consolidação de fraturas de tíbia em ratos [I] Effects of exercise and testosterone administration on tibia fracture healing in rats [A] Francisco Valmor Macedo Cunha [a] , Oséas Florêncio de Moura Filho [b] , Felipe Scipião Moura Resumo Introdução: Vários estudos têm sido realizados visando identificar um medicamento que acelere a consolidação de fraturas. Objetivo: Avaliar o efeito do exercício físico e da administração de testosterona no processo de consolidação de fratura de tíbia e fíbula de ratos. Materiais e métodos: Rattus norvegicus (250 a 300 g) foram distribuídos aleatoriamente em quatro grupos de oito animais: Controle-fratura e imobilização; G1-fratura, imobilização e propionato de testosterona; G2-fratura, imobilização e treinamento físico de natação; G3-fratura, imobilização, treinamento físico de natação e propionato de testosterona. Os tratamentos foram iniciados imediatamente após a realização de fraturas fechadas no terço médio da tíbia direita. O programa de treinamento físico consistiu em 50 minutos de natação durante quatro semanas, cinco vezes por semana. O propionato de testosterona 3 mg/kg foi administrado por via subcutânea cinco vezes na semana durante quatro semanas. As variáveis analisadas incluíram evolução ponderal, tamanho do calo ósseo, níveis séricos de fósforo, cálcio, albumina, proteínas totais e atividade da fosfatase alcalina. Resultados: O tamanho do calo ósseo foi maior no grupo submetido a tratamento combinando imobilização, exercício físico e testosterona. Os grupos tratados com testosterona combinada ou não a programa de natação apresentaram maiores níveis de fósforo e de fosfatase alcalina, além de menores níveis de proteínas totais e albumina. Conclusão: O grupo submetido ao programa de treinamento físico de natação combinado com a administração de testosterona obteve melhor consolidação óssea evidenciada pelo maior calo ósseo e atividade aumentada da fosfatase alcalina, sugerindo maior rapidez no processo de consolidação óssea.[P]Palavras-chave: Exercício físico. Testosterona. Consolidação da fratura.[

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Influence of Ultrasound and Physical Activity on Bone Healing

Cited by 8 publications

References 26 publications

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The influence of low-intensity physiotherapeutic ultrasound on the initial stage of bone healing in rats: an experimental and simulation study

Efeito do exercício físico e da administração de testosterona na consolidação de fraturas de tíbia em ratos

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