Influence of two different types of excipient on drug percolation threshold

Percolative drug diffusion from cylindrical matrix systems with unsealed boundaries

“…The drug‐release percolation threshold of ∼ 0.22 found in the present study – in which the NaCl was allowed to escape the cylindrical EC matrix in both axial and radial directions – is significantly lower than the value of ∼0.31–0.38 found for the release of caffeine8 and KCl45 from similar systems allowing for axial release only. It should be noted that drugs and excipients of particle sizes and drug‐to‐excipient‐size ratios both smaller45 and larger8 than those employed in the present study have been used in the above referred to investigations, thus ruling out differences in particle size as a possible explanation for the percolation threshold in the present work being lower than previously obtained values. This finding indicates that – at a given tablet porosity and tablet size – the probability of a pore being in contact with the surrounding release medium increases as more tablet surface is being exposed to the medium.…”

Three-Dimensional Printing of Drug-Eluting Implants: Preparation of an Antimicrobial Polylactide Feedstock Material

“…The release behavior has been studied for systems with similar physicochemical properties, that is, matrix tablets, and can be modeled by the site-bond percolation theory. [25][26][27] As evident from the results of this study, the NF drug loading of the PLA feedstock materials was too low, even at 30% NF, to facilitate a complete release upon dissolution. This could partly explain the higher accumulated release of the 30% NF samples compared with that of 10% or 20% NF, as the percolation of NF domains inside the material increases with drug loading as evident from the EDX-SEM images ( Figs.…”

“…The release behavior has been studied for systems with similar physicochemical properties, that is, matrix tablets, and can be modeled by the site‐bond percolation theory . As evident from the results of this study, the NF drug loading of the PLA feedstock materials was too low, even at 30% NF, to facilitate a complete release upon dissolution.…”

Development of extended-release solid dispersion granules of tacrolimus: evaluation of release mechanism and human oral bioavailability

“…One capsule containing 5 mg of tacrolimus was orally administered with 150 ml of water. Three millilitres of blood samples was collected before oral administration (0 h), and at 0.5, 1, 2, 3, 4, 5, 6,7,8,9,10,11,12,13,14,15,16,18,24,36,48 and 72 h postoral administration. Whole blood samples were drawn into an EDTA Vacutainer â (lavender top; Becton, Dickinson and Company: 1 Becton Drive, Franklin Lakes, NJ, USA), mixed by gentle inversion (human EDTA whole blood sample) and frozen at À20°C until used.…”