Influence of tumor stage, symptoms, and time of blood draw on serum concentrations of organochlorine compounds in exocrine pancreatic cancer

Porta, Miquel; Pumarega, José; López, Tomás; Jariod, Manuel; Marco, Esther; Grimalt, Joan O.

doi:10.1007/s10552-009-9383-2

Cited by 26 publications

(43 citation statements)

References 49 publications

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“…This assumption following Philips et al (1989) and Porta et al (2009b) was held for monitored populations, considering they revealed not significant changes in lipid concentrations during the monitoring study. The obtained results of our monitored samples are presented in table I.…”

Section: Resultsmentioning

confidence: 80%

“…Concentrations of organochlorine pesticides are in a state of equilibrium between blood serum and adipose tissue or other lipid-rich tissues (Phillips et al 1989, Porta et al 2009b). This assumption following Philips et al (1989) and Porta et al (2009b) was held for monitored populations, considering they revealed not significant changes in lipid concentrations during the monitoring study.…”

Section: Resultsmentioning

confidence: 99%

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Comparison of Organochlorine Pesticide Levels Between Human Blood Serum and Adipose Tissue

Martínez-Valenzuela

Waliszewski

Gómez‐Arroyo

et al. 2017

Rev. Int. Contam. Ambie.

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The organochlorine pesticides, being lipophilic compounds, show extremely high thermodynamic stability and resistance to degradation processes in the environment and in living organisms. They accumulate in lipid rich tissues and distribute between transport compartment (blood) and store compartment (adipose tissue). The purpose of this study is to make a comparison between organochlorine pesticide levels in blood serum and adipose tissue and calculate the differences in their concentrations based on routine biomonitoring study. One hundred and twenty six pair samples of adipose tissue and blood serum during autopsies as a case study were taken and analyzed in Los Mochis Sinaloa, México. Among organochlorine pesticides, higher concentrations correspond to b-HCH, pp'DDE and op'DDT in blood serum lipids; and pp'DDT shows higher concentrations in adipose tissue. Using statistical comparisons, we found a significant linear association of lipid serum organochlorine pesticide concentrations with that in adipose tissue. This concludes that serum lipid organochlorine pesticide concentrations represent an important indicator for both human biological matrices.Palabras clave: plasma, tejido graso, toxicocinética, matrices biológicas 394organismos vivos. Se acumulan en tejidos ricos en lípidos y se distribuyen entre el compartimento de transporte (sangre) y el compartimento de almacenamiento (tejido adiposo). El objetivo de este estudio fue comparar los niveles de plaguicidas organoclorados en suero sanguíneo y tejido adiposo, así como calcular sus diferencias en concentraciones en ambas matrices biológicas, tomando como base un estudio rutinario de biomonitoreo. Ciento veintiséis pares de muestras de suero sanguíneo y tejido adiposo fueron tomadas durante autopsias y analizadas como estudios de caso en Los Mochis, Sinaloa México. Entre las concentraciones más altas de plaguicidas organoclorados en lípidos de suero sanguíneo, se encuentra el b-HCH, pp´DDE y op´DDT, mientras que en el tejido adiposo el insecticida organoclorado pp'DDT reveló mayor concentración. Aplicando comparaciones estadísticas, se calculó una asociación lineal significativa entre las concentraciones de plaguicidas organoclorados en lípidos del suero sanguíneo comparandas con las del tejido adiposo. Esto permite concluir que las concentraciones de plaguicidas organoclorados en los lípidos del suero sanguíneo, representan un importante indicador para ambas matrices biológicas humanas.

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Section: Resultsmentioning

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Comparison of Organochlorine Pesticide Levels Between Human Blood Serum and Adipose Tissue

Martínez-Valenzuela

Waliszewski

Gómez‐Arroyo

et al. 2017

Rev. Int. Contam. Ambie.

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“…*The reference category for all models includes groups 1 to 4 of ISCO 88.†All models are adjusted for age, sex, tumour stage and cholestatic syndrome 27 29‡

Regression coefficient.

…”

Section: Methodsmentioning

confidence: 99%

Relationships between occupational history and serum concentrations of organochlorine compounds in exocrine pancreatic cancer

et al. 2010

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Certain occupations were associated with higher concentrations of PCBs, suggesting that these compounds may account for some increased risks found in previous studies. The lack of association between work in agriculture and concentrations of OC pesticides is consistent with occupation playing a lesser role than diet in influencing OC concentrations. Occupational studies on the relationships among exposure to industrial agents and EPC risk may need to consider adjusting for exposure to PCBs.

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“…The following items should be reported: 1) the setting of the biological sample collection (place, time of the day, time of the year, laboratories involved, personnel involved, etc); 2) amount/volume/size of sample(s); 3) nature of the collecting procedure (anticoagulant involved, e.g., heparin, EDTA) 4) if the participant is healthy, participant condition at the sample collection (fasting status, position, etc) when appropriate; 5) if participants are not healthy individuals in stable physiological conditions, then report the relevant aspects of the health status and clinical conditions of the participants24 25; 6) in all instances, consider reporting the time between sample collection and relevant clinical or physiological endpoints that might have affected the characteristics or concentrations of the biomarker 26. In particular, report any relevant characteristic of the participants which might influence the biomarker levels in any known or unknown way.…”

Section: Checklist Of Itemsmentioning

confidence: 99%

STrengthening the Reporting of OBservational studies in Epidemiology: Molecular Epidemiology STROBE-ME. An extension of the STROBE statement

Gallo

Egger

McCormack

et al. 2011

J Epidemiol Community Health

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Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change, susceptibility, and clinical outcomes are used as proxies for investigating the interactions between external and/or endogenous agents and the body components or processes. The need for improved reporting of scientific research led to influential statements of recommendations such as STrengthening Reporting of Observational studies in Epidemiology (STROBE) statement. The STROBE initiative established in 2004 aimed to provide guidance on how to report observational research. Its guidelines provide a user-friendly checklist of 22 items to be reported in epidemiological studies, with items specific to the three main study designs: cohort studies, case-control studies and cross-sectional studies. The present STrengthening the Reporting of OBservational studies in Epidemiology –Molecular Epidemiology(STROBE-ME) initiative builds on the STROBE Statement implementing 9 existing items of STROBE and providing 17 additional items to the 22 items of STROBE checklist. The additions relate to the use of biomarkers in epidemiological studies, concerning collection, handling and storage of biological samples; laboratory methods, validity and reliability of biomarkers; specificities of study design; and ethical considerations. The STROBE-ME recommendations are intended to complement the STROBE recommendations.

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Influence of tumor stage, symptoms, and time of blood draw on serum concentrations of organochlorine compounds in exocrine pancreatic cancer

Abstract: Restriction or adjustment by stage and timing of blood draw may be insufficient to prevent biases associated with cancer progression. Symptoms may enable investigators to assess disease-induced changes in lipophilic exposure biomarkers.

Cited by 26 publications

References 49 publications

Comparison of Organochlorine Pesticide Levels Between Human Blood Serum and Adipose Tissue

Comparison of Organochlorine Pesticide Levels Between Human Blood Serum and Adipose Tissue

Relationships between occupational history and serum concentrations of organochlorine compounds in exocrine pancreatic cancer

STrengthening the Reporting of OBservational studies in Epidemiology: Molecular Epidemiology STROBE-ME. An extension of the STROBE statement

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