Influence of Trp64Arg Polymorphism of Beta 3-Adrenoreceptor Gene on Insulin Resistance, Adipocytokines and Weight Loss Secondary to Two Hypocaloric Diets

Luis, Daniel Antonio de; Sagrado, M. González; Aller, R.; Izaola, Olatz; Conde, Rosa

doi:10.1159/000209268

Cited by 16 publications

(12 citation statements)

References 56 publications

(33 reference statements)

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“…More detailed serum chemistry (such as inflammatory cytokines and adipokines) depended on the specific context and primary outcome indicators of each study. Given the potential for affective disorders to affect inflammatory cytokine levels, 19,27 it is noteworthy that 4 of the 15 trials measured tumour necrosis factor alpha and interleukin-6, [28][29][30][31] which are known to be affected by Psychosocial characterisation in dietary weight-loss RCTs SM Somerset et al psychological factors, but none assessed subjects for associated psychological attributes. In terms of psychosocial characterisation of subjects at baseline, data collection could best be described as weak.…”

Section: Discussionmentioning

confidence: 99%

A systematic review of baseline psychosocial characterisation in dietary randomised controlled trials for weight loss

2013

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BACKGROUND/OBJECTIVE: To investigate the extent of baseline psychosocial characterisation of subjects in published dietary randomised controlled trials (RCTs) for weight loss. SUBJECTS/METHODS: Systematic review of adequately sized (nX10) RCTs comprising X1 diet-alone arm for weight loss were included for this systematic review. More specifically, trials included overweight (body mass index 425 kg/m 2 ) adults, were of duration X8 weeks and had body weight as the primary outcome. Exclusion criteria included specific psychological intervention (for example, Cognitive Behaviour Therapy (CBT)), use of web-based tools, use of supplements, liquid diets, replacement meals and very-low calorie diets. Physical activity intervention was restricted to general exercise only (not supervised or prescribed, for example, VO 2 maximum level). RESULTS: Of 176 weight-loss RCTs published during 2008-2010, 15 met selection criteria and were assessed for reported psychological characterisation of subjects. All studies reported standard characterisation of clinical and biochemical characteristics of subjects. Eleven studies reported no psychological attributes of subjects (three of these did exclude those taking psychoactive medication). Three studies collected data on particular aspects of psychology related to specific research objectives (figure scale rating, satiety and quality-of-life). Only one study provided a comprehensive background on psychological attributes of subjects. CONCLUSION: Better characterisation in behaviour-change interventions will reduce potential confounding and enhance generalisability of such studies.

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Section: Discussionmentioning

confidence: 99%

A systematic review of baseline psychosocial characterisation in dietary randomised controlled trials for weight loss

2013

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“…Though limited, there is some evidence to suggest that ADRB receptor polymorphisms interact with dietary nutrients (de Luis et al, 2009) and may also be involved in regulating food intake. In adults, ADRB3 Trp64Arg appears to interact with carbohydrate preference/consumption (Aoyama et al, 2003), and may also operate synergistically with PPARG variants to modulate satiety expression (Cecil et al, 2007).…”

Section: Adrenergic Receptor Gene Variants -A Role In Polygenic Obesimentioning

confidence: 99%

Obesity and eating behaviour in children and adolescents: Contribution of common gene polymorphisms

Cecil

Dalton

Finlayson

et al. 2012

International Review of Psychiatry

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The prevalence of childhood obesity is increasing in many countries and confers risks for early type 2 diabetes, cardiovascular disease and metabolic syndrome. In the presence of potent ' obesogenic ' environments not all children become obese, indicating the presence of susceptibility and resistance. Taking an energy balance approach, susceptibility could be mediated through a failure of appetite regulation leading to increased energy intake or via diminished energy expenditure. Evidence shows that heritability estimates for BMI and body fat are paralleled by similar coeffi cients for energy intake and preferences for dietary fat. Twin studies implicate weak satiety and enhanced food responsiveness as factors determining an increase in BMI. Single gene mutations, for example in the leptin receptor gene, that lead to extreme obesity appear to operate through appetite regulating mechanisms and the phenotypic response involves overconsumption and a failure to inhibit eating. Investigations of robustly characterized common gene variants of fat mass and obesity associated ( FTO ), peroxisome proliferator-activated receptor ( PPARG ) and melanocortin 4 receptor ( MC4R ) which contribute to variance in BMI also infl uence the variance in appetite factors such as measured energy intake, satiety responsiveness and the intake of palatable energy-dense food. A review of the evidence suggests that susceptibility to childhood obesity involving specifi c allelic variants of certain genes is mediated primarily through food consumption (appetite regulation) rather than through a decrease in activity-related energy expenditure. This conclusion has implications for early detection of susceptibility, and for prevention and management of childhood obesity.

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“…Therefore, interaction between gene and environmental factors, such as dietary treatments (25,26), could influence in development metabolic syndrome in the following years of these patients…”

Section: Discussionmentioning

confidence: 99%

Relation of Trp64Arg polymorphism of beta 3 adrenoreceptor gene with metabolic syndrome and insulin resistance in obese women

et al. 2017

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Background and aim: Trp64Arg variant in beta 3 adrenoreceptor has been reported to be associated with increased body weight and insulin resistance. These risk factors are the ones that make up the so-called metabolic syndrome. The aim of our study was to investigate the relationship between metabolic syndrome and Trp64Arg polymorphism in the beta3 adrenoreceptor gene in obese women. Methods: A population of 531 obese women was analyzed in cross-sectional survey. A bioimpedance, blood pressure, a serial assessment of nutritional intake with 3 days written food records and biochemical analysis were performed. Genotype of beta 3 adrenoreceptor gene polymorphism (Trp64Arg) was studied. Results: Prevalence of metabolic syndrome (MS) with ATP III defi nition was 47.1% (250 patients) and 52.9% patients without MS (n = 281 patients). Prevalence of beta 3 genotypes was similar in patients with metabolic syndrome (87.6% wild genotype and 12.4% mutant genotype) and without metabolic syndrome (87.9% wild genotype and 12.1% mutant genotype). Insulin and HOMA levels were higher in patients with mutant genotype than wild type, in patients with and without metabolic syndrome. Conclusion: In mutant group of beta3 adrenoreceptor gene patients have higher insulin and HOMA levels than wild type group, without relation with metabolic syndrome.

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Influence of Trp64Arg Polymorphism of Beta 3-Adrenoreceptor Gene on Insulin Resistance, Adipocytokines and Weight Loss Secondary to Two Hypocaloric Diets

Cited by 16 publications

References 56 publications

A systematic review of baseline psychosocial characterisation in dietary randomised controlled trials for weight loss

A systematic review of baseline psychosocial characterisation in dietary randomised controlled trials for weight loss

Obesity and eating behaviour in children and adolescents: Contribution of common gene polymorphisms

Relation of Trp64Arg polymorphism of beta 3 adrenoreceptor gene with metabolic syndrome and insulin resistance in obese women

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