Influence of the λ780nm laser light on the repair of surgical bone defects grafted or not with biphasic synthetic micro-granular hydroxylapatite+Beta-Calcium triphosphate

Soares, Luiz Guilherme P.; Marques, Aparecida Maria Cordeiro; Guarda, Milena G.; Aciole, Jouber Mateus S.; Santos, Jean Nunes dos; Pinheiro, António Luiz Barbosa

doi:10.1016/j.jphotobiol.2013.12.015

Cited by 20 publications

(23 citation statements)

References 22 publications

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“…In a previous study it was also mentioned that a usual concern when using granular biomaterials is granulemediated inflammatory reaction (13). In the present study, inflammatory reaction was well documented in all groups where the biomaterial was used.…”

Section: Discussionsupporting

confidence: 74%

“…For periodontal defects, a ratio of 85/15 has been suggested as optimal for repairing surgically created bone defects (13). However, a ratio of 60/40 was mentioned most suitable in a previous animal study (13). In the present study the HA/β-TCP ratio was 70:30, which could be considered within the range for optimal tissue response.…”

Section: Discussionmentioning

confidence: 59%

“…This association makes one part of the graft to be rapidly resorbed (TCP) and the other (HA) remain in situ for a longer period. Possibly higher HA/β-TCP ratios yield more replacement of biomaterial by new bone (13).…”

Section: Discussionmentioning

confidence: 99%

“…It was suggested that 60% HA and 40% β-TCP seemed to provide the optimal bone conductive properties. For periodontal defects, a ratio of 85/15 has been suggested as optimal for repairing surgically created bone defects (13). However, a ratio of 60/40 was mentioned most suitable in a previous animal study (13).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to the several advantages of using this type of biomaterial, it also present disadvantages that include poor mechanical properties, lack of an organic phase, the possibility of the presence of impurities and non-homogenous particle size and shape. Another aspect that influences the results of studies using such type of biomaterials is that the Ca/P ratio may differ according to the manufacturer (13).…”

Section: Discussionmentioning

confidence: 99%

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Repair of Surgical Bone Defects Grafted with Hydroxylapatite + β-TCP and Irradiated with λ=850 nm LED Light

et al. 2015

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The treatment of bone loss due to different etiologic factors is difficult and many techniques aim to improve the repair, including a wide range of biomaterials and recently, photobioengineering. This work aimed to assess by histological analysis the repair of bone defects grafted with biphasic synthetic micro-granular HA + β-TCP associated with LED phototherapy. Forty rats were divided into 4 groups (Clot, LED, Biomaterial and LED + Biomaterial) each subdivided into 2 subgroups according to the time of animal death (15 and 30 days). Surgical bone defects were prepared on the femur of each animal with a trephine drill. In animals of the Clot group the defect was filled only by blood clot, in the LED group the defect filled with the clot was further irradiated. In the animals of Biomaterial and LED + Biomaterial groups the defect was filled by biomaterial and the last one was further irradiated (λ=850±10 nm, 150 mW, Φ ~ 0.5 cm 2 , 20 J/cm 2 -session, 140 J/cm 2 -treatment) at 48-h intervals for 2 weeks. Following animal death, samples were taken and analyzed by light microscopy. Using the degree of maturation of the bone by assessment of the deposition/organization of the basophilic lines in the newly formed bone tissue, the LED + Biomaterial group was the one in a more advanced stage of bone repair process at the end of the experiment. It may be concluded that the use of LED phototherapy was effective in positively modulating the process of bone repair of bone defects in the femur of rats submitted or not to biomaterial grafting.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Repair of Surgical Bone Defects Grafted with Hydroxylapatite + β-TCP and Irradiated with λ=850 nm LED Light

et al. 2015

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Biphasic, Triphasic, and Multiphasic Calcium Orthophosphates

Dorozhkin¹

2016

Advanced Ceramic Materials

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Evaluation of the bony repair in rat cranial defect using near infrared reflectance spectroscopy and discriminant analysis

Lima

Oliveira

et al. 2017

Biotechnology Progress

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We set out to determine whether near infrared reflectance spectroscopy (NIRS) combined with principal component analysis-linear discriminant analysis (LDA) or, variable selection techniques employing successive projection algorithm or genetic algorithm (GA) could evaluate the bone repair in cranial critical-size (5 mm) defect after stimulation with collagen sponge scaffold and/or infrared low-level laser therapy directly on the local. Forty-five Winstar rats were divided into nine groups of five each, namely: group H - healthy, n = 5 (without treatment and without cranial critical-size defect), (GI positive control - n = 5, 21 days or n = 5, 30 days) without treatment and with cranial critical-size defect; (GII-n = 5, 21 days or n = 5, 30 days) cranial critical-size defect filled with collagen sponge scaffold; (GIII-n = 5, 21 days or n = 5, 30 days) cranial critical-size defect submitted to low-level laser therapy; (GIV-n = 5, 21 days or n = 5, 30 days) cranial critical-size defect submitted to combined collagen sponge scaffold + low-level laser therapy treatment. In relation to the histological analysis, the collagen sponge scaffold + low-level laser therapy treatment group (GIV) 30 days showed the best result with the presence of secondary bone, immature bone (osteoid) and newly formed connective tissue (periosteum). GA-LDA model also successfully classified control class of the others classes. Thus, the results provided by the good-quality classification model revealed the feasibility of NIRS for application to evaluation of the wound healing in rat cranial defect, thanks to the short analysis time of a few seconds and nondestructive advantages of NIRS as an alternative approach for bone repair purposes. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 33:1160-1168, 2017.

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Influence of the λ780nm laser light on the repair of surgical bone defects grafted or not with biphasic synthetic micro-granular hydroxylapatite+Beta-Calcium triphosphate

Cited by 20 publications

References 22 publications

Repair of Surgical Bone Defects Grafted with Hydroxylapatite + β-TCP and Irradiated with λ=850 nm LED Light

Repair of Surgical Bone Defects Grafted with Hydroxylapatite + β-TCP and Irradiated with λ=850 nm LED Light

Biphasic, Triphasic, and Multiphasic Calcium Orthophosphates

Evaluation of the bony repair in rat cranial defect using near infrared reflectance spectroscopy and discriminant analysis

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