Influence of the Young’s Modulus of Polyurethane Implants on the Organism’s Immune Response

Kondyurina, Irina; Chudinov, V. S.; Terpugov, V. N.; Kondyurin, Alexey

doi:10.1007/s10527-019-09863-7

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…This mechanical property is a characteristic of the material and it can be measured with the elastic modulus or Young's modulus. It appears that implant materials with analogous Young's modulus to the one of the surrounding tissue can help avoid severe immune response 152 . Mismatch of Young's modulus at the biotic–abiotic interface is one of the fundamental driving forces in scar tissue formation 153 .…”

Section: Implant Properties Affect the Degree Of Host Responsementioning

confidence: 99%

“…It appears that implant materials with analogous Young's modulus to the one of the surrounding tissue can help avoid severe immune response. 152 Mismatch of Young's modulus at the biotic–abiotic interface is one of the fundamental driving forces in scar tissue formation. 153 Shear stress due to the stiffness of the material and micromotion in the brain, for example, damage the surrounding tissue resulting in enhanced proinflammatory cell activation, including reactive astrocytes.…”

Section: Implant Properties Affect the Degree Of Host Responsementioning

confidence: 99%

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Advanced strategies to thwart foreign body response to implantable devices

Capuani

Malgir

Chua

et al. 2022

Bioengineering & Transla Med

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Mitigating the foreign body response (FBR) to implantable medical devices (IMDs) is critical for successful long‐term clinical deployment. The FBR is an inevitable immunological reaction to IMDs, resulting in inflammation and subsequent fibrotic encapsulation. Excessive fibrosis may impair IMDs function, eventually necessitating retrieval or replacement for continued therapy. Therefore, understanding the implant design parameters and their degree of influence on FBR is pivotal to effective and long lasting IMDs. This review gives an overview of FBR as well as anti‐FBR strategies. Furthermore, we highlight recent advances in biomimetic approaches to resist FBR, focusing on their characteristics and potential biomedical applications.

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Section: Implant Properties Affect the Degree Of Host Responsementioning

confidence: 99%

Section: Implant Properties Affect the Degree Of Host Responsementioning

confidence: 99%

Advanced strategies to thwart foreign body response to implantable devices

Capuani

Malgir

Chua

et al. 2022

Bioengineering & Transla Med

View full text Add to dashboard Cite

show abstract

“…Polyurethane ( Figure 2 ) was synthesised from polypropylene glycol terminated by toluenediisocyanate (Aldrich, Macquarie Park, Australia) and polyoxitetramethylene (Aldrich) with a deficit of hydroxyl groups that gave 3D crosslinking of the macromolecules. The details of the synthesis were described elsewhere [ 11 ]. The synthesised polyurethane was swollen in heptane to remove all non-crosslinked molecules and then air-dried to the complete evaporation of heptane controlled by FTIR spectra.…”

Section: Methodsmentioning

confidence: 99%

Foreign Body Reaction (Immune Response) for Artificial Implants Can Be Avoided: An Example of Polyurethane in Mice for 1 Week

Kondyurina,

Kondyurin

2023

JFB

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Despite great success with artificial implants for the human body, modern implants cannot solve major health problems. The reason is an immune reaction of organisms to artificial implants, known as the foreign body reaction. We have found a way to avoid or decrease the foreign body reaction. The surface of an artificial implant is modified with condensed aromatic structures containing free radicals, which provide a covalent attachment of host proteins in a native conformation. The total protein coverage prevents the direct contact of immune cells with the implant surface, and the immune cells are not activated. As a result, the immune response of the organism is not generated, and the artificial implant is not isolated from the tissue; there is no collagen capsule, low activity of macrophages, low cell proliferation, and low inflammatory activity.

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“…Bunun yanı sıra 316L biyoinerttir ve dolayısıyla doku-implant etkileşimi ve kemikle bağ oluşturabilme yetisi yoktur. İmplantasyonu takiben doku, implantı fibröz kapsül içerisine alarak bir anlamda izole eder ve aralarındaki etkileşimi minimuma indirir [8,9]. Tüm bu etmenler göz önünde bulundurulduğunda gerek korozyon direncini artırmak gerek implant-doku etkileşimini geliştirmek ve gerekse de antibakteriyel özellikleri artırmak amacıyla bir yüzey kaplama yapılması önem arz etmektedir [7].…”

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Wear and Corrosion Behaviour of Copper Oxide Doped Hydroxyapatite Thin Film Layer Coated By PLD

Vangölü

2021

Fırat Üniversitesi Mühendislik Bilimleri Dergisi

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Öz: Canlı kemik ve implant arasındaki doğrudan bağ oluşumu olarak tanımlanan osseointegrasyonu iyileştirme ve malzeme üzerinde bakteri oluşumunu azaltma üzerine yapılan araştırmalar bilim dünyasının en güncel çalışmalarındandır. Osseointegrasyonu artırmada en çok kullanılan yöntemlerden biri hidroksiapatit kaplamalarken, bakteri oluşumunu azaltmada kullanılan yöntemler çeşitlilik göstermektedir. Bu yöntemlerden biri de antibakteriyel olduğu bilinen bakır oksitin hidroksiapatit içerisine gömüldüğü kaplamalardır. Bu çalışmada, 316L paslanmaz çelik yüzey üzerine darbeli lazer biriktirme (PLD) işlemi uygulanarak yüzeyde bakır içerikli hidroksiapatit ince film tabakası (HA/CuO) oluşturulmuştur. Kaplama işlemi sonrası işlemsiz ve kaplanmış numunelerin fosfat tamponlu tuz çözeltisi (PBS) ve yapay vücut sıvısı (SBF) içerisinde korozyon davranışları ve kuru ortam aşınma davranışları karşılaştırılmıştır. Yapısal karakterizasyonları taramalı elektron mikroskopu (SEM), X ışını kırınım cihazı (XRD) ve 3D profilometre kullanılarak gerçekleştirilmiştir.

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Influence of the Young’s Modulus of Polyurethane Implants on the Organism’s Immune Response

Cited by 3 publications

References 7 publications

Advanced strategies to thwart foreign body response to implantable devices

Advanced strategies to thwart foreign body response to implantable devices

Foreign Body Reaction (Immune Response) for Artificial Implants Can Be Avoided: An Example of Polyurethane in Mice for 1 Week

Wear and Corrosion Behaviour of Copper Oxide Doped Hydroxyapatite Thin Film Layer Coated By PLD

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