Foreign Body Reaction (Immune Response) for Artificial Implants Can Be Avoided: An Example of Polyurethane in Mice for 1 Week

Kondyurina, Irina; Kondyurin, Alexey

doi:10.3390/jfb14080432

Cited by 3 publications

(4 citation statements)

References 53 publications

(75 reference statements)

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“…The ESR spectra of the treated PU showed the appearance of unpaired electrons at carbon atoms located in the graphite clusters. Similar signals of unpaired electrons in graphite clusters were observed in PU [49], polyether ether ketone, and PE [48] treated by nitrogen ions in PIII. In this case, the signal of unpaired electrons in the EPR spectra was observed after longterm exposure of the treated PU to air at room temperature.…”

Section: Discussionsupporting

confidence: 74%

“…The sizes of graphite clusters on the surface of Pebax polyamide treated in PIIII with nitrogen ions with an energy of 20 keV were 1.5 nm, and with an energy of 30 keV, they were 1.8 nm [47]. The sizes of graphite clusters on the surface of PU treated in PIIII with nitrogen ions with an energy of 20 keV were 2.5 nm [49]. The size of graphitic clusters is important for the stabilisation of free radicals in the surface layer after ion beam treatment before a protein solution is applied.…”

Section: Discussionmentioning

confidence: 97%

“…Thus, we can assume that this type of treatment can be used to activate the surface of PU for biomedical applications such as non-rejected implants [49], microarray for analysis, improved cell adhesion devices [46], and other biomedical devices where the covalent adsorption of protein onto the surface is a key factor. The precursors for protein covalent attachment are not required.…”

Section: Discussionmentioning

confidence: 99%

“…An example of successful protein grafting is the result of eliminating a foreign body reaction in an organism by implanting a PIII-activated PU implant in an animal. This implant shows a significantly weakened rejection reaction and, in some cases, the absence of a foreign body reaction [49]. The grafted protein hides the surface of the PU implant from the immune cells, and the organism does not recognise the implant as a foreign body.…”

Section: Introductionmentioning

confidence: 98%

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Attachment of Fibrinogen on Ion Beam Treated Polyurethane

Chudinov,

Shardakov,

Kondyurina

et al. 2024

Biomimetics

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Protein-stable coverage of the artificial implant is a key problem for biocompatibility. In the present study, a protein layer was attached covalently to a polyurethane surface treated by an ion beam. A plasma system consisting of a vacuum chamber (0.8 Pa pressure) with a high voltage electrode powered by a short pulse (20 μS pulse duration and 200 Hz pulse repetition) generator was designed. Polyurethane with a formulation certified as a material for medical implants was treated by nitrogen ions with an energy of 20 keV and 5 × 1014–1016 ions/cm2 fluence range. Wettability measurements, X-ray photoelectron, Raman, Fourier transform infrared attenuated total reflection, and ellipsometry spectra showed a significant change in the structure of the surface layer of the treated polyurethane. The surface of the treated polyurethane contained a carbonised layer containing condensed aromatic clusters with terminal free radicals. The surface energy of polyurethane surface increased from 33 to 65 mJ/m2. The treated polyurethane surface became capable of adsorbing and chemically binding protein (fibrinogen). The designed system for ion beam treatment can be used for surface activation of biomedical polymer devices, where a total protein coverage is required.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Attachment of Fibrinogen on Ion Beam Treated Polyurethane

Chudinov,

Shardakov,

Kondyurina

et al. 2024

Biomimetics

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Foreign Body Reaction to Ion-Beam-Treated Polyurethane Implant

Chudinov,

Shardakov,

Litvinov

et al. 2024

Materials

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All artificial materials used for implantation into an organism cause a foreign body reaction. This is an obstacle for a number of medical technologies. In this work, we investigated the effect of high-energy ion bombardment on polyurethane for medical purposes and the reaction of body tissues to its insertion into the mouse organism. An analysis of the cellular response and shell thickness near the implant showed a decrease in the foreign body reaction for implants treated with high-energy ions compared to untreated implants. The decrease in the reaction is associated with the activation of the polyurethane surface due to the formation on the surface layer of condensed aromatic clusters with unbonded valences on the carbon atoms at the edges of such clusters and the covalent attachment of the organism’s own proteins to the activated surface of the implant. Thus, immune cells do not identify the implant surface coated with its own proteins as a foreign body. The deactivation of free valences at the edges of aromatic structures due to the storage of the treated implant before surgery reduces surface activity and partially restores the foreign body response. For the greatest effect in eliminating a foreign body reaction, it is recommended to perform the operation immediately after treating the implant with high-energy ions, with minimal contact of the treated surface with any materials.

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Harnessing the Interactions of Wound Exudate Cells with Dressings Biomaterials for the Control and Prognosis of Healing Pathways

Saberianpour,

Melotto,

Redhead

et al. 2024

Pharmaceuticals

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The global socioeconomic challenge generated by wounds requires an understanding of healing and non-healing pathways in patients. Also, the interactions occurring between the wound dressing biomaterials with cells relevant to the healing process have not been sufficiently investigated, thus neglecting the role that wound dressing composition can play in healing. Through the study of six cases of acute surgical wounds, the present work analyses the early (24 h post-surgery) interactions of biochemical and cellular components with (i) Atrauman, a device made of knitted woven synthetic polymeric fibre when used as a primary dressing, and (ii) Melolin, a hydrocolloid engineered as two layers of synthetic and cellulose non-woven fibres when used as a secondary dressing. A pathway towards healing could be observed in those cases where endoglin-expressing cells and M2 macrophages were retained by Atrauman fibres at the interface with the wound bed. On the contrary, cases where the secondary dressing Melolin absorbed these cell phenotypes in its mesh resulted in a slower or deteriorating healing process. The data obtained indicate that a subtraction of progenitor cells by Melolin may impair the healing process and that the analysis of the retrieved wound dressings for biomarkers expressed by cells relevant to wound healing may become an additional tool to determine the patient’s prognosis.

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Foreign Body Reaction (Immune Response) for Artificial Implants Can Be Avoided: An Example of Polyurethane in Mice for 1 Week

Cited by 3 publications

References 53 publications

Attachment of Fibrinogen on Ion Beam Treated Polyurethane

Attachment of Fibrinogen on Ion Beam Treated Polyurethane

Foreign Body Reaction to Ion-Beam-Treated Polyurethane Implant

Harnessing the Interactions of Wound Exudate Cells with Dressings Biomaterials for the Control and Prognosis of Healing Pathways

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