Influence of the TNF-αand TNF-βPolymorphisms upon Infectious Risk and Outcome in Surgical Intensive Care Patients

Abstract

The presence of the A allele at these polymorphic sites did not predispose critically ill surgical patients to either infection or septic shock.

Association between tumor necrosis factor-α promoter −308 A/G polymorphism and susceptibility to sepsis and sepsis mortality: A systematic review and meta-analysis

“…Figure 3 illustrates that there was no association between TNF2 and sepsis-related mortality with an odds ratio of 1.48 (95% confidence interval, 0.81-2.70; p ϭ .20). (27) Ϫ ϩ Ϫ ϩ Jessen et al (25) ϩ ϩ ϩ ϩ Sipahi et al (33) Ϫ ϩ Ϫ ϩ Garnacho et al (22) ϩ ϩ Ϫ ϩ Watanabe et al (37) ϩ ϩ Ϫ ϩ Nakada et al (29) Ϫ ϩ Ϫ ϩ Jaber et al (24) Ϫ ϩ ϩ ϩ Gordon et al (23) ϩ ϩ ϩ ϩ Barber et al (18) Ϫ ϩ Ϫ ϩ Zhang et al (39) Ϫ ϩ Ϫ ϩ Zhang et al (40) Ϫ ϩ Ϫ ϩ Treszl et al (36) Ϫ ϩ Ϫ Ϫ Schaaf et al (32) ϩ ϩ Ϫ ϩ Gallagher et al (21) ϩ Ϫ Ϫ ϩ Calvano et al (19) Ϫ ϩ ϩ ϩ O'Keefe et al (31) Ϫ ϩ Ϫ ϩ Majetschak et al (26) Ϫ ϩ Ϫ ϩ Waterer et al (38) Ϫ ϩ ϩ ϩ Appolini et al (17) Ϫ ϩ Ϫ Ϫ Tang et al (35) Ϫ ϩ Ϫ ϩ Nuntayanuwat et al (30) Ϫ ϩ Ϫ Ϫ Mira et al (28) Ϫ ϩ ϩ ϩ Dumon et al (20) Ϫ ϩ Ϫ ϩ Stuber et al (34) Ϫ Stratification by ethnicity indicated that the association between TNF2 polymorphism and susceptibility to sepsis may be more pronounced in Asians as compared with whites (Fig. 4).…”

Ethical considerations in the collection of genetic data from critically ill patients: What do published studies reveal about potential directions for empirical ethics research?

“…Thirty-seven studies (46.8% enrolling 12 409 patients) were conducted solely or partly in the United States,18,20,22,28,36–40,42,45,47,50,52,53,55,56,58,60–63,67–70,72,75,77,81,82,87,90–92,94,95 34 studies (43.0% enrolling 10 096 patients) were conducted exclusively or partly in Europe,16,19,23–27,29–35,43,44,46,48,49,54,57,59,65,66,73,74,78,80,83–86,89,93 and the remainder were conducted in Asia, South America or Australia 17,41,51,64,71,76,79,88. Forty-eight studies (60.8%) recruited subjects from single centers,17,18,22,24,26,27,29,31,33–42,44,47,50,52,53,55–58,60,61, 63,64,70,71,73,75–77,80–89,92 16 (20.2%) were multicenter,16,20,21,…”

Clinical Utility of Extracorporeal Cytokine Hemoadsorption Therapy: A Literature Review

“…This may be due to the broad clinical spectrum encompassed by a diagnosis of sepsis, to timing of therapy or patient-specific differences in the innate immune responses to infection [3]. Several genetic factors affect the course of sepsis [108,109], and single nucleotide polymorphisms can greatly affect the serum levels of cytokines such as TNF-α in individuals [110,111]. It is hardly surprising, therefore, that clinical outcomes following hemoadsorption therapy may vary greatly between patients.…”