Association between tumor necrosis factor-α promoter −308 A/G polymorphism and susceptibility to sepsis and sepsis mortality: A systematic review and meta-analysis

Teuffel, Oliver; Ethier, Marie‐Chantal; Beyene, Joseph; Sung, Lillian

doi:10.1097/ccm.0b013e3181b42af0

Cited by 86 publications

(78 citation statements)

References 68 publications

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“…It is believed that these SNPs may affect gene expression so as to predispose to the development of acne vulgaris, although in some cases [8] they may offer protection from this skin disorder. These SNPs are mainly linked with predisposition to severe infections [11,12] and to the development of metabolic syndrome in women [13]. Metabolic syndrome is also a common denominator of females suffering from polycystic ovary syndrome (PCOS) which is a common endocrine disorder mediated through hyperandrogenism [14].…”

Section: Introductionmentioning

confidence: 99%

Impact of TNF Haplotypes in the Physical Course of Acne Vulgaris

et al. 2013

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Background: The role of single-nucleotide polymorphisms (SNPs) of the TNF gene in acne vulgaris remains controversial. Methods: Genomic DNA was isolated from 185 patients with acne vulgaris and 165 healthy controls. SNPs at positions -376, -308 and -238 of the promoter region of TNF were defined. Results: The frequency of the GAG haplotype was greater among patients (16.8%) than among controls with borderline significance (9.7%, p = 0.059). Male carriers of haplotypes other than GGG presented acne vulgaris at a later age than carriers of the GGG haplotype. No effect of the GAG haplotype on the frequency of acne conglobata was found among women with polycystic ovary syndrome. Conclusions: Carriage of the GAG haplotype of TNF is linked with borderline susceptibility to acne vulgaris. The GGG haplotype is related with earlier disease onset in male patients.

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Section: Introductionmentioning

confidence: 99%

Impact of TNF Haplotypes in the Physical Course of Acne Vulgaris

et al. 2013

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“…The best studied SNP of TNF is rs1800629 leading to one A/G transition at −308 position of gene promoter. The significance of the carriage of this SNP had been fully clarified in one meta-analysis of 25 case-association studies (28). Results showed that carriage of A alleles was associated with susceptibility to sepsis but not with mortality.…”

Section: Cytokinesmentioning

confidence: 99%

The role of genetics and antibodies in sepsis

Giamarellos‐Bourboulis¹,

Opal²

2016

Ann. Transl. Med.

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“…Thus, although being a carrier of the SNP TNF-308A was shown to increase the risk of sepsis in a meta-analysis that included mostly adults and older children, 44 there is so far no evidence of any association between the SNP TNF-308 G/A and increased risk of sepsis during the neonatal period.…”

Section: Tnf-alpha Gene Polymorphismmentioning

confidence: 99%

Prediction of sepsis-related outcomes in neonates through systematic genotyping of polymorphisms in genes for innate immunity and inflammation: a narrative review and critical perspective

et al. 2013

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CONTEXT AND OBJECTIVE: Neonatal sepsis is associated with premature birth and maternal infection. Large-scale studies seek to define markers that identify neonates at risk of developing sepsis. Here, we examine whether the scientific evidence supports systematic use of polymorphism genotyping in cytokine and innate immunity genes, to identify neonates at increased risk of sepsis. DESIGN AND SETTING: Narrative literature review conducted at Fernandes Figueira Institute, Brazil. METHODS:The literature was searched in PubMed, Embase (Excerpta Medica Database), Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde), SciELO (Scientific Electronic Library Online) and Cochrane Library. From > 400,000 references, 548 were retrieved based on inclusion/exclusion criteria; 22 were selected for detailed analysis after quality assessment. RESULTS:The studies retrieved addressed the impact of gene polymorphisms relating to immune mechanisms (most often TNF-a, LT-a, IL-6, IL-1β, IL-1ra, L-selectin, CD14 and MBL) or inflammatory mechanisms (ACE and angiotensin II receptors; secretory PLA2; and hemostatic factors). Despite initial reports suggesting positive associations between specific polymorphisms and increased risk of sepsis, the accumulated evidence has not confirmed that any of them have predictive power to justify systematic genotyping. CONCLUSIONS: Sepsis prediction through systematic genotyping needs to be reevaluated, based on studies that demonstrate the functional impact of gene polymorphisms and epidemiological differences among ethnically distinct populations. RESUMO CONTEXTO E OBJETIVO:A sepse neonatal está associada ao parto prematuro e à infecção materna. Estudos em grande escala buscam marcadores que identifiquem neonatos em risco de desenvolver sepse. Examinamos aqui se a evidência científica apoia o uso sistemático de genotipagem dos polimorfismos em genes de citocinas e imunidade inata, para identificar neonatos com risco elevado de sepse. TIPO DE ESTUDO E LOCAL:Revisão narrativa da literatura, Instituto Fernandes Figueira, Brasil. MÉTODOS: Busca online da literatura foi feita no PubMed, Embase (Excerpta Medica Database), Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde), SciELO (Scientific Electronic Library Online) e Cochrane Library. De mais de 400.000 referências, 548 foram recuperadas com base nos critérios de inclusão/exclusão, e 22, selecionadas para análise detalhada após verificação da qualidade. RESULTADOS: Recuperamos estudos de impacto dos polimorfismos em genes relacionados com mecanismos imunes (mais frequentemente, TNF-a, LT-a, IL-6, IL-1β, IL-1ra, L-selectin, CD14, e MBL) ou inflamató-rios (ACE e receptores de angiotensina II; PLA2 secretória; fatores hemostáticos). Contrariando estudos que inicialmente sugeriram associação positiva entre polimorfismos específicos e risco aumentado de sepse, a evidência acumulada não confirmou, para qualquer deles, valor preditivo que justifique genotipagem sistemática para orientar antibioticoterapia. CONCLUSÕES: A...

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Association between tumor necrosis factor-α promoter −308 A/G polymorphism and susceptibility to sepsis and sepsis mortality: A systematic review and meta-analysis

Abstract: Our systematic review and meta-analysis demonstrates that the TNF2 polymorphism is associated with sepsis. However, TNF2 is not associated with sepsis mortality.

Cited by 86 publications

References 68 publications

Impact of TNF Haplotypes in the Physical Course of Acne Vulgaris

Impact of TNF Haplotypes in the Physical Course of Acne Vulgaris

The role of genetics and antibodies in sepsis

Prediction of sepsis-related outcomes in neonates through systematic genotyping of polymorphisms in genes for innate immunity and inflammation: a narrative review and critical perspective

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