Influence of the Stabilizer Concentration on the Internal Liquid Crystalline Order and the Size of Oil-Loaded Monolinolein-Based Dispersions

Abstract

The internal phase of monolinolein-based dispersions loaded with tetradecane or (R)-(+)-limonene was investigated as a function of the stabilizer content by small-angle X-ray scattering. Phase transitions at the colloidal scale were found in some of nanostructured aqueous dispersions by increasing the stabilizer content. For particles containing a bicontinuous cubic phase, a large increase of the stabilizer concentration promoted a liquid crystalline phase transition from the Pn3m to the Im3m cubic symmetry. The coexistence of both phases is observed in an intermediate stabilizer concentration range. For particles with an internal micellar cubic Fd3m symmetry, the internal structure changes in the isotropic fluid L(2) phase. In case of particles with an internal hexagonal phase (H(2) symmetry), the increasing amount of stabilizer did not alter the lattice parameter but decreased the size of the nanostructured domain. Moreover, we showed for hexagonal and emulsified micellar phase particles that the increase of the stabilizer content induced a strong decrease of the mean hydrodynamic size of the particles, allowing producing nanostructured lipid-based liquid crystalline particles down to a radius of 70 nm at the same energy input.

Lipid Self-Assemblies and Nanostructured Emulsions for Cosmetic Formulations

“…For instance, the internal self-assembly of nanostructured emulsions can be altered from cubic Pn3m to cubic Im3m by adding diglycerol monooleate or pluronic F127 to a DU lipid system [111,112]. The size of lipid nanoparticles can be modulated by changing the concentration of the dispersed phase and/or the shear rate of the shearing device [94].…”

Hierarchically Organized Systems Based on Liquid Crystalline Phases

“…In fact, the amphiphilic triblock copolymer, Pluronic F -127 (PEO 99 -PPO 67 -PEO 99 ), hereafter simply F -127, has been most widely used for structured emulsions such as ISAsomes (Guillot et al, 2010 ;Gustafsson et al, 1996Gustafsson et al, , 1997; nevertheless, polysaccharide -and polyethyleneglycol -based stabilizers (Huynh et al, 2009 ) are also used with varying levels of success. In fact, the amphiphilic triblock copolymer, Pluronic F -127 (PEO 99 -PPO 67 -PEO 99 ), hereafter simply F -127, has been most widely used for structured emulsions such as ISAsomes (Guillot et al, 2010 ;Gustafsson et al, 1996Gustafsson et al, , 1997; nevertheless, polysaccharide -and polyethyleneglycol -based stabilizers (Huynh et al, 2009 ) are also used with varying levels of success.…”

“…It is known that the addition of diglycerol monooleate, or F -127, converts Pn3m into Im3m (Guillot et al, 2010 ;Yaghmur et al, 2006a ), the latter also controls the size of the ISAsomes. It is known that the addition of diglycerol monooleate, or F -127, converts Pn3m into Im3m (Guillot et al, 2010 ;Yaghmur et al, 2006a ), the latter also controls the size of the ISAsomes.…”

“…Although surfactant stabilizers are widely used for stabilizing structured emulsions, including ISAsomes, they have certain disadvantages; for instance, they affect the nanostructure at higher surfactant concentrations (Guillot et al, 2010 ;Muller et al, 2010a ;Sagalowicz et al, 2006c ). Moreover, the most commonly used triblock copolymer, F -127, can actually penetrate the cubosomes to some extent and thereby infl uence (disrupt) the structure of at least their outer shell (Guillot et al, 2006(Guillot et al, , 2010Gustafsson et al, 1997 ).…”

The phase behaviour of mixed saturated and unsaturated monoglycerides in hydrophobic system

“…In the presence of water five additional phases are formed, fluid lamellar phase, three bicontinous cubic phases, Ia3d, Pn3 m and Im3 m and hexagonal phase (H 2 ) [14]. However, the phase diagrams of monoglyceride mixtures in the presence of different oil have been studied [15][16][17][18][19][20]. Otto Glatter's group found that the bulk phases of oil -loaded monoglyceride-basesd particles depend strongly on the amount of oil [21,22], and the size of the reverse micelles increases with alkyl chain length of oils [23].…”