Influence of the Selective Esrogen Receptor Modulators on the Expression and Synthesis of HSP 70 Proteins in Cardiomyocytes of Rats With Experimental Acute Myocard Infarction

Павлов, С. В.; Levchenko, K. V.; Nikitchenko, Yu. V.; Kamyshniy, O.M.; Робота, Дмитро Вадимович

doi:10.29256/v.02.01.2018.escbm09

Cited by 1 publication

(1 citation statement)

References 3 publications

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“…As a result of the binding of the ligand to the receptor, the conformation of the latter occurs, followed by the release of proteins from the ER-protein complex, which opens access to binding sites on the receptor for transcription and dimerization correlates (Wakade et al, 2008;Arevalo et al, 2011;Pavlov et al, 2017b). Studies have established the ability of tamoxifen to suppress nNOS, mediated through calmodulin, which reduces the production of NO and the accumulation of its damaging product peroxynitrite (Wakade et al, 2008;Paul and Mahanta, 2014;Pavlov et al, 2017b). In addition, 10.3389/fncel.2023.1131683 tamoxifen reduces the release of excitotoxic amino acids and acts as a scavenger of free radicals, preventing lipid peroxidation.…”

Section: Tamoxifenmentioning

confidence: 99%

Involvement of heat shock proteins HSP70 in the mechanisms of endogenous neuroprotection: the prospect of using HSP70 modulators

Беленичев

Aliyeva

Popazova

et al. 2023

Front. Cell. Neurosci.

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This analytical review summarizes literature data and our own research on HSP70-dependent mechanisms of neuroprotection and discusses potential pharmacological agents that can influence HSP70 expression to improve neurological outcomes and effective therapy. The authors formed a systemic concepts of the role of HSP70-dependent mechanisms of endogenous neuroprotection aimed at stopping the formation of mitochondrial dysfunction, activation of apoptosis, desensitization of estrogen receptors, reduction of oxidative and nitrosative stress, prevention of morpho-functional changes in brain cells during cerebral ischemia, and experimentally substantiated new target links for neuroprotection. Heat shock proteins (HSPs) are an evolutionarily integral part of the functioning of all cells acting as intracellular chaperones that support cell proteostasis under normal and various stress conditions (hyperthermia, hypoxia, oxidative stress, radiation, etc.). The greatest curiosity in conditions of ischemic brain damage is the HSP70 protein, as an important component of the endogenous neuroprotection system, which, first of all, performs the function of intracellular chaperones and ensures the processes of folding, holding and transport of synthesized proteins, as well as their degradation, both under normoxic conditions and stress-induced denaturation. A direct neuroprotective effect of HSP70 has been established, which is realized through the regulation the processes of apoptosis and cell necrosis due to a long-term effect on the synthesis of antioxidant enzymes, chaperone activity, and stabilization of active enzymes. An increase in the level of HSP70 leads to the normalization of the glutathione link of the thiol-disulfide system and an increase in the resistance of cells to ischemia. HSP 70 is able to activate and regulate compensatory ATP synthesis pathways during ischemia. It was found that in response to the cerebral ischemia formation, HIF-1a is expressed, which initiates the launch of compensatory mechanisms for energy production. Subsequently, the regulation of these processes switches to HSP70, which “prolongs” the action of HIF-1a, and also independently maintains the expression of mitochondrial NAD-dependent malate dehydrogenase activity, thereby maintaining the activity of the malate-aspartate shuttle mechanism for a long time. During ischemia of organs and tissues, HSP70 performs a protective function, which is realized through increased synthesis of antioxidant enzymes, stabilization of oxidatively damaged macromolecules, and direct anti-apoptotic and mitoprotective action. Such a role of these proteins in cellular reactions during ischemia raises the question of the development of new neuroprotective agents which are able to provide modulation/protection of the genes encoding the synthesis of HSP 70 and HIF-1a proteins. Numerous studies of recent years have noted the important role of HSP70 in the implementation of the mechanisms of metabolic adaptation, neuroplasticity and neuroprotection of brain cells, so the positive modulation of the HSP70 system is a perspective concept of neuroprotection, which can improve the efficiency of the treatment of ischemic-hypoxic brain damage and be the basis for substantiating of the feasibility of using of HSP70 modulators as promising neuroprotectors.

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Section: Tamoxifenmentioning

confidence: 99%

Involvement of heat shock proteins HSP70 in the mechanisms of endogenous neuroprotection: the prospect of using HSP70 modulators

Беленичев

Aliyeva

Popazova

et al. 2023

Front. Cell. Neurosci.

View full text Add to dashboard Cite

show abstract

Influence of the Selective Esrogen Receptor Modulators on the Expression and Synthesis of HSP 70 Proteins in Cardiomyocytes of Rats With Experimental Acute Myocard Infarction

Abstract: INFLUENCE OF THE SELECTIVE ESROGEN RECEPTOR MODULATORS ON THE EXPRESSION AND SYNTHESIS OF HSP 70 PROTEINS IN CARDIOMYOCYTES OF RATS WITH EXPERIMENTAL ACUTE MYOCARD INFARCTION

Cited by 1 publication

References 3 publications

Involvement of heat shock proteins HSP70 in the mechanisms of endogenous neuroprotection: the prospect of using HSP70 modulators

Involvement of heat shock proteins HSP70 in the mechanisms of endogenous neuroprotection: the prospect of using HSP70 modulators

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