Influence of the renal medulla and early treatment with enalapril upon the development of hypertension in young spontaneously hypertensive rats

Bergström, Göran; So, Bohman; Folkow, B; Göthberg, G; Rudenstam, J.; Karlström, Gunnar

doi:10.1097/00004872-199211000-00006

Cited by 7 publications

(8 citation statements)

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“…The therapeutic effects of ACEIs on hypertension have been demonstrated in a number of experiments. Bergstrom et al 9. demonstrated that the LV weight of SHRs treated with enalapril was significantly less than that of untreated SHRs.…”

Section: Discussionmentioning

confidence: 99%

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A comparative study of morphological changes in spontaneously hypertensive rats and normotensive Wistar Kyoto rats treated with an angiotensin-converting enzyme inhibitor or a calcium-channel blocker

Saleh

2001

J. Pathol.

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It is not clear whether some pathological changes in hypertension are directly pressure-dependent, or hormonally induced, or both. The aortic arch has apparently never before been studied for those changes. The aim of this study was to compare the effects of controlling angiotensin II (Ang II) and/or blood pressure (BP), directly at the inception of hypertension, on the aortic arch, the left ventricle of the heart (LV), and the kidneys of spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto (WKY) rats. An angiotensin-converting enzyme inhibitor (ACEI, enalapril) and a calcium-channel blocker (nifedipine) were used for 21 weeks. After treatment, rats were assessed for arterial plasma renin activity (PRA). The LV, aortic arch, and kidneys were then excised for the determination of organ and tissue weight in some of the animals, while in others the aortic arch was fixed in situ and processed for microscopic analysis. Both enalapril and nifedipine levelled BP in the SHRs to almost normal values. Enalapril was able to prevent the increase in LV and kidney weights (p=0.04 wet, p<0.001 dry; p<0.001 wet and dry, respectively) and the increase in the weight of the aortic arch and in the thickness of its media (p<0.001 wet and dry; p<0.001, respectively) seen in untreated SHRs. This was associated with a larger lumen diameter (p<0.001) and a lower media to lumen ratio (p=0.01). In contrast, nifedipine did not prevent any of the changes described. Neither nifedipine nor enalapril treatment had any effects on PRA in either rat strain. Our results support previous observations that BP is not the only factor causing some of the pathological changes in hypertension; tissue Ang II level may also play a major role.

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Section: Discussionmentioning

confidence: 99%

“…Essential hypertension could be accompanied by damage to target organs, namely cardiac hypertrophy and nephromegaly. Bergstrom et al 9. demonstrated a significantly higher LV weight in untreated SHRs.…”

Section: Introductionmentioning

confidence: 94%

A comparative study of morphological changes in spontaneously hypertensive rats and normotensive Wistar Kyoto rats treated with an angiotensin-converting enzyme inhibitor or a calcium-channel blocker

Saleh

2001

J. Pathol.

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“…Other observations indicate involvement of the kidney, particularly the renal medulla, in the process of resetting (Bergstrom et al 1992;Harrap et al 1994).…”

Section: Discussionmentioning

confidence: 99%

“…Other studies have demonstrated that removal of the renal medulla during ACE inhibitor treatment also prevents any long-term reduction in blood pressure (Bergstrom et al 1992).…”

Section: Introductionmentioning

confidence: 99%

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Renal Medulla and Bradykinin During the Development of Hypertension in SHR

O’Sullivan

Bertram

Harrap

1995

Clin Exp Pharma Physio

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1. The long-term reduction in blood pressure following ACE inhibitor treatment in young spontaneously hypertensive rats (SHR) appears to depend on both the kidney and bradykinin. 2. The aim of this experiment was to examine the effects of ACE inhibition and bradykinin on renal morphology and blood pressure in SHR. 3. Between 6 and 10 weeks of age male SHR received one of four treatments: water (n = 26), ramipril (1 mg/kg per day; n = 24), ramipril (1 mg/kg per day) plus Hoe 140 (0.5 mg/kg per day; n = 25) or Hoe 140 (0.5 mg/kg per day; n = 25). 4. Renal medullary and cortical volumes were determined stereologically at 10 and 20 weeks of age. 5. After 4 weeks of treatment, ramipril reduced the size of the renal medulla while Hoe 140 increased medullary volumes compared to control. Ten weeks after treatment was stopped the renal medulla of the ramipril group had returned to normal, however, there was a persistent increase in medullary volume of both Hoe 140 treated groups. 6. Our results imply that bradykinin may influence the size of the renal medulla which may have important effects on the development of hypertension in SHR.

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Adaptation of the kidney to protein intake and to urine concentrating activity: Similar consequences in health and CRF

Bankir¹,

Kriz²

1995

Kidney International

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Influence of the renal medulla and early treatment with enalapril upon the development of hypertension in young spontaneously hypertensive rats

Cited by 7 publications

References 0 publications

A comparative study of morphological changes in spontaneously hypertensive rats and normotensive Wistar Kyoto rats treated with an angiotensin-converting enzyme inhibitor or a calcium-channel blocker

A comparative study of morphological changes in spontaneously hypertensive rats and normotensive Wistar Kyoto rats treated with an angiotensin-converting enzyme inhibitor or a calcium-channel blocker

Renal Medulla and Bradykinin During the Development of Hypertension in SHR

Adaptation of the kidney to protein intake and to urine concentrating activity: Similar consequences in health and CRF

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