Influence of the Poly(ethylene Glycol) Methyl Ether Methacrylates on the Selected Physicochemical Properties of Thermally Sensitive Polymeric Particles for Controlled Drug Delivery

Abstract

Thermosensitive copolymers P1–P5 of N-isopropylacrylamide (NIPA) and poly(ethylene glycol) methyl ether methacrylates (PEGMEMs) were synthesized via surfactant-free precipitation polymerization (SFPP) using ammonium persulfate (APS) at 70 °C. The polymerization course was evaluated by the conductivity. The hydrodynamic diameters and the polydispersity indexes (PDI) of P1–P5 in the 18–45 °C range, which were assessed via dynamic light scattering (DLS), were at 18° (nm): 26.07 ± 0.54 (PDI 0.65 ± 0.03), 68.00 ± 1.10 (PDI 0.56 ± 0,02), 45.12 ± 0.57 (PDI 0.51 ± 0.03), 62.78 ± 0.40 (PDI 0.53 ± 0.003), and 92.95 ± 1.56 (PDI 0.60 ± 0.04), respectively. The lower critical solution temperatures ranged from 31 to 33 ℃. The electrophoretic mobilities estimated the zeta potential in the 18–45 °C range, and at 18 °C, they were (mV): −4.64 ± 1.30, −6.91 ± 2.67, −5.85 ± 3.17, −2.28 ± 0.30, and −3.60 ± 0.96 for P1–P5, respectively. The polymers were characterized by Attenuated Total Reflectance Fourier-Transform Infrared spectroscopy (ATR-FTIR), H nuclear magnetic resonance (1H NMR), thermogravimetric analysis (TGA/DTA), Differential Scanning Calorimetry (DSC), and powder X-ray diffraction analysis (PXRD). Stable amorphous polymers were obtained. We conclude that the length of the co-monomer chain nonlinearly influences the properties of the obtained thermosensitive polymer nanostructures.

Investigation of the Effect of Poly[poly(ethylene glycol) methyl ether methacrylate] Addition on the Electrochemical Performance of Cellulose-Based Solid- and Gel-Polymer Electrolytes in Lithium-Ion Batteries

“…28,30 Additionally, the appearance of distinct peaks at 0.88 ppm (a) and 1. 31,32 This confirmed that all steps of synthesis were done successfully. Also, the ratio of PEGMA to cellulose was determined by using the integral calculation under the peak of about 1.2 ppm for poly-(PEGMA) and about 4 ppm for cellulose.…”

“…The comparison of signal intensities in the 1 H NMR spectra provides further evidence for the formation of ester bonds between cellulose –OH groups and DDMAT carboxyl (–COOH) groups. The results showed after polymerization by PEGMA, the poly­(PEGMA) peaks at (a) 1.2 ppm, (b) 1.8 ppm, (c) 3.4–3.5 ppm, and (d) 3.3 ppm. , This confirmed that all steps of synthesis were done successfully. Also, the ratio of PEGMA to cellulose was determined by using the integral calculation under the peak of about 1.2 ppm for poly­(PEGMA) and about 4 ppm for cellulose.…”

Temperature-Insensitive Nonpolar Suspensions of Polyoxyethylene Alkyl Ether-Grafted Silica Nanoparticles

“…To obtain temperature-insensitive nonpolar suspensions, it is necessary to simultaneously prevent high-temperature-induced desorption and low-temperature-induced ordered conformation of the modifiers. In addition to introducing branched polyesters and unsaturated stearic acid to the modifiers, flexible ethylene oxide (EO) chains − have the potential to disrupt the ordered conformation of a modifier at low temperatures, , which can reduce the low-temperature sensitivity of the resulting nonpolar suspensions.…”

The advance anticancer role of polymeric core‐shell ZnO nanoparticles containing oxaliplatin in colorectal cancer

“…In particular, micelles constructed of amphiphilic block polymers such as PEGMA have been widely studied in drug administration with the goal of tumor‐targeted theranostics. [ 23–35 ] Polymeric nanocomposites containing zinc oxide can help prepare biocompatible nanoparticles and effectively deliver chemotherapy drugs to cancer cells. Many studies have shown that Zinc oxide nanoparticles can be used to provide chemotherapy agents as a cancer treatment.…”

“…In particular, micelles constructed of amphiphilic block polymers such as PEGMA have been widely studied in drug administration with the goal of tumor-targeted theranostics. [23][24][25][26][27][28][29][30][31][32][33][34][35] Polymeric nanocomposites containing zinc oxide can help prepare biocompatible nanoparticles and effectively deliver chemotherapy drugs to cancer cells.…”