Influence of the Photostabilizer in the Photoprotective Effects of a Formulation Containing UV‐Filters and Vitamin A

Benevenuto, Carolina Gomes; Matteo, Miguel Angel Sala Di; Campos, Patrícia Maria Berardo Gonçalves Maia; Gaspar, Lorena Rigo

doi:10.1111/j.1751-1097.2010.00806.x

Cited by 10 publications

(11 citation statements)

References 26 publications

(43 reference statements)

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“…Benevenuto et al . [ 27 ] also showed that formulations containing vitamin A palmitate with UV-filters combined with some photostabilizers had better protective effects on hairless mice skin than the ones without any photostabilizer. Considering that many cosmetic formulations contain combinations of vitamins, the results in the present study could also contribute to the development of more stable formulations.…”

Section: Resultsmentioning

confidence: 99%

Benefits of Combinations of Vitamin A, C and E Derivatives in the Stability of Cosmetic Formulations

et al. 2012

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Chemically stable ester derivatives of vitamins A, C and E have become a focus of interest for their role in the satisfactory results in skin aging treatments. Accordingly, the aim of this study was to evaluate the physical and chemical stability of a cosmetic formulation containing 1% retinyl palmitate, ascorbyl tetraisopalmitate and tocopheryl acetate, alone or in combination. In the studies of physical stability, a Brookfield rheometer was used to determine rheological behavior of formulations containing the vitamins. Chemical stability was determined by HPLC on a Shimadzu system with UV detection. Results showed that formulations had pseudoplastic behavior and that vitamins did not alter their apparent viscosity and thixotropy. In the chemical stability studies, first-order reaction equations were used for determinations of the shelf-life of vitamins derivatives considering a remaining concentration of 85%. Combined vitamins in a single formulation had a slightly lower degradation rate as compared to different preparations containing only one of the vitamins. Considering that many cosmetic formulations contain vitamin combinations it is suggested that the present study may contribute to the development of more stable formulations containing liposoluble vitamins.

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Section: Resultsmentioning

confidence: 99%

Benefits of Combinations of Vitamin A, C and E Derivatives in the Stability of Cosmetic Formulations

et al. 2012

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“…To manage the photostability of avobenzone, thus ensuring maximum efficiency, a variety of photostabilizers are typically combined with it, including other UV filters such octocrylene as illustrated in Fig. b , and excited state quenchers such as diethylhexyl 2,6‐naphthalate and ethylhexyl methoxycrylene . Whereas these formulation developments reduce photo‐degradation, they do not completely eliminate it.…”

Section: Overview Of Sunscreen Product Formulationmentioning

confidence: 99%

Relevance of UV filter/sunscreen product photostability to human safety

Nash

Tanner

2014

Photoderm Photoimm Photomed

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Summary Photostability or photo‐instability of sunscreen products is most often discussed in undesirable terms with respect to human safety. The health risks, specifically associated with sunscreens, photostable or photo‐unstable, include phototoxic/photoirritation or photoallergic responses and, longer‐term, an increased risk of skin cancers or photoageing. The aims of this paper are to define photostability/photo‐instability and objectively assess the acute and chronic toxicological consequences from the human exposure to UV filter/sunscreens and any probable photo‐degradation products. The reported prevalence of photoirritation and photoallergic responses to sunscreens is rare compared with adverse events, for example, skin irritation or sensitization, produced by cosmetics or topically applied drugs and do not directly implicate potential photo‐degradation products of UV filters. Moreover, for at least one photo‐unstable combination, octyl methoxycinnamate and avobenzone, the long‐term benefits to humans, i.e., reduction in skin cancers, seem to outweigh any potential adverse consequences attributed to photo‐degradation. Sunscreen products are formulated to achieve maximum efficacy which, by necessity and design, incorporate measures to support and promote photostability since all organic UV filters have the potential to photo‐degrade. Current performance measures, in vivo SPF and in vitro UVA, conducted under standardized conditions, in part account for photostability. The concerns expressed when considering human exposure to potential photo‐unstable UV filters or sunscreen products may not manifest as health risks under conditions of use. Still, improvement in sunscreen product photostability continues to be a key strategic objective for manufacturers.

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“…Among antioxidant activity assays, the chemiluminescence method is described by many authors as a sensitive assay to detect levels of free radicals as well as screen in vitro antioxidant activity (13). The in vivo photoprotective evaluation can be assessed as the ability of a substance to reduce UV-induced skin damage, such as erythema, compromised skin-barrier function and sunburn cell (apoptotic cell) formation when applied to hairless mouse skin before UVA ⁄ UVB irradiation (13,14). Clinical studies have been frequently used in dermatology and cosmetic areas; however, they are only qualitative.…”

Section: Introductionmentioning

confidence: 99%

“…Fifteen minutes after the last application of the formulations, mice were immobilized and exposed to UVA/UVB radiation from an Oriel 150 W Xenon arc solar simulator (Oriel Corporation, Stratford, CT). Irradiance at dorsal skin level (20 cm from the source) was ca 0.399 mW cm −2 UVB (measured at 290 nm) as calculated with a 70260 Oriel Radiant Power Meter equipped with a silicon probe and U‐340 filter, (13,14,18). Mice were irradiated for 9 min, which resulted in a cumulative UVB dose of ca 215.46 mJ cm −2 or 10.3 MED cm −2 .…”

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Efficacy of Cosmetic Formulations Containing Dispersion of Liposome with Magnesium Ascorbyl Phosphate, Alpha‐Lipoic Acid and Kinetin

Campos¹,

Júnior

Andrade

et al. 2012

Photochem & Photobiology

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The present study aimed to evaluate the photoprotective effects of cosmetic formulations containing a dispersion of liposome with magnesium ascorbyl phosphate (MAP), alpha-lipoic acid (ALA) and kinetin, as well as their effects on the hydration and viscoelastic skin properties. The photoprotection was determined in vitro (antioxidant activity) and in vivo on UV-irradiated hairless mouse skin. The hydration effects were performed with the application of the formulations under study on the forearm of human volunteers and skin conditions were analyzed before and after a single application and daily applications during 4 weeks in terms of transepidermal water loss (TEWL), skin moisture and viscoelastic properties. The raw material under study possessed free-radical scavenging activity and the formulation with it protected hairless mouse skin barrier function against UV damage. After 4 weeks of application on human skin, the formulation under study enhanced stratum corneum skin moisture and also showed hydration effects in deeper layers of the skin. Thus, it can be concluded that the cosmetic formulation containing a dispersion of liposome with MAP, ALA and kinetin under study showed photoprotective effects in skin barrier function as well as pronounced hydration effects on human skin, which suggests that this dispersion has potential antiaging effects.

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Influence of the Photostabilizer in the Photoprotective Effects of a Formulation Containing UV‐Filters and Vitamin A

Cited by 10 publications

References 26 publications

Benefits of Combinations of Vitamin A, C and E Derivatives in the Stability of Cosmetic Formulations

Benefits of Combinations of Vitamin A, C and E Derivatives in the Stability of Cosmetic Formulations

Relevance of UV filter/sunscreen product photostability to human safety

Efficacy of Cosmetic Formulations Containing Dispersion of Liposome with Magnesium Ascorbyl Phosphate, Alpha‐Lipoic Acid and Kinetin

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