Efficacy of Cosmetic Formulations Containing Dispersion of Liposome with Magnesium Ascorbyl Phosphate, Alpha‐Lipoic Acid and Kinetin

Abstract

The present study aimed to evaluate the photoprotective effects of cosmetic formulations containing a dispersion of liposome with magnesium ascorbyl phosphate (MAP), alpha-lipoic acid (ALA) and kinetin, as well as their effects on the hydration and viscoelastic skin properties. The photoprotection was determined in vitro (antioxidant activity) and in vivo on UV-irradiated hairless mouse skin. The hydration effects were performed with the application of the formulations under study on the forearm of human volunteers and skin conditions were analyzed before and after a single application and daily applications during 4 weeks in terms of transepidermal water loss (TEWL), skin moisture and viscoelastic properties. The raw material under study possessed free-radical scavenging activity and the formulation with it protected hairless mouse skin barrier function against UV damage. After 4 weeks of application on human skin, the formulation under study enhanced stratum corneum skin moisture and also showed hydration effects in deeper layers of the skin. Thus, it can be concluded that the cosmetic formulation containing a dispersion of liposome with MAP, ALA and kinetin under study showed photoprotective effects in skin barrier function as well as pronounced hydration effects on human skin, which suggests that this dispersion has potential antiaging effects.

Zn(II)-Chlorido Complexes of Phytohormone Kinetin and Its Derivatives Modulate Expression of Inflammatory Mediators in THP-1 Cells

“…In addition to the regulatory functions in plants, kinetin has also showed strong anti-ageing activity on different animal targets, such as fruit flies [3], or human dermal cells [4], [5]. These positive effects led to the commercial application of kinetin in rejuvenating medicinal cosmetics [6], [7].…”

Preparation and characterization of glycyrrhetinic‐acid loaded PEG‐modified liposome based on PEG‐7 glyceryl cocoate

“…As shown in Fig. 4, the cumulative permeation rate of GA in the solution was faster than both liposomes, while the nonmodified liposomes were nearly the same as the PEG-modified ones in the first 24 h and a little faster in the last 24 h, this may related to the controlled release properties of liposomes [25,26].…”

Assessment of cubosomal alpha lipoic acid gel efficacy for the aging face: a single‐blinded, placebo‐controlled, right‐left comparative clinical study

“…ALA's ability to inhibit apoptosis of endothelial cells could beneficially affect endothelial dysfunction, which accompanies the aging manifestations. Photo‐protective effect as well as pronounced hydration effect on the skin induced by an ALA‐containing formulation could add to its efficacy …”