Influence of the periprostatic adipose tissue in obesity-associated mouse urethral dysfunction and oxidative stress: Effect of resveratrol treatment

Alexandre, Eduardo C.; Calmasini, Fabiano Beraldi; Sponton, Amanda Christine da Silva; Oliveira, Mariana Gonçalves de; André, Diana Majolli; Silva, Fábio H.; Delbin, Maria Andréia; Mónica, Fabíola Z.; Antunes, Edson

doi:10.1016/j.ejphar.2018.08.010

Cited by 10 publications

(7 citation statements)

References 39 publications

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“…In obese mice, the area of PPAT and the gene expression for NADPH oxidase 2 (NOX 2) and TNF-α were all higher than in the lean mice. Although this study did not evaluate the impact of PPAT on the prostate, it strongly suggests that PPAT may release pro-inflammatory and pro-oxidant substances that could interfere in prostate contractility (Alexandre et al, 2018).…”

Section: Relationship Between Periprostatic Adipose Tissue and Prosta...mentioning

confidence: 94%

“…The presence of PPAT was along 48% of the prostate surface, of that 57-59% present PPAT on the right and lateral surface and 44% and 36% along the anterior and posterior region, respectively (Hong et al, 2003). PPAT can have similar characteristics to PVAT by releasing pro-inflammatory cytokines (resistin, IL-6, TNF-α, MCP-1, chemerin, progranulin) (Blüher 2013;Alexandre et al, 2018), growth factors (progranulin and chemerin) (Klöting et al, 2010), contractile (angiotensin II, superoxide generation) (Lu et al, 2010) and anti-contractile (leptin, adiponectin, H 2 O 2 , ADRF and NO) (Victorio et al, 2016;Araujo et al, 2018) substances (Figure 1B).…”

Section: Relationship Between Periprostatic Adipose Tissue and Prosta...mentioning

confidence: 99%

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The Role of Periprostatic Adipose Tissue on Prostate Function in Vascular-Related Disorders

et al. 2021

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The lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) are highly prevalent worldwide. Clinical and experimental data suggest that the incidence of LUTS-BPH is higher in patients with vascular-related disorders such as in pelvic ischemia, obesity and diabetes as well as in the ageing population. Obesity is an important risk factor that predisposes to glucose intolerance, insulin resistance, dyslipidemia, type 2 diabetes mellitus and cardiovascular disorders. Prospective studies showed that obese men are more likely to develop LUTS-BPH than non-obese men. Yet, men with greater waist circumferences were also at a greater risk of increased prostate volume and prostate-specific antigen than men with lower waist circumference. BPH is characterized by an enlarged prostate and increased smooth muscle tone, thus causing urinary symptoms. Data from experimental studies showed a significant increase in prostate and epididymal adipose tissue weight of obese mice when compared with lean mice. Adipose tissues that are in direct contact with specific organs have gained attention due to their potential paracrine role. The prostate gland is surrounded by periprostatic adipose tissue (PPAT), which is believed to play a paracrine role by releasing growth factors, pro-inflammatory, pro-oxidant, contractile and anti-contractile substances that interfere in prostate reactivity and growth. Therefore, this review is divided into two main parts, one focusing on the role of adipokines in the context of obesity that can lead to LUTS/BPH and the second part focusing on the mediators released from PPAT and the possible pathways that may interfere in the prostate microenvironment.

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Section: Relationship Between Periprostatic Adipose Tissue and Prosta...mentioning

confidence: 94%

Section: Relationship Between Periprostatic Adipose Tissue and Prosta...mentioning

confidence: 99%

The Role of Periprostatic Adipose Tissue on Prostate Function in Vascular-Related Disorders

et al. 2021

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“…Alexandre et al ( 204 ) have reported higher levels of ROS, along with decreased levels of NO and SOD in the urethral smooth muscle of obese mice. All these abnormalities are reversed by treatment with resveratrol ( 204 ). In a streptozotocin-induced diabetic rat model, urethral dysfunction was associated with increased OS markers, decreased activity of antioxidant enzymes, along with the downregulation of nNOS, NO, and cGMP ( 197 ).…”

Section: Impact Of Oxidative Stress On the Lower Urinary Tractmentioning

confidence: 98%

“…Enhanced OS coupled with increased collagen deposition has been observed in rats with castration, and the changes can be attenuated by alpha-tocopherol supplementation (203). Alexandre et al (204) have reported higher levels of ROS, along with decreased levels of NO and SOD in the urethral smooth muscle of obese mice. All these abnormalities are reversed by treatment with resveratrol (204).…”

Section: Impact Of Oxidative Stress On the Urethramentioning

confidence: 99%

Oxidative Stress: A Putative Link Between Lower Urinary Tract Symptoms and Aging and Major Chronic Diseases

Elrashidy

et al. 2022

Front. Med.

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Aging and major chronic diseases are risk factors for lower urinary tract symptoms (LUTS). On the other hand, oxidative stress (OS) is one of the fundamental mechanisms of aging and the development of chronic diseases. Therefore, OS might be a candidate mechanism linking these two clinical entities. This article aims to summarize the studies on the prevalence of LUTS, the role of OS in aging and chronic diseases, and the potential mechanisms supporting the putative link. A comprehensive literature search was performed to identify recent reports investigating LUTS and OS in major chronic diseases. In addition, studies on the impact of OS on the lower urinary tract, including bladder, urethra, and prostate, were collected and summarized. Many studies showed LUTS are prevalent in aging and major chronic diseases, including obesity, metabolic syndrome, diabetes, cardiovascular disease, hypertension, obstructive sleep apnea, autoimmune diseases, Alzheimer’s disease, and Parkinson’s disease. At the same time, OS is a key component in the pathogenesis of those chronic diseases and conditions. Recent studies also provided evidence that exacerbated OS can cause functional and/or structural changes in the bladder, urethra, and prostate, leading to LUTS. The reviewed data support the concept that OS is involved in multiple risk factors-associated LUTS, although further studies are needed to confirm the causative relationship. The specific ROS/RNS and corresponding reactions/pathways involved in chronic diseases and associated LUTS should be identified in the future and could serve as therapeutic targets.

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“…Obesity results from increasing the size and volume of body fat cells and has adverse effects on the health of living organisms [76,77]. On the other hand, the mismatch between height and body weight due to excessive fat accumulation is named obesity [78]. Today, the people of developed countries are facing obesity-related health problems, but the people of developing countries are grappling with this global dilemma [79].…”

Section: Metabolic Disorders In Atmentioning

confidence: 99%

A Brief Overview of Oxidative Stress in Adipose Tissue with a Therapeutic Approach to Taking Antioxidant Supplements

Taherkhani

Ruhee

2021

Antioxidants

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One of the leading causes of obesity associated with oxidative stress (OS) is excessive consumption of nutrients, especially fast-foods, and a sedentary lifestyle, characterized by the ample accumulation of lipid in adipose tissue (AT). When the body needs energy, the lipid is broken down into glycerol (G) and free fatty acids (FFA) during the lipolysis process and transferred to various tissues in the body. Materials secreted from AT, especially adipocytokines (interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α)) and reactive oxygen species (ROS), are impressive in causing inflammation and OS of AT. There are several ways to improve obesity, but researchers have highly regarded the use of antioxidant supplements due to their neutralizing properties in removing ROS. In this review, we have examined the AT response to OS to antioxidant supplements focusing on animal studies. The results are inconsistent due to differences in the study duration and diversity in animals (strain, age, and sex). Therefore, there is a need for different studies, especially in humans.

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Influence of the periprostatic adipose tissue in obesity-associated mouse urethral dysfunction and oxidative stress: Effect of resveratrol treatment

Cited by 10 publications

References 39 publications

The Role of Periprostatic Adipose Tissue on Prostate Function in Vascular-Related Disorders

The Role of Periprostatic Adipose Tissue on Prostate Function in Vascular-Related Disorders

Oxidative Stress: A Putative Link Between Lower Urinary Tract Symptoms and Aging and Major Chronic Diseases

A Brief Overview of Oxidative Stress in Adipose Tissue with a Therapeutic Approach to Taking Antioxidant Supplements

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