2022
DOI: 10.3389/fmed.2022.812967
|View full text |Cite
|
Sign up to set email alerts
|

Oxidative Stress: A Putative Link Between Lower Urinary Tract Symptoms and Aging and Major Chronic Diseases

Abstract: Aging and major chronic diseases are risk factors for lower urinary tract symptoms (LUTS). On the other hand, oxidative stress (OS) is one of the fundamental mechanisms of aging and the development of chronic diseases. Therefore, OS might be a candidate mechanism linking these two clinical entities. This article aims to summarize the studies on the prevalence of LUTS, the role of OS in aging and chronic diseases, and the potential mechanisms supporting the putative link. A comprehensive literature search was p… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
7
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 11 publications
(7 citation statements)
references
References 214 publications
0
7
0
Order By: Relevance
“…Additionally, it can provide more ideas for exploring the mechanisms of ageing. Research has suggested that the mechanisms of bladder ageing are complex, with hypoxia, oxidative stress and inflammatory responses playing a role in ageing-associated bladder dysfunction [ 37 39 ]. However, recent studies have suggested that inflammatory ageing is a significant mechanism for ageing-associated bladder dysfunction [ 38 41 ].…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, it can provide more ideas for exploring the mechanisms of ageing. Research has suggested that the mechanisms of bladder ageing are complex, with hypoxia, oxidative stress and inflammatory responses playing a role in ageing-associated bladder dysfunction [ 37 39 ]. However, recent studies have suggested that inflammatory ageing is a significant mechanism for ageing-associated bladder dysfunction [ 38 41 ].…”
Section: Discussionmentioning
confidence: 99%
“…OAB is a complex, multifactorial symptom syndrome, 22 and OAB associated with metabolic syndrome has gained a lot of attention recently 23 . It arises from increased vesical afferent and efferent activity, oxidative stress‐related abnormalities, dysregulation of nutrient‐sensing pathways, and gut as well as bladder dysbiosis 22‐25 . Moreover, metabolic syndrome may further deteriorate bladder hypoperfusion secondary to BPH 23 .…”
Section: Discussionmentioning
confidence: 99%
“…23 It arises from increased vesical afferent and efferent activity, oxidative stressrelated abnormalities, dysregulation of nutrient-sensing pathways, and gut as well as bladder dysbiosis. [22][23][24][25] Moreover, metabolic syndrome may further deteriorate bladder hypoperfusion secondary to BPH. 23 Therefore, it is conceivable that metabolic syndrome might affect the persistence of OAB as well as de novo OAB.…”
Section: Age-specific Impact Of Holep On Oabmentioning
confidence: 99%
“…[ 6 ] Aging is one main reason accounting for LUTS because of the structural and functional changes in lower urinary tracts of the elderly. [ 7 ] What is more, LUTS caused by some chronic diseases including obesity, metabolic syndrome, diabetes, obstructive sleep apnea, etc., is quite prevalent in children and young adults, [ 8 ] and some people with congenital neurological diseases or bladder dysfunction may even suffer from this issue in their lifetime. [ 7 ] Because of the troublesome symptoms like urinary incontinence, urinary frequency, urgency, nocturia, bladder pain, and so on, the quality of life of the LUTS patients will be greatly influenced.…”
Section: Introductionmentioning
confidence: 99%