Influence of the nonsulfhydryl angiotensin-converting enzyme inhibitor trandolapril on lipid and carbohydrate metabolism related to exercise capacity in healthy subjects

Integrated effects of the vasodilating beta-blocker nebivolol on exercise performance, energy metabolism, cardiovascular and neurohormonal parameters in physically active patients with arterial hypertension

“…5,6 Particularly in the treatment of essential hypertension, physical exercise has become established as an effective therapeutic approach. [7][8][9][10] Positive effects of controlled exercise programmes in hypertensive subjects have been reported to include a reduction in systolic and diastolic blood pressure, [11][12][13] improvements of blood lipid profile and insulin sensitivity of the working skeletal muscle, [14][15][16][17] restoration of endothelial function, 18 a shift of the autonomic balance towards parasympathetic tone 19 and an improvement in quality of life. 20 However, if non-pharmacological measures alone fail to lower blood pressure to a normal level according to WHO/ISH guidelines, 21 additional antihypertensive drug treatment is necessary.…”

“…32 Further evidence of the neutral effects of nebivolol on the various energy metabolism parameters comes from the observation of unaltered lactate dynamics during maximal exercise under treatment.…”

“…12,33 Neutral metabolic effects at rest and during exercise similar to those observed with nebivolol have been reported for ACE inhibitors, calcium channel antagonists and alpha-1-receptor blockers. 8 In contrast, some beta receptor blockers, especially those of the first and second generation, and diuretics, at least if administered at higher dose levels, are characterised by unfavourable effects on the metabolic profile. 34,35 In summary, taking the limitations of an open label trial into account, monotherapy with the vasodilating ␤-1 selective beta-blocker nebivolol appears to be a suitable therapeutic option for physically active patients with mild-to-moderate essential hypertension.…”