Integrated effects of the vasodilating beta-blocker nebivolol on exercise performance, energy metabolism, cardiovascular and neurohormonal parameters in physically active patients with arterial hypertension

Hg, Predel; Mainka, W.; Schillings, Wendy J.; Knigge, H; Montiel, Juan de Dios Roldán; Fallois, J. von; Agrawal, Rahul; Schramm, Tina Ken; Gräf, Christine; Giannetti, B. M.; Bjarnason-Wehrens, Birna; Prinz, U; Rost, R.

doi:10.1038/sj.jhh.1001257

Cited by 34 publications

(11 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Neurohormonal, vascular, and structural adaptation mechanisms seem to be triggered by physical exercise and involved in the lowering effect of BP (Predel et al, 2001). Shah et al (2016), considering a cohort of more than 4,000 young adults followed for an average of 26.9 years, have highlighted the importance of cardiorespiratory fitness as an independent risk factor for CVDs, and found a reduction of 15% of total mortality and 12% of the first cardiovascular event in three decades for each minute of exercise.…”

Section: Discussionmentioning

confidence: 99%

Anxiety, Stress-Related Factors, and Blood Pressure in Young Adults

et al. 2016

View full text Add to dashboard Cite

Hypertension (HT) is a long-term medical condition characterized by persistently elevated blood pressure (BP) in the arterial vessels. Although HT initially is an asymptomatic condition, it chronically evolves into a major risk factor for cardiovascular, cerebrovascular, and renal diseases that, in turn, represent crucial causes of morbidity and mortality in industrialized countries. HT is a complex disorder that is estimated to affect more than a quarter of the world’s adult population. It is classified on the basis of both its pathophysiology (primary and secondary HT) and on the resting BP values (elevated systolic, diastolic, and pulse pressure). It originates from a complicated interaction of genes and several environmental risk factors including aging, smoking, lack of exercise, overweight and obesity, elevated salt intake, stress, depression, and anxiety. Anxiety and depressive disorders are the most commonly diagnosed mental disorders, affecting millions of people each year and impairing every aspect of everyday life, both of them characterized by affective, cognitive, psychomotor, and neurovegetative symptoms. Moreover, work-related stress has been considered as an important risk factor for HT and cardiovascular diseases (CVDs). Although different authors have investigated and suggested possible relations between HT, stress, anxiety, and depression during the last decades, a full understanding of the underlying pathophysiological mechanisms has not been satisfactorily achieved, especially in young adults. The aim of this study was to investigate the impact of anxiety and work-related stress in the development of HT amongst young health care profession students and the possible related consequences of early CVDs.

show abstract

Section: Discussionmentioning

confidence: 99%

Anxiety, Stress-Related Factors, and Blood Pressure in Young Adults

et al. 2016

View full text Add to dashboard Cite

show abstract

“…[1015–17] The β receptors mediate activation of hormone sensitive lipase in fat cells, leading to release of free fatty acids into the circulation. Beta receptor antagonists modify the metabolism of carbohydrates and lipids by attenuating the release of free fatty acids from adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

Comparison of nebivolol and atenolol on blood pressure, blood sugar, and lipid profile in patients of essential hypertension

et al. 2011

View full text Add to dashboard Cite

Background:Nebivolol is a third-generation β-blocker, with highest β1 selectivity and nitric-oxide-derived vasodilatation. It also exhibits antiproliferative and antioxidant property that has beneficial metabolic profile compared to second-generation β blockers like atenolol. This study was planned to study the comparative effects of nebivolol and atenolol on metabolic parameters in patients with essential hypertension.Materials and Methods:A prospective, randomized, parallel, open-label clinical study was carried out on patients with essential hypertension. The patients were randomly assigned to receive tablet atenolol (Group A) and nebivolol (Group B) for a period of 24 weeks. Investigations were carried out at baseline and at the end of study period, that is, 24 weeks. Out of 69 patients, 60 completed the study and the data was analyzed using student's t-test. P < 0.05 was considered statistically significant.Results:Atenolol and nebivolol both showed significant (P < 0.001) antihypertensive action after 24 weeks. Mean blood sugar and lipid profile were found to be significantly (P < 0.001) elevated after 24 weeks of treatment with atenolol but not with nebivolol. Heart rate was significantly (P < 0.001) decreased in both groups at 24 weeks.Conclusion:In view of metabolic adverse effects of atenolol, nebivolol is the better choice whenever β-blockers have to be used in essential hypertension.

show abstract

“…It is well known that $-blockers blunt HR responses and blood pressures to exercise, but not oxygen consumption. 45,46 Although 6 participants were using $-blockers, they were evenly distributed to the intervention and control groups, and the overall number was limited. Thus, this would not have affected the group differences and any significant differences in the findings of this study.…”

Section: N Limitations and Strengthsmentioning

confidence: 99%

Cardiopulmonary Responses and Adherence to Exercise in Women Newly Diagnosed With Breast Cancer Undergoing Adjuvant Therapy

et al. 2006

View full text Add to dashboard Cite

Adherence to exercise Adjuvant therapy Breast cancer Cardiopulmonary responsesCardiopulmonary responses to an 8-week moderate-intensity aerobic exercise intervention and adherence to exercise during and after intervention were assessed in 41 women newly diagnosed with breast cancer undergoing adjuvant therapy. The intervention was primarily aimed at minimizing deconditioning. Women were randomly assigned to the intervention or control group, completed graded exercise tests before and after intervention, and encouraged to continue their exercise postintervention. Over time, only the intervention group showed significant decreases in resting heart rate, resting systolic blood pressure (SBP), P G .05 each, and maximum SBP, P G .02, and an increase in VO 2 peak, P G .001, although resting SBP was higher in the intervention group at both timepoints, P G .05. The adherence rate to 8-week exercise intervention was 78.3% with average weekly attendance of 2.4 sessions and 42.7 minutes (27.8 minutes within target heart rate) exercise per session. Overall physical activity levels over 16 weeks postintervention did not differ between 2 groups. However, the within-group analysis indicated that only the intervention group showed a significant increase in voluntary activity, P G .02, and energy expenditure, P G .02, and a decrease in sedentary activity, P G .02. These findings indicate that moderate-intensity aerobic exercise is beneficial in reducing deconditioning of cardiopulmonary responses in newly diagnosed breast cancer women undergoing adjuvant therapy.156 n Cancer Nursing TM

show abstract

Integrated effects of the vasodilating beta-blocker nebivolol on exercise performance, energy metabolism, cardiovascular and neurohormonal parameters in physically active patients with arterial hypertension

Cited by 34 publications

References 35 publications

Anxiety, Stress-Related Factors, and Blood Pressure in Young Adults

Anxiety, Stress-Related Factors, and Blood Pressure in Young Adults

Comparison of nebivolol and atenolol on blood pressure, blood sugar, and lipid profile in patients of essential hypertension

Cardiopulmonary Responses and Adherence to Exercise in Women Newly Diagnosed With Breast Cancer Undergoing Adjuvant Therapy

Contact Info

Product

Resources

About