Influence of the LH-RH analogue buserelin on cyclic ovarian function and on endometrium. A new approach to fertility control?

GnRH agonist for postpartum contraception: Biochemical, hormonal and endometrial effects

“…A marked reduction of estrogen secretion resulted in hypoestrogen symptoms; a lesser degree of suppression caused fluctuating blood estrogen concentrations that stimulated the endometrium. After the constant use of the compound, endometrial hyperplasia has been reported [8,9]. Regarding estradiol levels, women taking buserelin showed different grades of follicular activity; however, no case of endometrial hyperplasia was found in the histopathologic studies.…”

“…Continued suppression of estrogen may induce changes in bone metabolism and lipid and biochemical profiles (clinical chemistry). Unopposed estrogen induces endometrial growth with resulting bleeding at regular or irregular intervals, and endometrial hyperplasia has been reported [8,9].…”

Antifertility effects of GnRH

“…In these studies individual variations were observed in the concentrations of oestradiol-17ß in the blood. For (Bergquist et al, 1979b;Schmidt-Gollwitzer et al, 1981 ;Text-fig. 5).…”

Luteinizing hormone releasing hormone agonist for postpartum contraception

“…Therefore, there is a great need for a reliable, acceptable, safe and easily-administered method for contraception for breastfeeding women. A GnRH agonist such as buserelin presents the advantage that, being a peptide, it is without the metabolic effects observed with the synthetic steroids [4,5]. When it is administered daily by nasal spray for long periods of time, it can successfully prevent ovulation [6][7][8][9][10].…”