BackgroundThe compliance rate with supportive therapy following peri‐implantitis treatment (SPIT) remains unknown. The present retrospective study was carried out to assess the compliance rate and the factors influencing compliance in a private practice setting.Materials and MethodsPatients were divided into three groups according to compliance rate: regular compliance (RC ≥2 SPIT/year), erratic compliance (EC <2 SPIT/year), and non‐compliance (NC <1 SPIT/year). Overall, 17 patient‐ (n = 8) and site‐related variables (n = 9) were explored as potential confounders of compliance. The Chi2 test was applied to assess the association between categorical variables and determine the odds ratio (OR).ResultsThe study comprised 159 patients restored with 1075 implants, of which 469 were treated for peri‐implantitis and met the inclusion criteria. A total of 57.2% were RC, 25.8% EC, and 17% NC. The multivariate analysis showed that smoking and grade C periodontitis reduced the likelihood of RC (OR = 0.28, p < .001) when compared to complete edentulism or non‐smoking. Moreover, age demonstrated being associated with follow‐up when SPIT was interrupted in EC and NC (OR = 0.94, p = .007).ConclusionComprehensive information, provided prior to peri‐implantitis treatment, regarding the importance of adhering to SPIT after peri‐implantitis treatment to achieve/maintain peri‐implant health, resulted in ~60% regular compliance rate (NCT05772078).