“…~ i m u n e k et al. 1980ab;1982;1983;1985 abc;Sid d i que et al 1979ab and ~ i m u n e k and Jar 0 S 1985) and other investigations along this line are in progress. In these studies it was found that sulphamethazine increased acute toxicity of phenobarbital in chickens with advancing age, that under the conditions used in our experiments nitrovin, carbadox, o~dox and cyadox affected the kinetics of injected sulphamethazine, which became manifested by a small rise of its blood levels and a more rapid decline of these levels particularly in younger age groups of domestic fowls and pigs, whereas its blood levels in cyadox-medicated chickens given this sulphonamide per os were lower, that sodium nitrite increased the intensity of suppressive action of phenobarbital on the eNS in chickens in dependence upon age and that administration of sulphamethazine enhanced the intensity of this suppressive action even further, and that ascorbic acid had only little positive effect on sulphamethazine blood levels of domestic fowls.…”