Influence of the degradation of the organic matrix on the microscopic fracture behavior of trabecular bone

Fantner, Georg E.; Birkedal, Henrik; Kindt, Johannes H.; Hassenkam, Tue; Weaver, James C.; Cutroni, Jacquelin A.; Bosma, Bonnie; Bawazer, Lukmaan A.; Finch, Marquesa M.; Cidade, Geraldo A. G.; Morse, Daniel E.; Stucky, Galen D.; Hansma, Paul K.

doi:10.1016/j.bone.2004.05.027

Cited by 114 publications

(59 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Bone heated under these conditions had previously been shown to have reduced resistance to fracture. 32,33 Here, we report that this relationship, greater IDI for bone with degraded mechanical properties, is also seen in another model system: irradiated versus control bovine femur.…”

Section: A Irradiated Versus Control Bovine Femoral Bonesupporting

confidence: 55%

The bone diagnostic instrument II: Indentation distance increase

Hansma¹,

Turner²,

Drake³

et al. 2008

Review of Scientific Instruments

View full text Add to dashboard Cite

The bone diagnostic instrument ͑BDI͒ is being developed with the long-term goal of providing a way for researchers and clinicians to measure bone material properties of human bone in vivo. Such measurements could contribute to the overall assessment of bone fragility in the future. Here, we describe an improved BDI, the Osteoprobe II™. In the Osteoprobe II™, the probe assembly, which is designed to penetrate soft tissue, consists of a reference probe ͑a 22 gauge hypodermic needle͒ and a test probe ͑a small diameter, sharpened rod͒ which slides through the inside of the reference probe. The probe assembly is inserted through the skin to rest on the bone. The distance that the test probe is indented into the bone can be measured relative to the position of the reference probe. At this stage of development, the indentation distance increase ͑IDI͒ with repeated cycling to a fixed force appears to best distinguish bone that is more easily fractured from bone that is less easily fractured. Specifically, in three model systems, in which previous mechanical testing and/or tests reported here found degraded mechanical properties such as toughness and postyield strain, the BDI found increased IDI. However, it must be emphasized that, at this time, neither the IDI nor any other mechanical measurement by any technique has been shown clinically to correlate with fracture risk. Further, we do not yet understand the mechanism responsible for determining IDI beyond noting that it is a measure of the continuing damage that results from repeated loading. As such, it is more a measure of plasticity than elasticity in the bone.

show abstract

Section: A Irradiated Versus Control Bovine Femoral Bonesupporting

confidence: 55%

The bone diagnostic instrument II: Indentation distance increase

Hansma¹,

Turner²,

Drake³

et al. 2008

Review of Scientific Instruments

View full text Add to dashboard Cite

show abstract

“…The composition and structure of collagen components have long been recognized as important contributors to bone quality [31][32][33]. The importance of collagen components in bone mechanical properties has been demonstrated through irreversible collagen manipulations, such as formalin fixation [34], heat denaturation [35,36], and X-ray irradiation [37,38]. Studies demonstrate that collagen manipulations affect bone mechanical properties; collagen contributes predominantly to bone toughness, whereas mineral contents contribute to stiffness and strength [39][40][41].…”

Section: Collagen In Bonementioning

confidence: 99%

A paradigm shift for bone quality in dentistry: A literature review

Kuroshima

Kaku

Ishimoto

et al. 2017

Journal of Prosthodontic Research

View full text Add to dashboard Cite

A B S T R A C TPurpose: The aim of this study was to present the current concept of bone quality based on the proposal by the National Institutes of Health (NIH) and some of the cellular and molecular factors that affect bone quality. Study selection: This is a literature review which focuses on collagen, biological apatite (BAp), and bone cells such as osteoblasts and osteocytes. Results: In dentistry, the term "bone quality" has long been considered to be synonymous with bone mineral density (BMD) based on radiographic and sensible evaluations. In 2000, the NIH proposed the concept of bone quality as "the sum of all characteristics of bone that influence the bone's resistance to fracture," which is completely independent of BMD. The NIH defines bone quality as comprising bone architecture, bone turnover, bone mineralization, and micro-damage accumulation. Moreover, our investigations have demonstrated that BAp, collagen, and bone cells such as osteoblasts and osteocytes play essential roles in controlling the current concept of bone quality in bone around hip and dental implants. Conclusion: The current concept of bone quality is crucial for understanding bone mechanical functions. BAp, collagen and osteocytes are the main factors affecting bone quality. Moreover, mechanical loading dynamically adapts bone quality. Understanding the current concept of bone quality is required in dentistry.

show abstract

“…Clearly, non-linear behavior of the trabecular framework can also be related to the heterogeneity of the extracellular matrix (Fantner et al, 2004;Gao, 2006;Viguet-Carrin et al, 2006). Microdamage could accumulate and lead to structure failure.…”

Section: Discussionmentioning

confidence: 99%

Trabecular Fracture Zone Might Not Be the Higher Strain Region of the Trabecular Framework

et al. 2018

View full text Add to dashboard Cite

Trabecular bone fracture is a traumatic and localized event studied worldwide in order to predict it. During the years, researchers focused over the mechanical characterization of the trabecular tissue to understand its mechanics. Several studies pointed out the very local nature of the trabecular failure, finally identifying the fracture zone with the aim to study it separately. The complexity of the three-dimensional trabecular framework and the local nature of the fracture event do not allow the direct evaluation of a single trabecula's behavior within its natural environment. For this reason, micro-Finite Element Modeling has been seen as the best way to investigate this biomechanical issue. Mechanical strain analysis is adopted in the literature for the identification of micro fracture using criteria based on principal strains. However, it was never verified if the fracture zone is actually the zone where principal strains are concentrated. Here, we show how the maximum strain of the tissue might not be directly correlated to the fracture. In the present work, a previously validated technique was used to identify the fracture zone of 10 trabecular specimen mechanically tested in compression and scanned in micro-CT before and after the mechanical test. Before-compression datasets were used to develop 10 micro-FE models were the same boundary conditions of the mechanical test were reproduced. Our results show how the known linear behavior of the trabecular framework might not be directly related to the development of the fracture suggesting other non-linear phenomenon, like buckling or microdamage, as actual cause of the traumatic event. This result might have several implications both in micro-modeling and in clinical applications for the study of fracture related pathology, like osteoporosis.

show abstract

Influence of the degradation of the organic matrix on the microscopic fracture behavior of trabecular bone

Cited by 114 publications

References 45 publications

The bone diagnostic instrument II: Indentation distance increase

The bone diagnostic instrument II: Indentation distance increase

A paradigm shift for bone quality in dentistry: A literature review

Trabecular Fracture Zone Might Not Be the Higher Strain Region of the Trabecular Framework

Contact Info

Product

Resources

About